tetano
Editor, Senior Moderator
JGH Open
. 2024 Aug 8;8(8):e70004.
doi: 10.1002/jgh3.70004. eCollection 2024 Aug. Comparison of liver fibrosis scores and fatty liver on computed tomography as risk factors for severity of COVID-19
Yuji Kamiya[SUP] 1 [/SUP], Masahiro Shinoda[SUP] 2 [/SUP], Naoki Ishii[SUP] 3 [/SUP], Saki Yamamoto[SUP] 1 [/SUP], Tetsuo Sekine[SUP] 1 [/SUP], Miwa Morikawa[SUP] 2 [/SUP], Shinichiro Ota[SUP] 2 [/SUP], Mio Toyama-Kousaka[SUP] 2 [/SUP], Hidenori Takahashi[SUP] 2 [/SUP], Hiroaki Takei[SUP] 2 [/SUP], Masaharu Shinkai[SUP] 2 [/SUP]
Affiliations
Background and aim: Increased liver fibrosis scores (LFS), such as fibrosis-4 index (FIB-4) or non-alcoholic fatty liver disease fibrosis score (NFS), and fatty liver are known risk factors for severe coronavirus disease 2019 (COVID-19). The purpose of this study was to identify the best scores, which predict the prognosis of COVID-19.
Methods: Participants comprised consecutive Japanese COVID-19 patients admitted to our hospital between February 14, 2020, and April 14, 2021. Multivariate logistic regression analysis was performed to evaluate the relationships between LFS (FIB-4, NFS, aspartate aminotransferase-to-platelet ratio index [APRI], BARD score, and hepatic steatosis index [HSI]) or fatty liver on computed tomography (CT), and severity of COVID-19.
Results: Of the 415 patients (mean age, 59 years), 177 patients (42.7%) needed oxygen therapy, 90 patients (21.7%) worsened to severe COVID-19, and 45 patients (10.8%) died during admission. Multivariate logistic regression analysis showed that increased FIB-4 and NFS were risk factors for death, severe COVID-19, and oxygen demand; that increased BARD was a risk factor for severe COVID-19 and oxygen demand; and that increased APRI and HSI were not risk factors for any status of COVID-19. Furthermore, increased NFS or BARD and fatty liver were independent risk factors for severe COVID-19 and oxygen demand.
Conclusions: This study showed that FIB-4 and NFS were the best liver fibrosis scores that predicted worse prognosis for COVID-19, and that increased NFS or BARD and fatty liver evident on CT represented independent risk factors for severe COVID-19 and oxygen demand.
Keywords: COVID‐19; fatty liver; liver fibrosis scores; risk factors.
. 2024 Aug 8;8(8):e70004.
doi: 10.1002/jgh3.70004. eCollection 2024 Aug. Comparison of liver fibrosis scores and fatty liver on computed tomography as risk factors for severity of COVID-19
Yuji Kamiya[SUP] 1 [/SUP], Masahiro Shinoda[SUP] 2 [/SUP], Naoki Ishii[SUP] 3 [/SUP], Saki Yamamoto[SUP] 1 [/SUP], Tetsuo Sekine[SUP] 1 [/SUP], Miwa Morikawa[SUP] 2 [/SUP], Shinichiro Ota[SUP] 2 [/SUP], Mio Toyama-Kousaka[SUP] 2 [/SUP], Hidenori Takahashi[SUP] 2 [/SUP], Hiroaki Takei[SUP] 2 [/SUP], Masaharu Shinkai[SUP] 2 [/SUP]
Affiliations
- PMID: 39130093
- PMCID: PMC11310555
- DOI: 10.1002/jgh3.70004
Background and aim: Increased liver fibrosis scores (LFS), such as fibrosis-4 index (FIB-4) or non-alcoholic fatty liver disease fibrosis score (NFS), and fatty liver are known risk factors for severe coronavirus disease 2019 (COVID-19). The purpose of this study was to identify the best scores, which predict the prognosis of COVID-19.
Methods: Participants comprised consecutive Japanese COVID-19 patients admitted to our hospital between February 14, 2020, and April 14, 2021. Multivariate logistic regression analysis was performed to evaluate the relationships between LFS (FIB-4, NFS, aspartate aminotransferase-to-platelet ratio index [APRI], BARD score, and hepatic steatosis index [HSI]) or fatty liver on computed tomography (CT), and severity of COVID-19.
Results: Of the 415 patients (mean age, 59 years), 177 patients (42.7%) needed oxygen therapy, 90 patients (21.7%) worsened to severe COVID-19, and 45 patients (10.8%) died during admission. Multivariate logistic regression analysis showed that increased FIB-4 and NFS were risk factors for death, severe COVID-19, and oxygen demand; that increased BARD was a risk factor for severe COVID-19 and oxygen demand; and that increased APRI and HSI were not risk factors for any status of COVID-19. Furthermore, increased NFS or BARD and fatty liver were independent risk factors for severe COVID-19 and oxygen demand.
Conclusions: This study showed that FIB-4 and NFS were the best liver fibrosis scores that predicted worse prognosis for COVID-19, and that increased NFS or BARD and fatty liver evident on CT represented independent risk factors for severe COVID-19 and oxygen demand.
Keywords: COVID‐19; fatty liver; liver fibrosis scores; risk factors.