tetano
Editor, Senior Moderator
Biomed Res Int. 2014;2014:872370. Epub 2014 Nov 11.
Mechanisms of Action and Efficacy of Statins against Influenza.
Mehrbod P1, Omar AR1, Hair-Bejo M1, Haghani A2, Ideris A1.
Author information
Abstract
The influenza virus (IV) is known to be a resistant virus with frequent mutations, causing severe respiratory diseases in the upper respiratory system. Public health concerns about clinical efficacy of all conventional drugs are ambiguous; therefore, finding additional therapeutic agents is critical to prevent and control influenza outbreaks. Influenza is associated with the induction of proinflammatory cytokines. Scientists have reported that anti-inflammatory drugs, with pleiotropic effects, reduce the burden of severe influenza diseases. Therefore, statins, which are cardioprotective drugs with anti-inflammatory and immunomodulatory effects, may help patients suffering from influenza virus (IV). This review delineates the potential use of statins as an alternative therapy in treating influenza related illness.
PMID:
25478576
[PubMed - as supplied by publisher]
PMCID:
PMC4244940
Free PMC Article
http://www.ncbi.nlm.nih.gov/pubmed/25478576
Mechanisms of Action and Efficacy of Statins against Influenza.
Mehrbod P1, Omar AR1, Hair-Bejo M1, Haghani A2, Ideris A1.
Author information
Abstract
The influenza virus (IV) is known to be a resistant virus with frequent mutations, causing severe respiratory diseases in the upper respiratory system. Public health concerns about clinical efficacy of all conventional drugs are ambiguous; therefore, finding additional therapeutic agents is critical to prevent and control influenza outbreaks. Influenza is associated with the induction of proinflammatory cytokines. Scientists have reported that anti-inflammatory drugs, with pleiotropic effects, reduce the burden of severe influenza diseases. Therefore, statins, which are cardioprotective drugs with anti-inflammatory and immunomodulatory effects, may help patients suffering from influenza virus (IV). This review delineates the potential use of statins as an alternative therapy in treating influenza related illness.
PMID:
25478576
[PubMed - as supplied by publisher]
PMCID:
PMC4244940
Free PMC Article
http://www.ncbi.nlm.nih.gov/pubmed/25478576