tetano
Editor, Senior Moderator
Published ahead of print 31 July 2013, doi: 10.1128/JVI.01724-13 JVI.01724-13
A Novel HA-F Protein Subunit Vaccine against Influenza and Respiratory Syncytial Virus
Tiffany M. Turner*,
Les P. Jones*,
S. Mark Tompkins* and
Ralph A. Tripp*#
+ Author Affiliations
* Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602
ABSTRACT
Influenza A virus and respiratory syncytial virus (RSV) cause substantial morbidity and mortality afflicting the ends of the age spectrum during the autumn through winter months in the United States. The benefit of vaccination against RSV and influenza using a subunit vaccine to enhance immunity and neutralizing antibody was investigated. Influenza hemagglutinin (HA) and RSV fusion (F) protein were tested as vaccine components alone and in combination to explore the adjuvant properties of RSV F protein on HA immunity. Mice vaccinated with HA and F exhibited robust immunity that when challenged had reduced viral burden for both influenza and RSV. These studies show an enhancing and cross-protective benefit of F protein for anti-HA immunity.
http://jvi.asm.org/content/early/2013/07/24/JVI.01724-13.abstract
A Novel HA-F Protein Subunit Vaccine against Influenza and Respiratory Syncytial Virus
Tiffany M. Turner*,
Les P. Jones*,
S. Mark Tompkins* and
Ralph A. Tripp*#
+ Author Affiliations
* Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602
ABSTRACT
Influenza A virus and respiratory syncytial virus (RSV) cause substantial morbidity and mortality afflicting the ends of the age spectrum during the autumn through winter months in the United States. The benefit of vaccination against RSV and influenza using a subunit vaccine to enhance immunity and neutralizing antibody was investigated. Influenza hemagglutinin (HA) and RSV fusion (F) protein were tested as vaccine components alone and in combination to explore the adjuvant properties of RSV F protein on HA immunity. Mice vaccinated with HA and F exhibited robust immunity that when challenged had reduced viral burden for both influenza and RSV. These studies show an enhancing and cross-protective benefit of F protein for anti-HA immunity.
http://jvi.asm.org/content/early/2013/07/24/JVI.01724-13.abstract