Low-Pathogenic H5 Subtype Influenza Viruses from Eurasia: Implications for the Origin

[Anne]

[SIZE=-1]Journal of Virology, July 2007, p. 7529-7539, Vol. 81, No. 14
0022-538X/07/$08.00+0 doi:10.1128/JVI.00327-07
Copyright ? 2007, American Society for Microbiology. All Rights Reserved.[/SIZE]
Characterization of Low-Pathogenic H5 Subtype Influenza Viruses from Eurasia: Implications for the Origin of Highly Pathogenic H5N1 Viruses<sup>

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L. Duan,¹^,2 L. Campitelli,³ X. H. Fan,¹ Y. H. C. Leung,¹ D. Vijaykrishna,¹^,2 J. X. Zhang,¹^,2 I. Donatelli,³ M. Delogu,⁴ K. S. Li,² E. Foni,⁵ C. Chiapponi,⁵ W. L. Wu,¹^,2 H. Kai,¹^,2 R. G. Webster,¹^,6 K. F. Shortridge,¹^,2 J. S. M. Peiris,¹^,2 Gavin J. D. Smith,¹^,2 H. Chen,¹^,2^* and Y. Guan¹^,2^* State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, SAR, China,¹ International Institute of Infection and Immunity, Shantou University, Shantou, Guangdong 515031, China,² Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanit?, Viale Regina Elena 299, Rome, Italy,³ Department of Public Health and Animal Pathology, Faculty of Veterinary Medicine, University of Bologna, Ozzano Emilia (BO), Italy,⁴ Istituto Zooprofilattico Sperimentale of Lombardia and Emilia, Parma, Italy,⁵ Virology Division, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38015⁶
Received 14 February 2007/ Accepted 3 May 2007
<!-- ABS --> Highly pathogenic avian influenza (HPAI) H5N1 viruses are nowendemic in many Asian countries, resulting in repeated outbreaksin poultry and increased cases of human infection. The immediateprecursor of these HPAI viruses is believed to be A/goose/Guangdong/1/96(Gs/GD)-like H5N1 HPAI viruses first detected in Guangdong,China, in 1996. From 2000 onwards, many novel reassortant H5N1influenza viruses or genotypes have emerged in southern China.However, precursors of the Gs/GD-like viruses and their subsequentreassortants have not been fully determined. Here we characterizelow-pathogenic avian influenza (LPAI) H5 subtype viruses isolatedfrom poultry and migratory birds in southern China and Europefrom the 1970s to the 2000s. Phylogenetic analyses revealedthat Gs/GD-like virus was likely derived from an LPAI H5 virusin migratory birds. However, its variants arose from multiplereassortments between Gs/GD-like virus and viruses from migratorybirds or with those Eurasian viruses isolated in the 1970s.It is of note that unlike HPAI H5N1 viruses, those recent LPAIH5 viruses have not become established in aquatic or terrestrialpoultry. Phylogenetic analyses revealed the dynamic nature ofthe influenza virus gene pool in Eurasia with repeated transmissionsbetween the eastern and western extremities of the continent.The data also show reassortment between influenza viruses fromdomestic and migratory birds in this region that has contributedto the expanded diversity of the influenza virus gene pool amongpoultry in Eurasia.

 

[gsgs]

Re: Low-Pathogenic H5 Subtype Influenza Viruses from Eurasia: Implications for the Or

Re: Low-Pathogenic H5 Subtype Influenza Viruses from Eurasia: Implications for the Or

do they say the virus evolves in poultry and then spreads back to wild birds ?

 

[Anne]

Re: Low-Pathogenic H5 Subtype Influenza Viruses from Eurasia: Implications for the Or

Re: Low-Pathogenic H5 Subtype Influenza Viruses from Eurasia: Implications for the Or

and back again to poultry etc..