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MEASLES - JAPAN (TOKYO, SAITAMA): ALERT,pro med

Treyfish

Moderator
A measles epidemic is gradually spreading in Tokyo and Saitama
Prefectures, government researchers said.


Researchers at the National Institute of Infectious Diseases (NIID)
said the measles is highly contagious and that the number of patients
could surpass the 280 000 recorded in 2001.

The institute is warning of an epidemic, fearing that holidaymakers
may spread the disease across the country by traveling in various
areas during the Golden Week holiday period from late April to early
May [2007].


After about a 10-day latency period following infection, [patients
develop symptoms that include] high fever, coughing, and a runny nose
for the 1st few days, and then a red rash spreads over their bodies.
Roughly 40 percent of patients need to be hospitalized even though
the death rate from measles is only 0.1 to 0.2 percent.

At least one class has been closed because of the measles epidemic at
an elementary school, a junior high school, and 2 high schools in
Tokyo. One of the high schools, situated in Nerima-ku, was forced to
postpone the beginning of the 1st term of the new school year from [6
Apr 2007] to [10 Apr 2007] because 29 students had suffered from the
measles since early March [2007].

The pediatric departments of about 3000 hospitals across the country
reported 32 cases of the measles over the 2-8 Apr 2007 period alone,
according to the institute.

The number of reported cases of measles began to increase in February
[2007] and the number of adult patients whose condition tends to be
serious has been sharply increasing since mid-March [2007], according
to researchers.
(Mainichi)

--
Communicated by:
ProMED-mail <promed@promedmail.org>

[Golden Week occurs in the end of April, beginning of May and is a
confluence of 4 National Holidays in Japan. 29 Apr is Showa Day
(Showa no hi): the birthday of former Emperor Showa, who died in the
year 1989. 3 May is Constitution Day (Kenpo kinenbi): on this day in
1947, the new post-war constitution was put into effect. 4 May --
Greenery Day -- (Midori no hi): until 2006, Greenery Day used to be
celebrated on 29 Apr, the birthday of former Emperor Showa. The day
is dedicated to the environment and nature, because the emperor loved
plants and nature. Before being declared Greenery Day, 4 May used to
be a national holiday due to a law, which declares a day that falls
between 2 national holidays, a national holiday. 5 May -- Children's
Day -- (Kodomo no hi): the Boy's Festival (Tango no Sekku). Families
pray for the health and future success of their sons by hanging up
carp streamers and displaying samurai dolls, both of which symbolize
strength, power, and success in life. The Girl's Festival, is
celebrated on 3 Mar (excerpted from japan-guide.com
<http://www.japan-guide.com/e/e2282.html>).

As in many countries, during a weeklong holiday festival, there is
extensive movement of the Japanese population, so diseases that have
person-to-person transmission have a field day as the geographic
extent of the transmission is markedly facilitated in these countries
during these weeklong festivals. There is also extensive
international travel during these holiday periods so the possibility
of transmission of diseases, such as measles, to other countries is
also markedly increased,
with many nationals either returning to
their countries for the holiday, or taking advantage of a one-week
holiday to do international tourism or family visits. (As an aside,
this moderator will be leaving for Japan tomorrow in a non-official
capacity to spend Golden Week there and will be interested to see
what types of alerts may be issued.)

This newswire mentions an increase in reported cases in Tokyo and
Saitama Prefectures (Saitama Prefecture is adjacent to Tokyo; for a
map of Japan with administrative divisions see
<http://www.lib.utexas.edu/maps/middle_east_and_asia/japan_divisions.jpg>).

There is mention of school closings including elementary, junior, and
senior high school, and of increases in cases in adults... that
epidemiologic picture suggests there are many individuals who have
"slipped through the cracks" of the immunization program activities
in Japan. Measles is a vaccine preventable disease.
Receipt of 2
doses of potent vaccine (properly stored maintaining cold chain
temperature requirements from time of production through time of
administration of the vaccine) results in vaccine efficacies of 99
percent when the 1st dose is received at 12 months of age or older
(see Measles Pink Book Chapter at
<http://www.cdc.gov/Nip/publications/pink/meas.pdf>).

