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Method for screening for new or unexpected food contaminants has been developed

Emily

Emily

Editor, Senior Moderator
http://link.springer.com/article/10.1007/s00216-012-6506-5/fulltext.html
Analytical and Bioanalytical Chemistry? The Author(s) 201210.1007/s00216-012-6506-5
Original Paper
A concept study on non-targeted screening for chemical contaminants in food using liquid chromatography?mass spectrometry in combination with a metabolomics approach
Erik Tengstrand1, Johan Ros?n2, Karl-Erik Hellen?s2 and K. Magnus ?berg1
(1)
Department of Analytical Chemistry, Stockholm University, 10691 Stockholm, Sweden
(2)
National Food Administration, Box 622, 75126 Uppsala, Sweden

K. Magnus ?berg

Received: 17 August 2012
Revised: 13 October 2012Accepted: 17 October 2012
Published online: 1 November 2012
Abstract
A generic method to screen for new or unexpected contaminants at ppm levels in food has been developed. The method comprises an acidic acetonitrile extraction, detection with ultra-high-pressure liquid chromatography coupled to electrospray ionisation time-of-flight mass spectrometry and statistical evaluation using a metabolomics approach comparing suspected contaminated food with uncontaminated foods. The method was tested for 26 model contaminants from 100 μg/g down to 0.4 μg/g in three brands of fresh orange juice. Blinded statistical evaluation revealed signals from all added contaminants detectable by liquid chromatography?electrospray ionisation using positive ionisation mode, while only two false-positive signals were reported. The method is primarily intended to be used for investigation of food samples suspected to be contaminated with unknown substances. Additionally it could be used to continuously monitor for appearance of new food contaminants as a complement to the specific targeted analysis that is today?s foundation of food safety analysis.
Keywords
Chemometrics/statistics Foods/beverages HPLC Mass spectrometry/ICP-MS


Open Access
This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
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Full text at link. :tiphat:
 
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