tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2011 Nov 9. [Epub ahead of print]
Long-term antibody and immune memory response induced by pulmonary delivery of influenza ISCOMATRIXTM vaccine.
Vujanic A, Snibson KJ, Wee JL, Edwards SJ, Pearse MJ, Scheerlinck JP, Sutton P.
Source
Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Melbourne, VIC 3010, Australia.
Abstract
BACKGROUND:
Pulmonary delivery of an influenza ISCOMATRIX? adjuvant vaccine induces a strong systemic and mucosal antibody response. As, for utility in humans an influenza vaccine needs to induce immunological memory that lasts at least one year, we examined the longevity of the immune response induced by such a pulmonary vaccination, with and without antigen challenge.
METHODS:
Sheep were vaccinated in their deep lung with an influenza ISCOMATRIX? vaccine and serum and lung antibody levels quantified for up to one year. The immune memory response to these vaccinations was determined following antigen challenge of lung delivery of influenza, 6 months and one year post-vaccination.
RESULTS:
Pulmonary vaccination of sheep with an influenza ISCOMATRIX? vaccine induced antigen-specific antibodies in both sera and lungs, that were detectable until 6 months post-immunisation. Importantly, a memory recall response following antigenic challenge was detected 12 months post lung-vaccination, including the induction of functional antibodies with haemagglutinin inhibition activity.
CONCLUSION:
Pulmonary delivery of an influenza ISCOMATRIX? vaccine induces long-lived influenza-specific antibody and memory response of suitable length for annual vaccination against influenza.
PMID:
22072721
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22072721
Long-term antibody and immune memory response induced by pulmonary delivery of influenza ISCOMATRIXTM vaccine.
Vujanic A, Snibson KJ, Wee JL, Edwards SJ, Pearse MJ, Scheerlinck JP, Sutton P.
Source
Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Melbourne, VIC 3010, Australia.
Abstract
BACKGROUND:
Pulmonary delivery of an influenza ISCOMATRIX? adjuvant vaccine induces a strong systemic and mucosal antibody response. As, for utility in humans an influenza vaccine needs to induce immunological memory that lasts at least one year, we examined the longevity of the immune response induced by such a pulmonary vaccination, with and without antigen challenge.
METHODS:
Sheep were vaccinated in their deep lung with an influenza ISCOMATRIX? vaccine and serum and lung antibody levels quantified for up to one year. The immune memory response to these vaccinations was determined following antigen challenge of lung delivery of influenza, 6 months and one year post-vaccination.
RESULTS:
Pulmonary vaccination of sheep with an influenza ISCOMATRIX? vaccine induced antigen-specific antibodies in both sera and lungs, that were detectable until 6 months post-immunisation. Importantly, a memory recall response following antigenic challenge was detected 12 months post lung-vaccination, including the induction of functional antibodies with haemagglutinin inhibition activity.
CONCLUSION:
Pulmonary delivery of an influenza ISCOMATRIX? vaccine induces long-lived influenza-specific antibody and memory response of suitable length for annual vaccination against influenza.
PMID:
22072721
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22072721