Leucine-rich, glioma-inactivated 1{LGI1} Identified as Autoantigen Associated With Limbic Encephalitis

[Emily]

http://www.pharmatutor.org/pharma-news/july10/leucine-rich-glioma-inactivated-identifies-in-limbic-encephalitis

Leucine-rich, glioma-inactivated 1{LGI1} Identified as Autoantigen Associated With Limbic Encephalitis

[snip]

Josep Dalmau, MD, PhD, with the Department of Neurology, University of Pennsylvania, Philadelphia, and colleagues reported the findings in The Lancet Neurology, published online June 28, 2010.

On the basis of their findings, the study authors suggest that limbic encephalitis should now be classified as an autoimmune synaptic encephalopathy, similar to those associated with NMDA or AMPA receptor antibodies.....

Implications for other diseases such as epileptic seizures, mood disorders, and neuropsychological symptoms, such as memory disturbance, are discussed in the article.