Mexico detected mutations in influenza A (H1N1)

[Tonka]

http://www.prensa-latina.cu/index.php?option=com_content&task=view&id=167242&Itemid=1

Mexico detected mutation in influenza A (H1N1)
Written by Maria Julia Mayoral
mi?rcoles, 03 of 2010 of marzo

03 of March 2010, 00:49Mexico, Mar 3 (Prensa Latina) The Ministry of Health in Mexico confirmed the detection in the country of a genetic mutation in human influenza virus A (H1N1), which confers resistance to the antiviral oseltamivir (Tamiflu).

The change appeared in the position of H274Y in neuraminidase gene (NA) of influenza virus A (H1N1) and one patient was found in 10 month old baby, who survived the disease, detailing the ministry statement said.

According to the agency, the mother of the little spoke by telephone to the daughter is well, with mild cough and runny nose alone.

Laboratory tests were conducted by the Institute of Epidemiological Diagnosis and Reference by PCR in real time, says the official note.

Originally from the municipality of Ecatepec, State of Mexico, the baby was admitted on January 4 Pediatric Hospital La Villa, for mild respiratory distress syndrome, malnutrition grade one and bronchiolitis, the ministry said.

She was discharged after showing satisfactory progress without complications, but 10 days later he returned to the Hospital Infantil de Mexico "Federico Gomez" diagnosed with severe pneumonia, malnutrition of moderate intensity and influenza-like illness.

He then transferred to Children's Hospital La Villa, where he was discharged on Feb. 3.

The discovery of the mutation, said Health, does not change the treatment policy in the future, it is the only resistant strain found between 420 sequenced.

lac / mjm

 

[Tonka]

Re: Mexico detected mutation in influenza A (H1N1)

Re: Mexico detected mutation in influenza A (H1N1)

http://www.milenio.com/node/393298

Mutation A/H1N1 virus, resistant to Tamiflu
Tests confirm the change so far has been defined "not serious".

Wed, 03/03/2010 - 05:06

The official says the vaccination is going well. Photo: H?ctor T?llez / Archive Mexico.- The Ministry of Health reported the first mutation detected in the influenza A/H1N1 virus in the position of H274Y in neuraminidase gene (NA) in a patient ten months old, who survived the disease but showed resistance to the antiviral oseltamivir (Tamiflu).

The infant "is good, with mild cough and runny nose alone, according to the report he released his mother by telephone on March 1.

The Institute of Epidemiological Diagnosis and Reference (INDRE) conducted laboratory tests using PCR in real time, and confirmed the mutation, so far has been defined not serious.

"This finding does not change the treatment policy in the future, since it is the only strain found resistant of 420 sequenced, which means less resistance to .25%."

The SSA has not reported whether this case could trigger a wave of people infected oseltamivir resistance, and so must use the accumulated reserve in case of zanamivir resistance.

Little is originally from Ecatepec, Mexico state, was admitted on January 4 Pediatric Hospital La Villa, for mild respiratory distress syndrome, malnutrition grade one and bronchiolitis. She was discharged after showing satisfactory progress smoothly.

Joined ten days later to Children's Hospital of Mexico "Federico Gomez", diagnosed with severe pneumonia, moderate malnutrition and influenza-like illness.

After control was achieved, was taken to Children's Hospital in the town to continue treatment, where he was discharged on Feb. 3.

The federal government recognized a serious case of H1N1 mutation, as in Norway and, therefore, began to shape a "small strategic reserve" of over 100 thousand zanamivir treatment in case of detection of patients resistant to Tamiflu .

"If there was a mutation that causes a resistance to Tamiflu, an antiviral drug would be changed for another. Mexico is ready with an alternate booking more than 100 thousand zanamivir treatment is still small, but we would cope. At this point we are not facing that situation, "noted Alejandro Macias, national commissioner for the care of influenza.

In turn, the Director National Institute of Epidemiological Diagnosis and Reference, Celia Alpuche, said the Mexican case of severe mutation corresponds to the second patient treated at INER in April when the pandemic began.

