tetano
Editor, Senior Moderator
Mol Biol
. 2022;56(1):29-45.
doi: 10.1134/S0026893322010034. Epub 2022 Feb 12.
MicroRNAs as the Potential Regulators of SARS-CoV-2 Infection and Modifiers of the COVID-19 Clinical Features
A N Kucher[SUP] 1 [/SUP], Iu A Koroleva[SUP] 1 [/SUP], A A Zarubin[SUP] 1 [/SUP], M S Nazarenko[SUP] 1 [/SUP]
Affiliations
Abstract
The pandemic of coronavirus disease 2019 (COVID-19) warrants the identification of factors that may determine both risk and severity of infection. The factors include microRNAs that have a wide regulatory potential and hence are particularly interesting. The review focuses on the potential roles of human microRNAs and the viral genome as well as microRNAs in SARS-CoV-2 infection and clinical features of COVID-19. The review summarizes the information about the human microRNAs that are thought to specifically bind to the SARS-CoV-2 genome and considers their expression levels in various organs (cells) in both healthy state and pathologies that are risk factors for severe COVID-19. Potential mechanisms whereby SARS-CoV-2 may affect the clinical features of COVID-19 are discussed in brief. The mechanisms include blocking of human microRNAs and RNA-binding proteins, changes in gene expression in infected cells, and possible epigenetic modifications of the human genome with the participation of coronavirus microRNAs.
Supplementary information: The online version contains supplementary material available at 10.1134/S0026893322010034.
Keywords: COVID-19; SARS-CoV-2; microRNA.
. 2022;56(1):29-45.
doi: 10.1134/S0026893322010034. Epub 2022 Feb 12.
MicroRNAs as the Potential Regulators of SARS-CoV-2 Infection and Modifiers of the COVID-19 Clinical Features
A N Kucher[SUP] 1 [/SUP], Iu A Koroleva[SUP] 1 [/SUP], A A Zarubin[SUP] 1 [/SUP], M S Nazarenko[SUP] 1 [/SUP]
Affiliations
- PMID: 35464324
- PMCID: PMC9016216
- DOI: 10.1134/S0026893322010034
Abstract
The pandemic of coronavirus disease 2019 (COVID-19) warrants the identification of factors that may determine both risk and severity of infection. The factors include microRNAs that have a wide regulatory potential and hence are particularly interesting. The review focuses on the potential roles of human microRNAs and the viral genome as well as microRNAs in SARS-CoV-2 infection and clinical features of COVID-19. The review summarizes the information about the human microRNAs that are thought to specifically bind to the SARS-CoV-2 genome and considers their expression levels in various organs (cells) in both healthy state and pathologies that are risk factors for severe COVID-19. Potential mechanisms whereby SARS-CoV-2 may affect the clinical features of COVID-19 are discussed in brief. The mechanisms include blocking of human microRNAs and RNA-binding proteins, changes in gene expression in infected cells, and possible epigenetic modifications of the human genome with the participation of coronavirus microRNAs.
Supplementary information: The online version contains supplementary material available at 10.1134/S0026893322010034.
Keywords: COVID-19; SARS-CoV-2; microRNA.