Mary Wilson
Well-known member
Original Investigation Infectious Diseases
March 22, 2021
He S. Yang, PhD[SUP]1,2[/SUP]; Victoria Costa, MD[SUP]1,2[/SUP]; Sabrina E. Racine-Brzostek, MD[SUP]1,2[/SUP]; et al
JAMA Netw Open. 2021;4(3):e214302. doi:10.1001/jamanetworkopen.2021.4302
Key Points
Question Are the quantity and quality of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) different among children, adolescents, and young adults?
Findings In this cross-sectional study evaluating 31?426 SARS-CoV-2 antibody tests performed between April 9 and August 31, 2020, immunoglobin G levels were found to vary in different age groups, despite similar seroprevalence in the pediatric and adult patient populations. SARS-CoV-2 immunoglobin G and total antibody levels, neutralizing activity, and avidity exhibited negative correlations with age in patients aged 1 to 24 years.
Meaning This analysis revealed distinct antibody responses in different age groups, suggesting that age-targeted strategies for disease screening and management as well as vaccine development may be warranted.
Abstract
Importance Accumulating evidence suggests that children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to manifest mild symptoms and are at a lower risk of developing severe respiratory disease compared with adults. It remains unknown how the immune response in children differs from that of adolescents and adults.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2777743
March 22, 2021
He S. Yang, PhD[SUP]1,2[/SUP]; Victoria Costa, MD[SUP]1,2[/SUP]; Sabrina E. Racine-Brzostek, MD[SUP]1,2[/SUP]; et al
JAMA Netw Open. 2021;4(3):e214302. doi:10.1001/jamanetworkopen.2021.4302
Key Points
Question Are the quantity and quality of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) different among children, adolescents, and young adults?
Findings In this cross-sectional study evaluating 31?426 SARS-CoV-2 antibody tests performed between April 9 and August 31, 2020, immunoglobin G levels were found to vary in different age groups, despite similar seroprevalence in the pediatric and adult patient populations. SARS-CoV-2 immunoglobin G and total antibody levels, neutralizing activity, and avidity exhibited negative correlations with age in patients aged 1 to 24 years.
Meaning This analysis revealed distinct antibody responses in different age groups, suggesting that age-targeted strategies for disease screening and management as well as vaccine development may be warranted.
Abstract
Importance Accumulating evidence suggests that children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to manifest mild symptoms and are at a lower risk of developing severe respiratory disease compared with adults. It remains unknown how the immune response in children differs from that of adolescents and adults.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2777743