A few months ago, WHO issued an alert and suggested to Norway, Brazil, China, Japan, Ukraine, USA and Mexico, where mutations have been reported, carrying out more detailed summaries and sequencing, in order to determine whether or not more virulent .

Dismissing raise alert

? ? ? The Federal Ministry of Health ruled that in March, as forecast, raise the alert for the H1N1 pandemic contingency because it continues to increase, more mild aunquede, the number of infections: 71 thousand 90 cases, and 88 thousand deaths (nine more than the previous report).
Jose Angel Cordova, Secretary of Health, explained that almost a year after the outbreak of the pandemic by the new virus called H1N1, high transmissibility, but with minor consequences and not so serious for most, the Audit Committee Epidemiological evaluated even if it is time to lift the health contingency.

Meanwhile, the municipal government will continue with the alert to respond to outbreaks of H1N1, so you will expand the vaccination campaign Metrobus stations and some trolleybus, in order to reach more segments of the population. (Mexico ? Blanca Valadez and Miriam Castillo)

Blanca Valadez

 

[Tonka]

Re: Mexico detected mutation in influenza A (H1N1)

Re: Mexico detected mutation in influenza A (H1N1)

http://www.eluniversal.com.mx/notas/663041.html

Ssa 423 suspected cases of A H1N1 mutation

Health Secretary Jose Angel Cordova, notes that since the beginning of the epidemic to date have applied more than one million anti-viral treatments


Ruth Rodriguez
El Universal
MEXICO CITY Wednesday, 03 marzo of 2010
11:02

Jose Angel Cordova Villalobos, Secretary of Health, confirmed the first case of a person in Mexico where the AH1N1 influenza virus mutated and became resistant to antiviral treatment.

The official did not rule out the possibility of more cases in the country.

Against this background, said the virus could mutate at any time and cause serious problems.

Hence, he added, the importance that people be vaccinated to be protected.

He said the case of small 10-month-old, which was confirmed mutation of influenza virus a week ago, is the first of 423 cases of suspected mutation, which scored a low rate.

Cordova Villalobos said that since the beginning of the epidemic to date have been applied over a million of antiviral therapies and has only one instance of resistance, which is the girl who was hospitalized in the town hospital and subsequently readmitted.

He said that to reduce the chances of resistance to oseltamivir, for the past six months has begun to implement in the medical units Zanamivir the second antiviral treatment have to attack the influenza virus.

On the application of vaccines, Cordova said that until last Friday was administered six million 700 thousand vaccines and is expected to conclude this weekend pair with eight million.

In this sense confided that for April and May will have already implemented 20 million vaccines.
He reported that so far there are 90 thousand deaths.

elc / fml

 

[Tonka]

Re: Mexico detected mutation in influenza A (H1N1)

Re: Mexico detected mutation in influenza A (H1N1)

http://www.jornada.unam.mx/2010/03/04/index.php?section=sociedad&article=040n1soc

The mutation of the H1N1 virus, 0.25%: Ssa
?ngeles Cruz Martinez

La Jornada
Thursday, 4 March 2010, p. 40
About 20 cases of mutation of the H1N1 influenza virus resistant to the antiviral oseltamivir, as detected in Mexico, have also been staged in other countries and are likely being reported here, warned the Health Ministry (SSA). Thus the importance of the vaccine, said the head of the agency, Jose Angel Cordova Villalobos.

Undersecretary for Prevention and Health Promotion, Mauricio Hernandez Avila, said that although the resistance of the virus was found only in one patient, one should not underestimate the problem. He said the daughter, aged 10, acquired the flu and was complicated to the degree that she was in intensive care.

For that reason entered the system of epidemiological surveillance for resistance. He took samples of the strain were sent to the laboratory for genetic sequencing. That mutation was detected at position H274Y neuraminidase gene.

Hernandez explained that the Institute of Epidemiological Diagnosis and Reference (Indre) virus genetic studies of cases of patients suffering serious complications and probabilistic methods other strains are selected for analysis.

Cordova said that of the 423 samples suspected to contain a mutation, information obtained from the girl is the first in which is located to the antiviral resistance, equivalent to 0.25 percent.
The secretary also stressed the importance of continuing the implementation of the A/H1N1 virus vaccine, which until last Friday had given 6 million 700 thousand doses. He stressed that the biological virus protection even if it is resistant to drugs.

