tetano
Editor, Senior Moderator
Microorganisms
. 2020 Dec 4;8(12):E1929.
doi: 10.3390/microorganisms8121929.
Eosinopenia in COVID-19 Patients: A Retrospective Analysis
Narcisse Ndieugnou Djangang[SUP] 1 [/SUP], Lorenzo Peluso[SUP] 1 [/SUP], Marta Talamonti[SUP] 1 [/SUP], Antonio Izzi[SUP] 1 [/SUP], Pierre Alain Gevenois[SUP] 2 [/SUP], Alessandra Garufi[SUP] 1 [/SUP], Jean-Christophe Goffard[SUP] 3 [/SUP], Sophie Henrard[SUP] 3 [/SUP], Paolo Severgnini[SUP] 4 [/SUP], Jean-Louis Vincent[SUP] 1 [/SUP], Jacques Creteur[SUP] 1 [/SUP], Fabio Silvio Taccone[SUP] 1 [/SUP]
Affiliations
Abstract
Objectives: The aim of this study was to assess the diagnostic role of eosinophils count in COVID-19 patients. Methods: Retrospective analysis of patients admitted to our hospital with suspicion of COVID-19. Demographic, clinical and laboratory data were collected on admission. Eosinopenia was defined as eosinophils < 100 cells/mm[SUP]3[/SUP]. The outcomes of this study were the association between eosinophils count on admission and positive real-time reverse transcription polymerase chain reaction (rRT-PCR) test and with suggestive chest computerized tomography (CT) of COVID-19 pneumonia. Results: A total of 174 patients was studied. Of those, 54% had positive rRT-PCR for SARS-CoV-2. A chest CT-scan was performed in 145 patients; 71% showed suggestive findings of COVID-19. Eosinophils on admission had a high predictive accuracy for positive rRT-PCR and suggestive chest CT-scan (area under the receiver operating characteristic-ROC curve, 0.84 (95% CIs 0.78-0.90) and 0.84 (95% CIs 0.77-0.91), respectively). Eosinopenia and high LDH were independent predictors of positive rRT-PCR, whereas eosinopenia, high body mass index and hypertension were predictors for suggestive CT-scan findings. Conclusions: Eosinopenia on admission could predict positive rRT-PCR test or suggestive chest CT-scan for COVID-19. This laboratory finding could help to identify patients at high-risk of COVID-19 in the setting where gold standard diagnostic methods are not available.
Keywords: COVID-19; chest CT imaging; coronavirus; eosinophils; reverse transcription polymerase.
. 2020 Dec 4;8(12):E1929.
doi: 10.3390/microorganisms8121929.
Eosinopenia in COVID-19 Patients: A Retrospective Analysis
Narcisse Ndieugnou Djangang[SUP] 1 [/SUP], Lorenzo Peluso[SUP] 1 [/SUP], Marta Talamonti[SUP] 1 [/SUP], Antonio Izzi[SUP] 1 [/SUP], Pierre Alain Gevenois[SUP] 2 [/SUP], Alessandra Garufi[SUP] 1 [/SUP], Jean-Christophe Goffard[SUP] 3 [/SUP], Sophie Henrard[SUP] 3 [/SUP], Paolo Severgnini[SUP] 4 [/SUP], Jean-Louis Vincent[SUP] 1 [/SUP], Jacques Creteur[SUP] 1 [/SUP], Fabio Silvio Taccone[SUP] 1 [/SUP]
Affiliations
- PMID: 33291791
- DOI: 10.3390/microorganisms8121929
Abstract
Objectives: The aim of this study was to assess the diagnostic role of eosinophils count in COVID-19 patients. Methods: Retrospective analysis of patients admitted to our hospital with suspicion of COVID-19. Demographic, clinical and laboratory data were collected on admission. Eosinopenia was defined as eosinophils < 100 cells/mm[SUP]3[/SUP]. The outcomes of this study were the association between eosinophils count on admission and positive real-time reverse transcription polymerase chain reaction (rRT-PCR) test and with suggestive chest computerized tomography (CT) of COVID-19 pneumonia. Results: A total of 174 patients was studied. Of those, 54% had positive rRT-PCR for SARS-CoV-2. A chest CT-scan was performed in 145 patients; 71% showed suggestive findings of COVID-19. Eosinophils on admission had a high predictive accuracy for positive rRT-PCR and suggestive chest CT-scan (area under the receiver operating characteristic-ROC curve, 0.84 (95% CIs 0.78-0.90) and 0.84 (95% CIs 0.77-0.91), respectively). Eosinopenia and high LDH were independent predictors of positive rRT-PCR, whereas eosinopenia, high body mass index and hypertension were predictors for suggestive CT-scan findings. Conclusions: Eosinopenia on admission could predict positive rRT-PCR test or suggestive chest CT-scan for COVID-19. This laboratory finding could help to identify patients at high-risk of COVID-19 in the setting where gold standard diagnostic methods are not available.
Keywords: COVID-19; chest CT imaging; coronavirus; eosinophils; reverse transcription polymerase.