According to the Infectious Disease Surveillance Data
<http://idsc.nih.go.jp/idwr/kanja/weeklygraph/12measles-e.html>, as
of week 14 (the week of 2 Apr 2007), there appears to be a minor
increase in reported cases of measles nationwide, but at overall
rates lower than the past 10 years with the exception of 2006. While
the graph states it refers to sentinel case reports, the Y-axis is
not clear as to what is being measured (? actual case numbers,
population based rates). More information on the actual epidemiologic
situation of measles in Japan would be appreciated -- numbers of
cases, age distribution of cases, information on the vaccine history
of cases, control measures being implemented, type of virus
associated with increase, and possible geographic origin of
circulating virus). - Mod.MPP]:tiphat:

http://tinyurl.com/3a2xja
 
Re: MEASLES - JAPAN (TOKYO, SAITAMA): ALERT,pro med

i know this isnt anything to do with BF ,but wasnt there a measles epedemic somewhere just before the 1918 pandemic.?
 
Re: MEASLES - JAPAN (TOKYO, SAITAMA): ALERT,pro med

Japan's measles increase has Guam on alert
http://www.kuam.com/news/22214.aspx

An increase in measles cases in Japan has put healthcare providers and customs officers on alert. Territorial epidemiologist Dr. Robert Haddock warns that measles cases from the Land of the Rising Sun could be coming to Guam in the coming weeks as a measles epidemic is spreading the Tokyo and Saitama prefectures.

The National Institute of Infectious Disease warns the measles are highly contagious and the number of patients this year could surpass the 280,000 recorded in the year 2001. Of more concern is the upcoming golden week when Guam sees an influx of Japanese tourists.
....

jt
 
Re: MEASLES - JAPAN (TOKYO, SAITAMA): ALERT,pro med

Japan measles outbreak forces school closures
Last Updated 17/05/2007, 22:32:33
An outbreak of measles in Japan has forced several schools and universities in the Tokyo area to close temporarily.
The National Institute of Infectious Diseases says more than 10 times the average number of adults were reported infected in the first four months of the year.

Reports in the Japanese media have said a past dip in the immunisation rate caused by concerns over the possible side effects of the combined measles, mumps and rubella vaccination could be partly responsible.

But health authorities say the main infected age group is not those who would have been affected by the dip.
http://www.radioaustralia.net.au/news/stories/s1926245.htm
 
Re: MEASLES - JAPAN (TOKYO, SAITAMA): ALERT,pro med

The NIH of Japan provides authoritative update on measles.
On Pro med

MEASLES - JAPAN (03): TOKYO, CHIBA, SAITAMA, KANAGAWA

http://www.promedmail.org/pls/prome..._BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,37536

***********************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

Date: Wed 23 May 2007
From: Nobuhiko Okabe <okabenob@nih.go.jp>

We are, unfortunately, having an outbreak of measles in Japan,
particularly in the Kanto area, including Tokyo, Kanagawa, Saitama,
and Chiba Prefectures. The scale is much smaller than an outbreak in
2001, although the number of young patients is high. Many of them are
not immunized and [did not suffer from measles].

I would like to send the epidemiological data on the present
situation (19W 2007) of measles in Japan summarized by the Infectious
Disease Surveillance Center/NIID for your information. These data are
available weekly on our website
<http://idsc.nih.go.jp/disease/measles/index.html> as the "Infectious
Disease Weekly Report," but it is written in Japanese. The following
is the text officially carried on our website:

-----
Measles in Japan; week 19 [7-13 May 2007]

Infectious Disease Surveillance Center, National Institute of
Infectious Diseases, Tokyo, Japan

The National Institute of Infectious Disease (NIID) collects data
related to measles from approximately 3000 pediatric sentinels around
the country through the National Epidemiological Surveillance of
Infectious Diseases (NESID) -- based upon the Infectious Disease
Control Law -- and updates them in the Infectious Disease Weekly
Report (IDWR) each week.

