tetano
Editor, Senior Moderator
Lancet Reg Health Am
. 2021 Aug 13;100038.
doi: 10.1016/j.lana.2021.100038. Online ahead of print.
Patterns and descriptors of COVID-19 testing and lab-confirmed COVID-19 incidence in Manitoba, Canada, March 2020-May 2021: A population-based study
Christiaan H Righolt[SUP] 1 [/SUP], Geng Zhang[SUP] 1 [/SUP], Emrah Sever[SUP] 1 [/SUP], Krista Wilkinson[SUP] 1 [/SUP], Salaheddin M Mahmud[SUP] 1 [/SUP]
Affiliations
Abstract
Background: We studied lab-confirmed COVID-19 infection (LCCI) testing, incidence, and severity.
Methods: We included all Manitoba residents and limited our severity analysis to LCCI patients. We calculated testing, incidence and vaccination rates between March 8, 2020 and June 1, 2021. We estimated the association between patient characteristics and testing (rate ratio [RR]; Poisson regression), including the reason for testing (screening, symptomatic, contact/outbreak asymptomatic), incidence (hazard ratio
; Cox regression), and severity (prevalence ratio [PR], Cox regression).
Findings: The overall testing rate during the second/third wave was 570/1,000 person-years, with an LCCI rate of 50/1,000 person-years. The secondary attack rate during the second/third wave was 16%. Across regions, young children (<10) had the lowest positivity for symptomatic testing, the highest positivity for asymptomatic testing, and the highest risk of LCCI as asymptomatic contact. People in the lowest income quintile had the highest risk of LCCI, 1.3-6x the hazard of those in the highest income quintile. Long-term care (LTC) residents were particularly affected in the second wave with HRs>10 for asymptomatic residents.
Interpretation: Although the severity of LCCI in children was low, they have a high risk of asymptomatic positivity. The groups most vulnerable to LCCI, who should remain a focus of public health, were residents of Manitoba's North, LTC facilities, and low-income neighbourhoods.
Funding: Canada Research Chair Program.
Keywords: COVID-19; Coronavirus disease 2019; incidence; lab-confirmed COVID-19 infection; super-spreaders; testing.
. 2021 Aug 13;100038.
doi: 10.1016/j.lana.2021.100038. Online ahead of print.
Patterns and descriptors of COVID-19 testing and lab-confirmed COVID-19 incidence in Manitoba, Canada, March 2020-May 2021: A population-based study
Christiaan H Righolt[SUP] 1 [/SUP], Geng Zhang[SUP] 1 [/SUP], Emrah Sever[SUP] 1 [/SUP], Krista Wilkinson[SUP] 1 [/SUP], Salaheddin M Mahmud[SUP] 1 [/SUP]
Affiliations
- PMID: 34409400
- PMCID: PMC8360706
- DOI: 10.1016/j.lana.2021.100038
Abstract
Background: We studied lab-confirmed COVID-19 infection (LCCI) testing, incidence, and severity.
Methods: We included all Manitoba residents and limited our severity analysis to LCCI patients. We calculated testing, incidence and vaccination rates between March 8, 2020 and June 1, 2021. We estimated the association between patient characteristics and testing (rate ratio [RR]; Poisson regression), including the reason for testing (screening, symptomatic, contact/outbreak asymptomatic), incidence (hazard ratio
; Cox regression), and severity (prevalence ratio [PR], Cox regression).
Findings: The overall testing rate during the second/third wave was 570/1,000 person-years, with an LCCI rate of 50/1,000 person-years. The secondary attack rate during the second/third wave was 16%. Across regions, young children (<10) had the lowest positivity for symptomatic testing, the highest positivity for asymptomatic testing, and the highest risk of LCCI as asymptomatic contact. People in the lowest income quintile had the highest risk of LCCI, 1.3-6x the hazard of those in the highest income quintile. Long-term care (LTC) residents were particularly affected in the second wave with HRs>10 for asymptomatic residents.
Interpretation: Although the severity of LCCI in children was low, they have a high risk of asymptomatic positivity. The groups most vulnerable to LCCI, who should remain a focus of public health, were residents of Manitoba's North, LTC facilities, and low-income neighbourhoods.
Funding: Canada Research Chair Program.
Keywords: COVID-19; Coronavirus disease 2019; incidence; lab-confirmed COVID-19 infection; super-spreaders; testing.