tetano
Editor, Senior Moderator
Mol Biol Rep
. 2024 Jan 22;51(1):180.
doi: 10.1007/s11033-023-09189-4. ACE I/D polymorphism is a risk factor for the clinical severity of COVID-19 in Brazilian male patients
Sandro Soares Almeida[SUP] 1 2 3 [/SUP], Marcos Fernandes Gregnani[SUP] 4 [/SUP], Isabela Moreira Gontijo da Costa[SUP] 5 [/SUP], Matheus Matias da Silva[SUP] 5 [/SUP], Carolina Bonet Bub[SUP] 5 [/SUP], Valmir Oliveira Silvino[SUP] 6 7 [/SUP], Delio Eulalio Martins[SUP] 5 [/SUP], Marcelo Wajchenberg[SUP] 5 [/SUP]
Affiliations
Background: The renin-angiotensin system is potentially involved in the pathogen-host interaction in the disease caused by SARS-CoV-2, since the angiotensin-converting enzyme (ACE) 2 serves as a receptor for the virus. The impact of the pandemic in specific regions and ethnic groups highlights the importance of investigating genetic factors that disrupt the balance of the system in response to SARS-CoV-2 infection, especially in genes with ethnic frequency variations. Therefore, this study aimed to evaluate the influence of the ACE I/D polymorphism on the incidence and severity of COVID-19 in a sample of the Brazilian population.
Methods and results: 70 severe cases and 355 mild cases patients were evaluated. DNA extraction was performed using a QIAamp DNA Blood Mini kit. Genotyping of ACE I/D polymorphism was performed. Clinical outcomes were obtained from the patients' records. We found an association between the ACE I/D polymorphism and the incidence or severity of COVID-19 in male participants. Moreover, we observed a relationship between severity and increasing age and body weight and a higher frequency of II genotype individuals among those who had a cough as their symptoms in mild patients. No differences were observed in leukocyte count or other parameters related to the inflammatory response in severe patients.
Conclusions: Our data showed the influence of the ACE I/D polymorphism on severity of COVID-19 in males, as well as on the occurrence of cough in patients with mild symptoms, with a higher incidence in those carrying the I allele.
Keywords: Angiotensin-converting enzyme; Coronavirus; Inflammatory response; SARS-CoV-2.
. 2024 Jan 22;51(1):180.
doi: 10.1007/s11033-023-09189-4. ACE I/D polymorphism is a risk factor for the clinical severity of COVID-19 in Brazilian male patients
Sandro Soares Almeida[SUP] 1 2 3 [/SUP], Marcos Fernandes Gregnani[SUP] 4 [/SUP], Isabela Moreira Gontijo da Costa[SUP] 5 [/SUP], Matheus Matias da Silva[SUP] 5 [/SUP], Carolina Bonet Bub[SUP] 5 [/SUP], Valmir Oliveira Silvino[SUP] 6 7 [/SUP], Delio Eulalio Martins[SUP] 5 [/SUP], Marcelo Wajchenberg[SUP] 5 [/SUP]
Affiliations
- PMID: 38252233
- DOI: 10.1007/s11033-023-09189-4
Background: The renin-angiotensin system is potentially involved in the pathogen-host interaction in the disease caused by SARS-CoV-2, since the angiotensin-converting enzyme (ACE) 2 serves as a receptor for the virus. The impact of the pandemic in specific regions and ethnic groups highlights the importance of investigating genetic factors that disrupt the balance of the system in response to SARS-CoV-2 infection, especially in genes with ethnic frequency variations. Therefore, this study aimed to evaluate the influence of the ACE I/D polymorphism on the incidence and severity of COVID-19 in a sample of the Brazilian population.
Methods and results: 70 severe cases and 355 mild cases patients were evaluated. DNA extraction was performed using a QIAamp DNA Blood Mini kit. Genotyping of ACE I/D polymorphism was performed. Clinical outcomes were obtained from the patients' records. We found an association between the ACE I/D polymorphism and the incidence or severity of COVID-19 in male participants. Moreover, we observed a relationship between severity and increasing age and body weight and a higher frequency of II genotype individuals among those who had a cough as their symptoms in mild patients. No differences were observed in leukocyte count or other parameters related to the inflammatory response in severe patients.
Conclusions: Our data showed the influence of the ACE I/D polymorphism on severity of COVID-19 in males, as well as on the occurrence of cough in patients with mild symptoms, with a higher incidence in those carrying the I allele.
Keywords: Angiotensin-converting enzyme; Coronavirus; Inflammatory response; SARS-CoV-2.