According to the NESID, 214 cases (0.071 cases per sentinel) from 26
different prefectures were reported in week 19
(7-13 May 2007). This
is a huge increase compared to the previous week (88 cases, 0.030
cases per sentinel). Reported cases are apparently increasing in
South Kanto region (Tokyo, Saitama, Kanagawa, and Chiba prefecture)
and the case-reported area is expanding nationwide. The number of
cumulative cases reported from the pediatric sentinels between week 1
through 19 (2007) is 691 and already exceeded the total yearly
reported cases in 2005 and 2006 (537, 519 respectively). A closer
look at the data shows that the weekly reported number of cases
became highest in week 19 in all 5 of the highest case-reported
prefectures in 2007. There is an increase in the proportion of
reported cases among 10- to 14-year-olds (33.9 percent) compared to
the previous years, while it is decreasing among 0- to 4-year-olds
(39.7 percent).

In terms of measles among adolescents and adults (15 years old and
older), data is collected from approximately 450 hospital sentinels
across the country. The number of cases reported during week 19 was
53 (0.117 cases per sentinel) and was way higher than the previous
week (25 cases, 0.055 cases per sentinel). Tokyo has the highest
reported number of cases per week (19 cases), which has been
increasing since week 15 [9-15 Apr 2007]. The number of cumulative
cases reported from the hospital sentinels between week 1 through 19
2007 is 208 cases
, and more than 60 percent (132 cases) are reported
from South Kanto region, including Tokyo, Kanagawa, Saitama, and
Chiba Prefecture. However, reports from other regions are increasing
as well. More than 80 percent of cases were under 29 years of age.

The number of reported case of measles both from pediatric sentinels
and hospital sentinels has increased dramatically. The center of the
epidemic is in South Kanto, and cases are continuously increasing,
but the trend is being observed nationwide. Based on previous data
from NESID, measles cases reported in Japan peaked around week 19 in
pediatrics and week 20 in adolescents and adults. Thus, in a sense,
we may be observing the peak of the measles epidemic. However, the
cumulative number of reported cases is higher than in previous years,
and epidemic areas are expanding so that we need to pay close
attention to this transition.

Measles has been eradicated from several countries in the world, and
the World Health Organization Regional Office for the Western Pacific
(WPRO) aims to eradicate measles by 2012. Japan must work hard not to
be left behind by other countries and should avoid another large
measles outbreak like the one in 2001. To meet this goal, it is
important to pay attention to the trend in the NESID as well as to
conduct rapid and effective intervention to prevent further
outbreaks. Once a case of measles is diagnosed in schools or
institutional settings, it is desirable to practice accurate
intervention immediately
. Amid the current outbreak, those who have
never been vaccinated or who do not have any history of the disease
should receive measles vaccine immediately. As infants and young
children are most susceptible to measles virus, it is highly
recommended that they receive the measles vaccination, which 1st dose
is given at the age of one year old and the 2nd dose by the entrance
to elementary school.

--
Nobuhiko Okabe, MD., Ph.D.
Director of Infectious Disease Surveillance Center
National Institute of Infectious Diseases
1-23-1 Toyama Shinjuku
Tokyo 162-8640 Japan
<http://idsc.nih.go.jp/index-j.html>
<okabenob@nih.go.jp>


[ProMED-mail would like to thank Dr. Nobuhiko Okabe for the rapid
response in sending in this authoritative report on the measles
outbreak in Japan. From the report above, it does appear as though
the epicenter of the outbreak is still in the Kanto area, although
there are indications that the outbreak may be spreading
geographically
. - Mod.MPP]....

More links to historical posts on measles on the web site linked above.

Note that the reported number of cases of measles are only those from the sentinel providers and hospitals. It is not clear that Japan has a mandatory reporting and 100% tracking system as mandated in the USA.
JT
 
Re: MEASLES - JAPAN (TOKYO, SAITAMA): ALERT,pro med

See Pro Med post above. It alludes to room for improvement in epidemic control. The news article below highlights that issues we may take for granted in one country (eg school closures and the authority chain for decision making) are not so straightforward elsewhere.

