tetano
Editor, Senior Moderator
Lack of evidence for pre-symptomatic transmission of pandemic influenza virus A(H1N1) 2009 in an outbreak among teenagers; Germany, 2009
1. Julia Hermes1,2,
2. Helen Bernard1,
3. Udo Buchholz1,
4. Michaela Spackova1,3,
5. Johann L?w4,
6. Gunther Loytved4,
7. Thorsten Suess1,
8. Wolfgang Hautmann5,
9. Dirk Werber1
Article first published online: 18 APR 2011
DOI: 10.1111/j.1750-2659.2011.00251.x
? 2011 Blackwell Publishing Ltd
Please cite this paper as: Hermes et al. (2011) Lack of evidence for pre-symptomatic transmission of pandemic influenza virus A(H1N1) 2009 in an outbreak among teenagers; Germany, 2009. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2011.00251.x.
Background Observations on the role of pre-symptomatic transmission in the spread of influenza virus are scanty. In June 2009, an outbreak of pandemic A(H1N1) 2009 infection occurred at a teenager?s party in Germany. The objective of this study was to identify risk factors for pandemic A(H1N1) 2009 infection.
Methods We performed a retrospective cohort study among party guests. A case was defined as pandemic A(H1N1) 2009 infection confirmed by rRT-PCR who developed influenza-like illness between 1 and 5 June 2009. Contact patterns among party guests were evaluated.
Results In eight (36%) of 27 party guests, the outcome was ascertained. A travel returnee from a country with endemic pandemic A(H1N1) 2009 who fell ill toward the end of the party was identified as the source case. Party guests with pandemic A(H1N1) 2009 infection had talked significantly longer to the source case than non-infected persons (P-value: 0?001). Importantly, none (0/9) of those who had left the party prior to the source case?s symptom onset became infected compared to 7 (41%) of 17 who stayed overnight (P = 0?06), and these persons all had transmission-prone contacts to the source case.
Conclusions In this outbreak with one index case, there was no evidence to support pre-symptomatic transmission of pandemic A(H1N1) 2009. Further evidence is required, ideally from larger studies with multiple index cases, to more accurately characterize the potential for pre-symptomatic transmission of influenza virus.
http://onlinelibrary.wiley.com/doi/10.1111/j.1750-2659.2011.00251.x/abstract
1. Julia Hermes1,2,
2. Helen Bernard1,
3. Udo Buchholz1,
4. Michaela Spackova1,3,
5. Johann L?w4,
6. Gunther Loytved4,
7. Thorsten Suess1,
8. Wolfgang Hautmann5,
9. Dirk Werber1
Article first published online: 18 APR 2011
DOI: 10.1111/j.1750-2659.2011.00251.x
? 2011 Blackwell Publishing Ltd
Please cite this paper as: Hermes et al. (2011) Lack of evidence for pre-symptomatic transmission of pandemic influenza virus A(H1N1) 2009 in an outbreak among teenagers; Germany, 2009. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2011.00251.x.
Background Observations on the role of pre-symptomatic transmission in the spread of influenza virus are scanty. In June 2009, an outbreak of pandemic A(H1N1) 2009 infection occurred at a teenager?s party in Germany. The objective of this study was to identify risk factors for pandemic A(H1N1) 2009 infection.
Methods We performed a retrospective cohort study among party guests. A case was defined as pandemic A(H1N1) 2009 infection confirmed by rRT-PCR who developed influenza-like illness between 1 and 5 June 2009. Contact patterns among party guests were evaluated.
Results In eight (36%) of 27 party guests, the outcome was ascertained. A travel returnee from a country with endemic pandemic A(H1N1) 2009 who fell ill toward the end of the party was identified as the source case. Party guests with pandemic A(H1N1) 2009 infection had talked significantly longer to the source case than non-infected persons (P-value: 0?001). Importantly, none (0/9) of those who had left the party prior to the source case?s symptom onset became infected compared to 7 (41%) of 17 who stayed overnight (P = 0?06), and these persons all had transmission-prone contacts to the source case.
Conclusions In this outbreak with one index case, there was no evidence to support pre-symptomatic transmission of pandemic A(H1N1) 2009. Further evidence is required, ideally from larger studies with multiple index cases, to more accurately characterize the potential for pre-symptomatic transmission of influenza virus.
http://onlinelibrary.wiley.com/doi/10.1111/j.1750-2659.2011.00251.x/abstract