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MIT study of pig and bird influenza viruses that could pose risk to humans

Shiloh

Editor, Senior Moderator
Source: http://www.sciencedaily.com/releases/2013/05/130510180250.htm

Potential Flu Pandemic Lurks

May 10, 2013 ? An MIT study has identified influenza viruses circulating in pigs and birds that could pose a risk to humans.

In the summer of 1968, a new strain of influenza appeared in Hong Kong. This strain, known as H3N2, spread around the globe and eventually killed an estimated 1 million people.

A new study from MIT reveals that there are many strains of H3N2 circulating in birds and pigs that are genetically similar to the 1968 strain and have the potential to generate a pandemic if they leap to humans. The researchers, led by Ram Sasisekharan, the Alfred H. Caspary Professor of Biological Engineering at MIT, also found that current flu vaccines might not offer protection against these strains.

"There are indeed examples of H3N2 that we need to be concerned about," says Sasisekharan, who is also a member of MIT's Koch Institute for Integrative Cancer Research. "From a pandemic-preparedness point of view, we should potentially start including some of these H3 strains as part of influenza vaccines."

The study, which appears in the May 10 issue of the journal Scientific Reports, also offers the World Health Organization and public-health agencies' insight into viral strains that should raise red flags if detected...

...Journal Reference:

Kannan Tharakaraman, Rahul Raman, Nathan W. Stebbins, Karthik Viswanathan, Viswanathan Sasisekharan, Ram Sasisekharan. Antigenically intact hemagglutinin in circulating avian and swine influenza viruses and potential for H3N2 pandemic. Scientific Reports, 2013; 3 DOI: 10.1038/srep01822
 
Re: MIT study of pig and bird influenza viruses that could pose risk to humans

why H3 ? What does H3 have that others don't ?
Shouldn't we worry less about H3, since it's seasonal and we
thus have some immunity ?
------------------------------------------
They might figure it out, what it is that makes these viruses
influenza-pandemic-capable (ipc) and then they might be able to put that
ipc-thing into other serotypes , that we have no immunity to,
by reassortment and recombination ...
That's where it goes, thanks to MIT, isn't it ?

ironically it's not clear from the headline, from the English grammar, whether the viruses
or the study put the risk to humans , although from reading the article I think they
meant the viruses. They wanted the readers think it were the viruses.
 
Re: MIT study of pig and bird influenza viruses that could pose risk to humans

full paper available here: (9 pages, pdf)
http://www.nature.com/srep/2013/130510/srep01822/full/srep01822.html
H3-like glycosylation pattern
Among the 1103 avian and swine H3 HA sequences, 359 carried additional glycosylation
sites or positional shifts and therefore were removed from further consideration.
The remaining 744 HA sequences (, 67%) were found to possess the 1968 pandemic
HA-like glycosylation pattern.
harbor seals
A/Minnesota/11/2010



Sasisekharan:

19 December 2011
Networks link antigenic and receptor-binding sites of influenza hemagglutinin: Mechanistic
insight into fitter strain propagation
open Venkataramanan Soundararajan, Shu Zheng, Neel Patel, Ken Warnock, Rahul Raman,
Ian A. Wilson, S. Raguram, V. Sasisekharan & Ram Sasisekharan + et al.
Scientific Reports 1, doi:10.1038/srep00200

10 May 2013
Antigenically intact hemagglutinin in circulating avian and swine influenza viruses and
potential for H3N2 pandemic
open Kannan Tharakaraman, Rahul Raman, Nathan W. Stebbins, Karthik Viswanathan,
Viswanathan Sasisekharan & Ram Sasisekharan + et al.
Scientific Reports 3, doi:10.1038/srep01822

10 December 2012
Expression of a fungal sterol desaturase improves tomato drought tolerance,
pathogen resistance and nutritional quality
open Ayushi Kamthan, Mohan Kamthan, Mohammad Azam, Niranjan Chakraborty,
Subhra Chakraborty & Asis Datta + et al.
Scientific Reports 2, doi:10.1038/srep00951
 
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