tetano
Editor, Senior Moderator
J Infect Dis. 2019 Jun 27. pii: jiz321. doi: 10.1093/infdis/jiz321. [Epub ahead of print]
[h=1]Live attenuated influenza vaccine induces tonsillar follicular T helper cell responses that correlate with antibody induction.[/h] Lartey S[SUP]1[/SUP], Zhou F[SUP]1,[/SUP][SUP]2[/SUP], Brokstad KA[SUP]3[/SUP], Mohn KG[SUP]1[/SUP], Slettevoll SA[SUP]1[/SUP], Pathirana RD[SUP]1[/SUP], Cox RJ[SUP]1,[/SUP][SUP]2,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza remains a major threat to public health. Live attenuated influenza vaccines (LAIV) have been shown to be effective, particularly in children. Follicular T helper (TFH) cells provide B-cell help and are crucial for generating long-term humoral immunity. However the role of TFH-cells in LAIV induced immune responses is unknown. Here we report that LAIV induced early (3-7 days post-vaccination) activation of tonsillar follicles and influenza-specific TFH-cell (CXCR5+CD57+CD4+ T-cell) responses in children, and to a lesser extent in adults. Serological analyses showed that LAIV elicited rapid (day 14) and long-term (up to 1 year post-vaccination) antibody responses (HI, influenza-specific IgG) in children, but not adults. There was an inverse correlation between pre-existing influenza-specific salivary IgA concentrations and tonsillar TFH-cell responses, and a positive correlation between tonsillar TFH-cell and systemic IgG induction after LAIV. Together, our data demonstrate an important role of tonsillar TFH-cells in LAIV-induced immunity in humans.
? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.
[h=4]KEYWORDS:[/h] Influenza; LAIV; TFH-cells; antibody responses; children; tonsils
PMID: 31250024 DOI: 10.1093/infdis/jiz321
[h=1]Live attenuated influenza vaccine induces tonsillar follicular T helper cell responses that correlate with antibody induction.[/h] Lartey S[SUP]1[/SUP], Zhou F[SUP]1,[/SUP][SUP]2[/SUP], Brokstad KA[SUP]3[/SUP], Mohn KG[SUP]1[/SUP], Slettevoll SA[SUP]1[/SUP], Pathirana RD[SUP]1[/SUP], Cox RJ[SUP]1,[/SUP][SUP]2,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza remains a major threat to public health. Live attenuated influenza vaccines (LAIV) have been shown to be effective, particularly in children. Follicular T helper (TFH) cells provide B-cell help and are crucial for generating long-term humoral immunity. However the role of TFH-cells in LAIV induced immune responses is unknown. Here we report that LAIV induced early (3-7 days post-vaccination) activation of tonsillar follicles and influenza-specific TFH-cell (CXCR5+CD57+CD4+ T-cell) responses in children, and to a lesser extent in adults. Serological analyses showed that LAIV elicited rapid (day 14) and long-term (up to 1 year post-vaccination) antibody responses (HI, influenza-specific IgG) in children, but not adults. There was an inverse correlation between pre-existing influenza-specific salivary IgA concentrations and tonsillar TFH-cell responses, and a positive correlation between tonsillar TFH-cell and systemic IgG induction after LAIV. Together, our data demonstrate an important role of tonsillar TFH-cells in LAIV-induced immunity in humans.
? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.
[h=4]KEYWORDS:[/h] Influenza; LAIV; TFH-cells; antibody responses; children; tonsils
PMID: 31250024 DOI: 10.1093/infdis/jiz321