tetano
Editor, Senior Moderator
Life Sci
. 2020 Dec 19;118919.
doi: 10.1016/j.lfs.2020.118919. Online ahead of print.
DNA vaccines against COVID-19: Perspectives and challenges
Marcelle Moura Silveira[SUP] 1 [/SUP], Gustavo Mar?al Schmidt Garcia Moreira[SUP] 2 [/SUP], Marcelo Mendon?a[SUP] 3 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is associated with several fatal cases worldwide. The rapid spread of this pathogen and the increasing number of cases highlight the urgent development of vaccines. Among the technologies available for vaccine development, DNA vaccination is a promising alternative to conventional vaccines. Since its discovery in the 1990s, it has been of great interest because of its ability to elicit both humoral and cellular immune responses while showing relevant advantages regarding producibility, stability, and storage. This review aimed to summarize the current knowledge and advancements on DNA vaccines against COVID-19, particularly those in clinical trials.
Keywords: COVID-19; Coronavirus; DNA vaccine; Immunization; Nucleic acid-based vaccines.
. 2020 Dec 19;118919.
doi: 10.1016/j.lfs.2020.118919. Online ahead of print.
DNA vaccines against COVID-19: Perspectives and challenges
Marcelle Moura Silveira[SUP] 1 [/SUP], Gustavo Mar?al Schmidt Garcia Moreira[SUP] 2 [/SUP], Marcelo Mendon?a[SUP] 3 [/SUP]
Affiliations
- PMID: 33352173
- DOI: 10.1016/j.lfs.2020.118919
Abstract
The coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is associated with several fatal cases worldwide. The rapid spread of this pathogen and the increasing number of cases highlight the urgent development of vaccines. Among the technologies available for vaccine development, DNA vaccination is a promising alternative to conventional vaccines. Since its discovery in the 1990s, it has been of great interest because of its ability to elicit both humoral and cellular immune responses while showing relevant advantages regarding producibility, stability, and storage. This review aimed to summarize the current knowledge and advancements on DNA vaccines against COVID-19, particularly those in clinical trials.
Keywords: COVID-19; Coronavirus; DNA vaccine; Immunization; Nucleic acid-based vaccines.