http://www.yomiuri.co.jp/dy/national/20070524TDY03004.htm

Classes continue despite measles / Some universities say there are no standards for suspensions
The Yomiuri Shimbun
A measles outbreak is spreading among university students, but countermeasures differ from one university to the next because there is no firm standard on canceling classes in such circumstances. Some universities are canceling classes, while other continue to operate as usual despite having infected students. Some schools contend that if classes are canceled, students go out in public, further spreading the disease.
At Chiba University, 26 cases had been reported by Wednesday morning, but the university has not canceled classes.
Prof. Keiichi Nagao of the university's health management center said: "Unlike primary and middle school students, I'm not sure university students stay at their homes or boarding houses. Instead, they may go out and spread the epidemic." Nagao said that even if the university were to cancel classes, the infection could spread on the campus after classes resumed.
According to the National Institute of Infectious Diseases in Tokyo, a student from a university in the Tokyo metropolitan area returned home to Osaka while the university did not have classes and developed measles at home.
At Toyo University's Hakusan campus in Bunkyo Ward, Tokyo, 26 measles cases have been reported, but the university has not canceled classes.
The university said the outbreak is sporadic, and at present only three students are infected. "If there is a report of group infection, we'd like to consider canceling classes, but there isn't a standard for making that decision," a university official said. Some universities cancel classes if there is even one case reported.
Prof. Nobuo Murakami at Gifu University Hospital's Center for Nutrition Support and Infection Control said, "Measles is highly infectious, and if there is one sufferer in a class, all the class could be infected."
According to the Education, Science and Technology Ministry's School Health Education Division, decisions on temporary school closings and class cancellations are up to the schools' administrations.
There is no standard infection rate that prompts a school to close or cancel classes.
At Keio University, there are 14 students infected, and six others have been suspended from classes on suspicion of infection.
But the university is not considering canceling classes. An official of the university said, "We'd like to consider other measures while keeping an eye on the situation."
Tokyo University, where 11 cases have been reported, instructed infected individuals not to attend class for three days after their fever ends.
Sophia University, which canceled classes for a week when 10 cases were reported and resumed classes this week, still orders students who have fevers not to attend classes.
The university said, "If we continue suspending classes, it will become an obstacle to research and education activities. We don't think a one-week suspension can completely prevent the epidemic, but the measure let students know they shouldn't attend classes if they have measles."
(May. 24, 2007)
jt
 
Re: MEASLES - JAPAN (TOKYO, SAITAMA): ALERT,pro med

Taiwanese visitors warned of measles outbreak in Japan

Posted : Thu, 24 May 2007 11:32:01GMT

Taipei - Taiwan Thursday issued a travel advisory to be careful while visiting Japan due to a measles outbreak in that country. "Taiwan visitors should be on alert during their visits in Japan," said Foreign Ministry spokesman David Wang, referring to the outbreak in the Kanto region.

He asked potential visitors to check with Taiwan's Centre for Disease Control for further outbreak information before going.

Many universities and schools in Tokyo have suspended classes until the end of this month following the measles outbreak which started in Tokyo last week and has spread to Hokkaido and the north-eastern region of Japan.

More than a million Taiwanese visit Japan every year.

http://www.earthtimes.org/articles/show/65856.html
 
Re: MEASLES - JAPAN (TOKYO, SAITAMA): ALERT,pro med

Measles outbreak blamed on lack of youth exposure

The Yomiuri Shimbun

The rash of measles outbreaks among people in their 30s and younger is believed to have been sparked by weakened immunities to the disease as children have grown up lacking early exposure to the virus, the National Institute of Infectious Diseases said Tuesday.

The Kanto region has recently seen an outbreak of measles, with many universities calling off classes as a result, affecting at least 150,000 students, including Waseda University, which closed its main campus Monday.

Many are still wondering why there has been a sudden outbreak.

A prevailing characteristic this time around is that most of those infected are in their 20s and 30s, an age that some claim never received sufficient vaccinations as children.

However, according to a survey by the Health, Labor and Welfare Ministry in 2005, youth vaccination rates have been high, with more than 95 percent of people aged 2 to 19, 88.6 percent of people in their 20s and 85 percent of people in their 30s having been vaccinated, while just 52.3 percent of people aged 40 and over have been vaccinated.

Why is it the younger generation that is affected by this outbreak when so many of them have been vaccinated? The institute says that with so many people being vaccinated, measles outbreaks have dropped sharply, which means people have had less exposure to the virus and less opportunity to build up resistance.

