https://www.frontiersin.org/articles/10.3389/fpubh.2020.581569/full
Front. Public Health, 20 October 2020 |
https://doi.org/10.3389/fpubh.2020.581569
Lethal Pneumonia Cases in Mojiang Miners (2012) and the Mineshaft Could Provide Important Clues to the Origin of SARS-CoV-2
Monali C. Rahalkar[SUP]1[/SUP][SUP]*[/SUP] and
Rahul A. Bahulikar[SUP]2[/SUP]
- [SUP]1[/SUP]C2, Bioenergy Group, MACS Agharkar Research Institute, Pune, India
- [SUP]2[/SUP]BAIF Development Research Foundation, Central Research Station, Pune, India
With the COVID-19 pandemic reaching its worst heights, people are interested in the origin of SARS-CoV-2. This study started with two important questions: first, were there any similar atypical pneumonia outbreaks, even on a smaller level, reported between SARS in 2004 and COVID-19 in 2019/20 in China. Second, examining the beta-coronavirus most closely related to date with SARS-CoV-2 at the genome sequence level, strain RaTG13 (CoV4991), which was sampled from a horseshoe bat in Yunnan province, we asked where exactly did it come from. It was found that RaTG13/CoV4991 was collected from Tongguan mineshaft in Mojiang, Yunnan, China, in 2013. Surprisingly, the same mineshaft was also associated with a severe pneumonia-like illness in miners in 2012 killing three of the six miners. A Master's thesis (in the Chinese language) was found on the cnki.net website which described in detail the severe illness in miners. The thesis concluded that a SARS-like CoV originating from Chinese horseshoe bats (
Rhinolophus) was the predicted causative agent. The cases were remotely monitored by a prominent pulmonologist in China. Retrospective analysis of the pneumonia cases shows striking similarities with COVID-19. Bilateral pneumonia, vascular complications like pulmonary thromboembolism, and secondary infections are the main similarities. The treatment regimes were similar to the current treatments for COVID-19. We propose that the Mojiang mineshaft miners' illness could provide important clues to the origin of SARS-CoV-2. These cases should be studied by various academicians, researchers, and medical professionals as many important questions are raised in this context.
One Line Summary
Lethal pneumonia in Mojiang miners and the mine could provide an important link to the research investigating the origin of SARS-CoV-2.
