tetano
Editor, Senior Moderator
[h=1]Long-term clinical prognosis of human infections with avian influenza A(H7N9) viruses in China after hospitalization[/h]
Open AccessPublished:February 18, 2020DOI:https://doi.org/10.1016/j.eclinm.2020.100282
Open AccessPublished:February 18, 2020DOI:https://doi.org/10.1016/j.eclinm.2020.100282
[h=2]ABSTRACT[/h] [h=3]Background[/h] Mainland China has experienced five epidemics of human cases of avian influenza A(H7N9) virus infection since 2013. We conducted a prospective study to assess long-term clinical, pulmonary function testing, and chest computed tomography (CT) imaging findings after patients were discharged from hospital.
[h=3]Methods[/h] A(H7N9) survivors in five provinces and one municipality underwent follow-up visits from August 2013 to September 2018, at three, six, and 12 months after illness onset, and a subset was also assessed at 18 and 64 months after onset. Thirteen patients were enrolled from the first A(H7N9) epidemic in 2013, 36 from the 2013-2014 second epidemic, and 12 from the 2016-2017 fifth epidemic. At each visit, A(H7N9) survivors received a medical examination, including the mMRC (modified Medical Research Council) dyspnea scale assessment, chest auscultation, pulmonary function testing and chest CT scans.
[h=3]Findings[/h] The median age of 61 A(H7N9) survivors was 50 years. The cumulative rate of pulmonary dysfunction was 38?5% and 78?2% for chest CT scan abnormalities at the end of follow-up. Restrictive ventilation dysfunction was common during follow-up. Mild dyspnea was documented at three to 12-month follow-up visits.
[h=3]Interpretation[/h] Patients who survived severe illness from A(H7N9) virus infection had evidence of persistent lung damage and long-term pulmonary dysfunction.
[h=3]Funding[/h] National Science Fund for Distinguished Young Scholars (grant number 81525023); Program of Shanghai Academic/Technology Research Leader (grant number 18XD1400300); National Science and Technology Major Project of China (grant numbers 2017ZX10103009-005, 2018ZX10201001-010).
full article
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30026-2/fulltext
Open AccessPublished:February 18, 2020DOI:https://doi.org/10.1016/j.eclinm.2020.100282
Open AccessPublished:February 18, 2020DOI:https://doi.org/10.1016/j.eclinm.2020.100282
[h=2]ABSTRACT[/h] [h=3]Background[/h] Mainland China has experienced five epidemics of human cases of avian influenza A(H7N9) virus infection since 2013. We conducted a prospective study to assess long-term clinical, pulmonary function testing, and chest computed tomography (CT) imaging findings after patients were discharged from hospital.
[h=3]Methods[/h] A(H7N9) survivors in five provinces and one municipality underwent follow-up visits from August 2013 to September 2018, at three, six, and 12 months after illness onset, and a subset was also assessed at 18 and 64 months after onset. Thirteen patients were enrolled from the first A(H7N9) epidemic in 2013, 36 from the 2013-2014 second epidemic, and 12 from the 2016-2017 fifth epidemic. At each visit, A(H7N9) survivors received a medical examination, including the mMRC (modified Medical Research Council) dyspnea scale assessment, chest auscultation, pulmonary function testing and chest CT scans.
[h=3]Findings[/h] The median age of 61 A(H7N9) survivors was 50 years. The cumulative rate of pulmonary dysfunction was 38?5% and 78?2% for chest CT scan abnormalities at the end of follow-up. Restrictive ventilation dysfunction was common during follow-up. Mild dyspnea was documented at three to 12-month follow-up visits.
[h=3]Interpretation[/h] Patients who survived severe illness from A(H7N9) virus infection had evidence of persistent lung damage and long-term pulmonary dysfunction.
[h=3]Funding[/h] National Science Fund for Distinguished Young Scholars (grant number 81525023); Program of Shanghai Academic/Technology Research Leader (grant number 18XD1400300); National Science and Technology Major Project of China (grant numbers 2017ZX10103009-005, 2018ZX10201001-010).
full article
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30026-2/fulltext