tetano
Editor, Senior Moderator
J Virol. 2011 Sep 14. [Epub ahead of print]
MHC Class II Expression and Hemagglutinin Subtype Influence the Infectivity of Type A Influenza Virus for Respiratory Dendritic Cells.
Hargadon KM, Zhou H, Albrecht RA, Dodd HA, Garc?a-Sastre A, Braciale TJ.
Source
The Carter Immunology Center.
Abstract
Dendritic cells play a key role in antiviral immunity, functioning as both innate effector cells in early phases of the immune response and subsequently as antigen presenting cells that activate the adaptive immune response. In the murine respiratory tract, there are several respiratory dendritic cell (RDC) subsets, including CD103(+) DC, CD11b(hi) DC, monocyte/macrophage DC, and plasmacytoid DC. However, little is known about the interaction between these tissue-resident RDC and viruses that are encountered during natural infection in the respiratory tract. Here, we show both in vitro and in vivo that the susceptibility of murine RDC to infection with type A influenza virus varies with the level of MHC class II expression by RDC and with the virus strain. Both CD103(+) and CD11b(hi) RDC which express the highest basal level of MHC class II are most susceptible to infection by type A influenza virus. However, efficient infection is restricted to type A influenza strains of the H2N2 subtype. Furthermore, enhanced infectivity by viruses of the H2N2 subtype is linked to the expression of the I-E MHC class II locus product. These results suggest a potential novel role for MHC class II molecules in influenza virus infection and pathogenesis in the respiratory tract.
PMID:
21917972
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21917972
MHC Class II Expression and Hemagglutinin Subtype Influence the Infectivity of Type A Influenza Virus for Respiratory Dendritic Cells.
Hargadon KM, Zhou H, Albrecht RA, Dodd HA, Garc?a-Sastre A, Braciale TJ.
Source
The Carter Immunology Center.
Abstract
Dendritic cells play a key role in antiviral immunity, functioning as both innate effector cells in early phases of the immune response and subsequently as antigen presenting cells that activate the adaptive immune response. In the murine respiratory tract, there are several respiratory dendritic cell (RDC) subsets, including CD103(+) DC, CD11b(hi) DC, monocyte/macrophage DC, and plasmacytoid DC. However, little is known about the interaction between these tissue-resident RDC and viruses that are encountered during natural infection in the respiratory tract. Here, we show both in vitro and in vivo that the susceptibility of murine RDC to infection with type A influenza virus varies with the level of MHC class II expression by RDC and with the virus strain. Both CD103(+) and CD11b(hi) RDC which express the highest basal level of MHC class II are most susceptible to infection by type A influenza virus. However, efficient infection is restricted to type A influenza strains of the H2N2 subtype. Furthermore, enhanced infectivity by viruses of the H2N2 subtype is linked to the expression of the I-E MHC class II locus product. These results suggest a potential novel role for MHC class II molecules in influenza virus infection and pathogenesis in the respiratory tract.
PMID:
21917972
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21917972