tetano
Editor, Senior Moderator
J Infect Dis. 2016 Dec 22. pii: jiw619. doi: 10.1093/infdis/jiw619. [Epub ahead of print]
[h=1]Long-term maintenance of the influenza-specific cross-reactive memory CD4+ T-cell responses following repeated annual influenza vaccination.[/h] Trieu MC[SUP]1,[/SUP][SUP]2[/SUP], Zhou F[SUP]1,[/SUP][SUP]2[/SUP], Lartey S[SUP]1,[/SUP][SUP]2[/SUP], Jul-Larsen ?[SUP]1,[/SUP][SUP]2[/SUP], Mjaaland S[SUP]2,[/SUP][SUP]3[/SUP], Sridhar S[SUP]4[/SUP], Cox RJ[SUP]5,[/SUP][SUP]2,[/SUP][SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Annual vaccination for healthcare workers and other high-risk groups is the mainstay of the public health strategy to combat influenza. Inactivated influenza vaccines confer protection by inducing neutralizing antibodies efficiently against homologous and closely-matched virus strains. In the absence of neutralizing antibodies, cross-reactive T-cells have been shown to limit disease severity. However, animal studies and a study in immunocompromised children suggested that repeated vaccination hampers the CD8[SUP]+[/SUP] T-cells. Yet, the impact of repeated annual influenza vaccination on both cross-reactive CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T-cells has not been explored, particularly in healthy adults.
[h=4]METHODS:[/h] We assembled a unique cohort of healthcare workers who received a single AS03-adjuvanted H1N1pdm09 vaccine in 2009 and subsequently either repeated annual vaccination or no further vaccination during 2010-2013. Blood samples were collected prior to the influenza season or vaccination to assess antibody and T-cell responses.
[h=4]RESULTS:[/h] Antibody titers to H1N1pdm09 persisted above the protective level in both the repeated and single vaccination groups. The IFN- [SUP]+[/SUP] and multifunctional CD4[SUP]+[/SUP] T-cell responses were maintained in the repeated group but declined significantly in the single vaccination group. The IFN- [SUP]+[/SUP]CD8[SUP]+[/SUP] T-cells remained stable in both groups.
[h=4]CONCLUSIONS:[/h] This study provides the immunological evidence-base for continuing annual influenza vaccination in adults.
? The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] CD4; CD8; Influenza vaccination; T-cell; antibody; healthcare worker; immune response
PMID: 28007925 DOI: 10.1093/infdis/jiw619
[PubMed - as supplied by publisher]
[h=1]Long-term maintenance of the influenza-specific cross-reactive memory CD4+ T-cell responses following repeated annual influenza vaccination.[/h] Trieu MC[SUP]1,[/SUP][SUP]2[/SUP], Zhou F[SUP]1,[/SUP][SUP]2[/SUP], Lartey S[SUP]1,[/SUP][SUP]2[/SUP], Jul-Larsen ?[SUP]1,[/SUP][SUP]2[/SUP], Mjaaland S[SUP]2,[/SUP][SUP]3[/SUP], Sridhar S[SUP]4[/SUP], Cox RJ[SUP]5,[/SUP][SUP]2,[/SUP][SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Annual vaccination for healthcare workers and other high-risk groups is the mainstay of the public health strategy to combat influenza. Inactivated influenza vaccines confer protection by inducing neutralizing antibodies efficiently against homologous and closely-matched virus strains. In the absence of neutralizing antibodies, cross-reactive T-cells have been shown to limit disease severity. However, animal studies and a study in immunocompromised children suggested that repeated vaccination hampers the CD8[SUP]+[/SUP] T-cells. Yet, the impact of repeated annual influenza vaccination on both cross-reactive CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T-cells has not been explored, particularly in healthy adults.
[h=4]METHODS:[/h] We assembled a unique cohort of healthcare workers who received a single AS03-adjuvanted H1N1pdm09 vaccine in 2009 and subsequently either repeated annual vaccination or no further vaccination during 2010-2013. Blood samples were collected prior to the influenza season or vaccination to assess antibody and T-cell responses.
[h=4]RESULTS:[/h] Antibody titers to H1N1pdm09 persisted above the protective level in both the repeated and single vaccination groups. The IFN- [SUP]+[/SUP] and multifunctional CD4[SUP]+[/SUP] T-cell responses were maintained in the repeated group but declined significantly in the single vaccination group. The IFN- [SUP]+[/SUP]CD8[SUP]+[/SUP] T-cells remained stable in both groups.
[h=4]CONCLUSIONS:[/h] This study provides the immunological evidence-base for continuing annual influenza vaccination in adults.
? The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] CD4; CD8; Influenza vaccination; T-cell; antibody; healthcare worker; immune response
PMID: 28007925 DOI: 10.1093/infdis/jiw619
[PubMed - as supplied by publisher]