About five percent of people cannot build an immunity with just once vaccination. These people, having since reached adulthood, are contributing to the current spread of the disease, according to the institute. Middle-aged people and the elderly have strong immunities as they have been through many outbreaks and are not as easily affected by this outbreak.

A single vaccination may not create immunity or could see a deterioration in immunity after several years. To prevent this, a double vaccination system was introduced from April last year. Children entering primary school are now subject to the double vaccination system. However, this measure is expected to take 10 years before the effects will be noticeable.

Therefore, the only preventive measure existing is protective inoculations. The institute advises people not vaccinated who have never been infected to get vaccinated.

Women wanting to have children in the future are especially advised to get vaccinated, because measles symptoms are more pronounced during pregnancy, risking the lives of both mother and child. However, women who are pregnant cannot receive vaccinations.

There is no cure for measles. Those infected need to avoid crowds and rest at home. The ministry says measles cannot be diagnosed in its early phase and people who have insufficient immunities may have a lack of symptoms such as rashes. The ministry is alerting people by telling them if cold-like symptoms appear to take precautions, such as wearing masks, so as not to pass the disease to others.

===

30% of vaccine used in 2 days


Stockpiles of measles vaccines decreased by about 160,000 doses in two days, more than 30 percent of the total stockpile, the Health, Labor and Welfare Ministry said.

The ministry added that there is plenty of vaccine and it will not run out soon. However, the ministry also has called for the wise distribution of vaccine, asking vaccination centers to "please efficiently prevent the disease from spreading by confirming whether a person has immunity before vaccinating."

There were about 450,000 individual doses of vaccine as of May 16, but the number was about 290,000 as of Friday. Most of the stockpile is believed to have been bought by medical institutions and local governments.

Major universities that have called off classes are: Nihon University from May 16 to 31, with 91 students infected, affecting 27,000 students; Komazawa University from May 17 to 30, 13 infected, about 16,000 affected; Tokyo University of Technology from May 17 to 26, five infected, about 6,000 affected; Wako University from May 18 to 24, five infected, about 3,500 affected; Seikei University from May 18 to 27, eight infected, about 8,000 affected; Chuo University from May 19 to 28, 13 infected, about 27,000 affected; Tokyo University of Agriculture from May 21 to June 3, eight infected, about 8,000 affected; and Waseda University from May 21 to 29, 30 infected, about 55,000 affected.

(May. 23, 2007)

http://www.yomiuri.co.jp/dy/features/science/20070523TDY04006.htm
 
Re: MEASLES - JAPAN (TOKYO, SAITAMA): ALERT,pro med

Testing for measles suspended due to shortage of lab reagents. Shortage of vaccine also noted. - JT

Antibody tests on measles to be suspended because of shortage of drugs

http://mdn.mainichi-msn.co.jp/national/news/20070526p2a00m0na022000c.html
Measles antibody tests will likely be totally suspended by Monday because of a shortage of drugs as the disease is raging mainly in the Tokyo metropolitan area, government sources said.
The revelations come about a week after the Health, Labor and Welfare Ministry instructed the prefectural governments across the country to conduct measles antibody tests before vaccinating people so as not to waste anti-measles vaccine."We failed to ask manufacturers how much vaccine is available. We'll try to grasp the situation as quickly as possible," a ministry official said.Those who remain immune to measles after being vaccinated or infected with the disease in the past do not need vaccinations. Antibody tests are necessary to see if people are still immune to the illness.
Following the recent epidemic of measles, clinical testing companies have been required to handle a massive number of antibody tests. One company that usually handles 50,000 antibody tests annually was flooded with requests for 10,000 such tests on Thursday alone.
As a result, drugs have been in short supply, forcing two major clinical testing firms to suspend antibody tests.
Not only children but numerous adults have been infected with measles. A total of 159 adults suffered the disease across the country between April 2 and May 13 this year, according to the National Institute of Infectious Diseases. (Mainichi)
May 26, 2007



Another story provides more details on the testing.

