tetano
Editor, Senior Moderator
Arch Immunol Ther Exp (Warsz). 2013 May 25. [Epub ahead of print]
Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful.
Kai McKinstry K, Dutton RW, Swain SL, Strutt TM.
Source
Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01583, USA, kai.mckinstry@umassmed.edu.
Abstract
Recent observations have uncovered multiple pathways whereby CD4 T cells can contribute to protective immune responses against microbial threats. Incorporating the generation of memory CD4 T cells into vaccine strategies thus presents an attractive approach toward improving immunity against several important human pathogens, especially those against which antibody responses alone are inadequate to confer long-term immunity. Here, we review how memory CD4 T cells provide protection against influenza viruses. We discuss the complexities of protective memory CD4 T cell responses observed in animal models and the potential challenges of translating these observations into the clinic. Specifically, we concentrate on how better understanding of organ-specific heterogeneity of responding cells and defining multiple correlates of protection might improve vaccine-generated memory CD4 T cells to better protect against seasonal, and more importantly, pandemic influenza.
PMID:
23708562
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23708562
Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful.
Kai McKinstry K, Dutton RW, Swain SL, Strutt TM.
Source
Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01583, USA, kai.mckinstry@umassmed.edu.
Abstract
Recent observations have uncovered multiple pathways whereby CD4 T cells can contribute to protective immune responses against microbial threats. Incorporating the generation of memory CD4 T cells into vaccine strategies thus presents an attractive approach toward improving immunity against several important human pathogens, especially those against which antibody responses alone are inadequate to confer long-term immunity. Here, we review how memory CD4 T cells provide protection against influenza viruses. We discuss the complexities of protective memory CD4 T cell responses observed in animal models and the potential challenges of translating these observations into the clinic. Specifically, we concentrate on how better understanding of organ-specific heterogeneity of responding cells and defining multiple correlates of protection might improve vaccine-generated memory CD4 T cells to better protect against seasonal, and more importantly, pandemic influenza.
PMID:
23708562
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23708562