Lancet: Why H7N9 seems to be more readily transmitted from poultry to people than H5N1 is still unclear

[sharon sanders]

hat tip @kelle569

The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities
Kelvin KW To, FRCPatha, ?, Jasper FW Chan, FRCPatha, ?, Honglin Chen, PhDa, c, Lanjuan Li, MDb, c, Dr Kwok-Yung Yuen, MDa, c, Corresponding author contact information, E-mail the corresponding author


Summary
Infection with either influenza A H5N1 virus in 1997 or avian influenza A H7N9 virus in 2013 caused severe pneumonia that did not respond to typical or atypical antimicrobial treatment, and resulted in high mortality. Both viruses are reassortants with internal genes derived from avian influenza A H9N2 viruses that circulate in Asian poultry. Both viruses have genetic markers of mammalian adaptation in their haemagglutinin and polymerase PB2 subunits, which enhanced binding to human-type receptors and improved replication in mammals, respectively. Hong Kong (affected by H5N1 in 1997) and Shanghai (affected by H7N9 in 2013) are two rapidly flourishing cosmopolitan megacities that were increasing in human population and poultry consumption before the outbreaks. Both cities are located along the avian migratory route at the Pearl River delta and Yangtze River delta. Whether the widespread use of the H5N1 vaccine in east Asia?with suboptimum biosecurity measures in live poultry markets and farms?predisposed to the emergence of H7N9 or other virus subtypes needs further investigation. Why H7N9 seems to be more readily transmitted from poultry to people than H5N1 is still unclear.


http://www.sciencedirect.com/science/article/pii/S1473309913701671

 

[Giuseppe]

Re: Lancet: Why H7N9 seems to be more readily transmitted from poultry to people than H5N1 is still unclear

[Source: The Lancet Infectious Diseases, full page: (LINK). Abstract, edited.]


The Lancet Infectious Diseases, Volume 13, Issue 9, Pages 809 - 821, September 2013

doi:10.1016/S1473-3099(13)70167-1

Copyright ? 2013 Elsevier Ltd All rights reserved.

The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities

Original Text


Kelvin KW To FRCPath a ?, Jasper FW Chan FRCPath a ?, Honglin Chen PhD a c, Lanjuan Li MD b c, Dr Kwok-Yung Yuen MD a c


Summary

Infection with either influenza A H5N1 virus in 1997 or avian influenza A H7N9 virus in 2013 caused severe pneumonia that did not respond to typical or atypical antimicrobial treatment, and resulted in high mortality. Both viruses are reassortants with internal genes derived from avian influenza A H9N2 viruses that circulate in Asian poultry. Both viruses have genetic markers of mammalian adaptation in their haemagglutinin and polymerase PB2 subunits, which enhanced binding to human-type receptors and improved replication in mammals, respectively. Hong Kong (affected by H5N1 in 1997) and Shanghai (affected by H7N9 in 2013) are two rapidly flourishing cosmopolitan megacities that were increasing in human population and poultry consumption before the outbreaks. Both cities are located along the avian migratory route at the Pearl River delta and Yangtze River delta. Whether the widespread use of the H5N1 vaccine in east Asia?with suboptimum biosecurity measures in live poultry markets and farms?predisposed to the emergence of H7N9 or other virus subtypes needs further investigation. Why H7N9 seems to be more readily transmitted from poultry to people than H5N1 is still unclear.
________

a State Key Laboratory for Emerging Infectious Diseases, Research Centre of Infection and Immunology, Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; b State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; c Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China

Correspondence to: Dr Kwok-Yung Yuen, Carol Yu Centre for Infection and Division of Infectious Diseases, Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, China

? These authors contributed equally


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