http://www.yomiuri.co.jp/dy/national/20070527TDY02013.htm

Reagent shortage stops tests
Several firms specializing in antibody tests have been forced to halt measles tests due to a shortage of the necessary reagents brought on by a sharp rise in requests for tests in response to the current outbreak in the Tokyo metropolitan area, it was learned Saturday.
As the outbreak is expected to last until June, many people may forego the tests and just get vaccinated, which may lead to a run on measles vaccine. People who are sufficiently immune to the measles due to having had it or a past vaccination need not be vaccinated.
To test for immunity, blood samples taken at medical institutions are sent to testing firms.
According to one major firm, the number of requests for antibody tests began to increase around the end of Golden Week holidays in early May, before making a drastic jump in the middle of the month.
There were on average about 100 requests for the enzyme immunoassay (EIA) test, the main method for testing the antibodies. In mid-May, however, the number surged to about 7,000 requests, according to the firm.
As a result, the company's reagent stocks have dried up, leading it to discontinue their tests, even those performed under a different method.
At another test firm, the number of requests for antibody tests, which had been around about 1,000 a day, suddenly increased to about 10,000 last week.
(May. 27, 2007)
 
Re: MEASLES - JAPAN (TOKYO, SAITAMA): ALERT,pro med

In the US there is aggressive use of case contact tracing and even quarantine to extinguish the spread of highly infectious diseases such as measles.
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5341a3.htm

Once the number of cases gets to a certain point, or if case tracking does not begin with the initial wave, then we would be in a situation similar to Japan.

Note also that even though we are tracking the media reports of measles in Japan, 4 of the 5 reported US outbreaks are linked to travelers from India. Only 1 US case of measles is linked to a traveler from Japan (the San Antonio cluster) Measles in India is not in the news, and the US reports have not traced the area of origin.

JT
 
Re: MEASLES - JAPAN (TOKYO, SAITAMA): ALERT,pro med

More Japanese universities close campuses as measles outbreak spreads

Published: May 27, 2007

TOKYO: A widening outbreak of measles among college students mostly in the Tokyo area forced another Japanese university to close one of its campuses on Sunday to control the spread of the virus.

Tokyo's Hosei University announced it was closing a second of its three campuses for eight days after 14 students were confirmed to have the illness. The university closed another campus last Thursday.

About a dozen universities in the Tokyo area, together with a handful of other schools around the country, have suspended classes — generally for about one week — since mid-April because of measles outbreaks, according to media reports.

The National Institute of Infectious Diseases said 623 people are known to have contracted the illness between Feb. 27 and May 27, compared to only 18 during the same period last year.

The reasons why this year's outbreak has been so severe were not immediately clear. The Asahi newspaper, citing unidentified experts, said a previous decline in the number of measles outbreaks may have lessened the efficacy of childhood vaccinations among the students, as exposure to the virus strengthens their effect.


NIID said April to June were likely to be peak months for the virus to spread because of the concentration of graduation and matriculation ceremonies during that time.

The Japanese school year ends in March and resumes in April.

Phone calls to the Health Ministry rang unanswered Sunday. NIID officials were not immediately available for comment.

http://www.iht.com/articles/ap/2007/05/27/asia/AS-GEN-Japan-Measles.php
 
Re: MEASLES - JAPAN (TOKYO, SAITAMA): ALERT,pro med

Number of measles patients hits record high

The number of measles patients aged over 15 who were reported by medical institutions from May 14 to 20 reached 68, a record high since an institute started collecting data in 1999, officials said.

The National Institute of Infectious Diseases, which receives data on the number of measles patients from some 450 hospitals across Japan, has warned university students not to visit busy places as many institutions have stopped classes in the wake of the outbreak.

The institute began receiving reports on the number of measles patients from hospitals in 1999. The largest weekly number of measles patients reported by hospitals had been 56, which was recorded from May 14 to 20, 2001.

Meanwhile, the number of people over 15 years old who have caught measles stands at 286 so far this year, 116 of them from Tokyo.

During the same period until late May, the number reached 404 in 2001. But officials from the institute suspect that this year's number of measles patients would surpass the 2001 figure.

They said that people who haven't been vaccinated against measles are likely to be infected. But they added that even vaccinated people could become infected if their immunity begins to weaken.

Those people who are vaccinated but become infected show only minor symptoms and are likely to be a source of infection to other people, the officials said. (Mainichi)

http://mdn.mainichi-msn.co.jp/national/news/20070529p2a00m0na015000c.html
 
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