tetano
Editor, Senior Moderator
JGH Open
. 2025 Jul 11;9(7):e70220.
doi: 10.1002/jgh3.70220. eCollection 2025 Jul. Impact of COVID-19 on Venous Thromboembolism in Inflammatory Bowel Disease Hospitalizations: A Propensity-Matched Analysis
Mihir Prakash Shah[SUP] 1 [/SUP], Dushyant Singh Dahiya[SUP] 2 [/SUP], Pius Ojemolon[SUP] 3 [/SUP], Charmy Parikh[SUP] 4 [/SUP], Yash Shah[SUP] 5 [/SUP], Bhanu Siva Mohan Pinnam[SUP] 6 [/SUP], Manesh Kumar Gangwani[SUP] 7 [/SUP], Hassam Ali[SUP] 8 [/SUP], Chun-Wei Pan[SUP] 6 [/SUP], Ruchir Paladiya[SUP] 9 [/SUP], Abdul Mohammed[SUP] 10 [/SUP], Saurabh Chandan[SUP] 11 12 [/SUP], Benjamin Mba[SUP] 13 [/SUP], Babu P Mohan[SUP] 14 [/SUP]
Affiliations
Background and aim: Patients diagnosed with Inflammatory bowel disease (IBD) face a notably higher risk of venous thromboembolism (VTE), leading to significant health challenges. Similarly, coronavirus disease 2019 (COVID-19) is associated with an increased susceptibility to thrombosis. We aimed to assess the impact of COVID-19 on the risk of developing VTE in patients with an underlying diagnosis of IBD.
Methods: We retrospectively analyzed the National Inpatient Sample (NIS) 2020-21 to identify adult patients with IBD admitted with or without a principal diagnosis of COVID-19. We divided these patients into three groups (without COVID-19, with uncomplicated COVID-19, and with complicated COVID-19). Hospitalization characteristics, in-hospital mortality, odds of VTE, healthcare burden, and complications were compared.
Results: IBD patients with complicated COVID-19 infection had significantly higher odds of VTE (OR 5.60, 95% C.I. 3.63-8.65, p 0.001), an increase in odds of mortality (OR 29.13, 95% C.I. 22.59-37.57, p 0.001), higher healthcare resource utilization (including length of stay and total hospitalization charges), and worse secondary outcomes (like acute kidney injury and pancytopenia), compared to IBD patients without COVID-19. IBD patients with uncomplicated COVID-19 also had higher odds of VTE (OR 1.81, 95% C.I. 1.39-2.36, p 0.001) than those without COVID-19; however, there was no difference in mortality or length of stay between these two groups, and those with uncomplicated COVID-19 had lower average total hospitalization charges.
Conclusion: Patients with both complicated and uncomplicated COVID-19 were associated with higher odds of VTE compared to those without COVID-19. Patients with complicated COVID-19, in addition, also had higher odds of mortality.
Keywords: COVID‐19; NIS; inflammatory bowel disease; venous thromboembolism.
. 2025 Jul 11;9(7):e70220.
doi: 10.1002/jgh3.70220. eCollection 2025 Jul. Impact of COVID-19 on Venous Thromboembolism in Inflammatory Bowel Disease Hospitalizations: A Propensity-Matched Analysis
Mihir Prakash Shah[SUP] 1 [/SUP], Dushyant Singh Dahiya[SUP] 2 [/SUP], Pius Ojemolon[SUP] 3 [/SUP], Charmy Parikh[SUP] 4 [/SUP], Yash Shah[SUP] 5 [/SUP], Bhanu Siva Mohan Pinnam[SUP] 6 [/SUP], Manesh Kumar Gangwani[SUP] 7 [/SUP], Hassam Ali[SUP] 8 [/SUP], Chun-Wei Pan[SUP] 6 [/SUP], Ruchir Paladiya[SUP] 9 [/SUP], Abdul Mohammed[SUP] 10 [/SUP], Saurabh Chandan[SUP] 11 12 [/SUP], Benjamin Mba[SUP] 13 [/SUP], Babu P Mohan[SUP] 14 [/SUP]
Affiliations
- PMID: 40657470
- PMCID: PMC12247105
- DOI: 10.1002/jgh3.70220
Background and aim: Patients diagnosed with Inflammatory bowel disease (IBD) face a notably higher risk of venous thromboembolism (VTE), leading to significant health challenges. Similarly, coronavirus disease 2019 (COVID-19) is associated with an increased susceptibility to thrombosis. We aimed to assess the impact of COVID-19 on the risk of developing VTE in patients with an underlying diagnosis of IBD.
Methods: We retrospectively analyzed the National Inpatient Sample (NIS) 2020-21 to identify adult patients with IBD admitted with or without a principal diagnosis of COVID-19. We divided these patients into three groups (without COVID-19, with uncomplicated COVID-19, and with complicated COVID-19). Hospitalization characteristics, in-hospital mortality, odds of VTE, healthcare burden, and complications were compared.
Results: IBD patients with complicated COVID-19 infection had significantly higher odds of VTE (OR 5.60, 95% C.I. 3.63-8.65, p 0.001), an increase in odds of mortality (OR 29.13, 95% C.I. 22.59-37.57, p 0.001), higher healthcare resource utilization (including length of stay and total hospitalization charges), and worse secondary outcomes (like acute kidney injury and pancytopenia), compared to IBD patients without COVID-19. IBD patients with uncomplicated COVID-19 also had higher odds of VTE (OR 1.81, 95% C.I. 1.39-2.36, p 0.001) than those without COVID-19; however, there was no difference in mortality or length of stay between these two groups, and those with uncomplicated COVID-19 had lower average total hospitalization charges.
Conclusion: Patients with both complicated and uncomplicated COVID-19 were associated with higher odds of VTE compared to those without COVID-19. Patients with complicated COVID-19, in addition, also had higher odds of mortality.
Keywords: COVID‐19; NIS; inflammatory bowel disease; venous thromboembolism.