tetano
Editor, Senior Moderator
Jpn J Infect Dis
. 2021 Nov 30.
doi: 10.7883/yoken.JJID.2021.745. Online ahead of print.
Influenza A virus infection in domestic ferrets
Yudai Kuroda[SUP] 1 2 [/SUP], Ai Okada[SUP] 1 [/SUP], Hiroshi Shimoda[SUP] 1 [/SUP], Yasutsugu Miwa[SUP] 3 4 [/SUP], Akiko Watamori[SUP] 3 [/SUP], Hiroho Ishida[SUP] 4 [/SUP], Shin Murakami[SUP] 4 [/SUP], Ayato Takada[SUP] 5 [/SUP], Taisuke Horimoto[SUP] 4 [/SUP], Ken Maeda[SUP] 1 2 [/SUP]
Affiliations
Abstract
Ferrets are animals that are known to be susceptible to influenza A virus (IAV) infection. To evaluate the risk of IAV transmission from diseased ferrets to humans, we performed a serosurvey to detect specific antibodies against the H1, H3, H5, and H7 subtypes of IAV. We found a high positive rate of the H1 (24.1%) and H3 (5.2%) subtypes in pet ferrets by using an enzyme-linked immunosorbent assay for hemagglutinin proteins. The results were confirmed by the virus-neutralization test for representative antibody-positive serum samples. We also detected hemagglutinin and neuraminidase genes in two ferrets showing acute respiratory illness and whose owner was diagnosed with IAV infection; a human H1N1pdm virus was isolated from one of these ferrets. Our findings suggest that attention should be paid for IAV infection from humans to ferrets, and vice versa.
Keywords: Ferret; Influenza; Reverse zoonosis; Seroprevalence.
. 2021 Nov 30.
doi: 10.7883/yoken.JJID.2021.745. Online ahead of print.
Influenza A virus infection in domestic ferrets
Yudai Kuroda[SUP] 1 2 [/SUP], Ai Okada[SUP] 1 [/SUP], Hiroshi Shimoda[SUP] 1 [/SUP], Yasutsugu Miwa[SUP] 3 4 [/SUP], Akiko Watamori[SUP] 3 [/SUP], Hiroho Ishida[SUP] 4 [/SUP], Shin Murakami[SUP] 4 [/SUP], Ayato Takada[SUP] 5 [/SUP], Taisuke Horimoto[SUP] 4 [/SUP], Ken Maeda[SUP] 1 2 [/SUP]
Affiliations
- PMID: 34853194
- DOI: 10.7883/yoken.JJID.2021.745
Abstract
Ferrets are animals that are known to be susceptible to influenza A virus (IAV) infection. To evaluate the risk of IAV transmission from diseased ferrets to humans, we performed a serosurvey to detect specific antibodies against the H1, H3, H5, and H7 subtypes of IAV. We found a high positive rate of the H1 (24.1%) and H3 (5.2%) subtypes in pet ferrets by using an enzyme-linked immunosorbent assay for hemagglutinin proteins. The results were confirmed by the virus-neutralization test for representative antibody-positive serum samples. We also detected hemagglutinin and neuraminidase genes in two ferrets showing acute respiratory illness and whose owner was diagnosed with IAV infection; a human H1N1pdm virus was isolated from one of these ferrets. Our findings suggest that attention should be paid for IAV infection from humans to ferrets, and vice versa.
Keywords: Ferret; Influenza; Reverse zoonosis; Seroprevalence.