The SSA estimates that between April and May next will have implemented 20million doses. The strategy will continue throughout the year and some antigens are reserved for pregnant women.

On Tuesday, the agency reported the first case of resistance of influenza, a girl who was admitted on January 4 Pediatric Hospital La Villa, for mild respiratory distress syndrome, malnutrition grade I and bronchiolitis. She was discharged after showing satisfactory progress smoothly.

At 10 days, was admitted to Hospital Infantil de Mexico Federico Gomez diagnosed with severe pneumonia, malnutrition of moderate intensity and influenza-like illness. Once the evil was controlled, moved to La Villa Pedri?rtico to continue his treatment, where he was discharged on Feb. 3.

 

[tropical]

Re: Mexico detected mutations in influenza A (H1N1)

#2:"71 thousand 90 cases, and 88 thousand deaths (nine more than the previous report)"


88000 Mehico deaths, could it be realy?

maybe 1 thousand 88 cases:

from the #2 given linked news:
"71 mil 90 casos y mil 88 fallecimientos"

 

[Tonka]

Re: Mexico detected mutations in influenza A (H1N1)

Tropical, 1,088 deaths..sorry if i'm mis-understanding your question.

Numeralia/Influenza A H1N1

Entidad / Fuente Casos confirmados Defunciones
Mundo OMS N/D 16,226
M?xico / SSA 71,090 1,088
Jalisco / SSJ 4,258* 90
Fecha defunciones OMS: 14/02/2010 Corte M?xico: 01/03/2010

http://informacioninfluenza.jalisco.gob.mx/

 

[tropical]

Re: Mexico detected mutations in influenza A (H1N1)

Hi Tonka,
thanks for the answer and for your news good contributions.

Hopefully, the 3rd wave will estinguish itself.

 

[alert]

Re: Mexico detected mutations in influenza A (H1N1)

Yes, "mil 88" is 1,088, not 88,000. Google translator does that.

Remember, the line in the original discovery thread about 500,000 cases when they meant 1,500 cases? Google has a bug in the translator, I suspect.

 

[Tonka]

Re: Mexico detected mutations in influenza A (H1N1)

http://www.milenio.com/node/396266

Health more mutations discarded as A H1N1
Undersecretary of Health, Gabriel O 'Shea Cuevas said the need for annual vaccine is changed seasonally.

Sun, 07/03/2010 - 13:22

Continue with prevention. Photo: Magali Lopez

Following the case of mutation of the H1N1 virus in a baby of 10 months of this municipality, Undersecretary of Health in the state, Gabriel O 'Shea Cuevas pointed the need for annual vaccine is changed seasonally.

He explained that some mutations make it resistant to drugs such as this little one in Mexico, 21 in the U.S. and 50 in Europe.

"Apparently there are about 250 patients worldwide who have resistance to the antiviral oseltamivir, but very good response with zanamivir, which is the second option, and we have a guard of 10 thousand doses for these cases, so that people should not worry.

The state official clarified that the mutated virus does not mean it to be more aggressive just means there is resistance to medications.

"The best measure to combat it is to vaccinate as immunity levels achieved are very high and acceptable."

Cuevas O'Shea spoke "the percentage of mutated virus resistance is 0.25 percent, almost anything, but we are in complete epidemiological surveillance to confirm the existence of similar cases.

He recalled that the sample of girls of 10 months was analyzed by the National Institute of Epidemiological Diagnosis and Reference (INDRE) together with other 420 who had negative results of mutation.
He said providing for the application of one million 400 thousand shots in the State of Mexico at the end of the National Vaccination Week, which would correspond to 74 percent of the doses received in the entity.

He said the case of the girl discharged last month, shows that the mutation of the virus is minimal, "since the disease was controlled and is alive.

"Initially the baby was treated in the pediatric Villa, where he had been diagnosed I had bronchitis, a few days was discharged with antibiotic treatment, but returned after 10 days with a picture of pneumonia was severe and when the interned at Children's Hospital, where fortunately left stable. "

Ecatepec / Sandra Marina