Snowy Owl
Retired in 2010, In Memoriam
JAMA
[FONT=verdana, arial, helvetica, sans-serif] Avian Flu Clue
http://jama.ama-assn.org/cgi/content/extract/296/3/272-c
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[FONT=verdana, arial, helvetica, sans-serif] Avian Flu Clue
http://jama.ama-assn.org/cgi/content/extract/296/3/272-c
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[FONT=verdana, arial, helvetica, sans-serif][/FONT][FONT=verdana, arial, helvetica, sans-serif] Avian Flu Clue [/FONT] [FONT=verdana, arial, helvetica, sans-serif] <nobr>Joan Stephenson, PhD</nobr> [/FONT]
[FONT=verdana, arial, helvetica, sans-serif] JAMA. 2006;296:272.[/FONT]
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[FONT=verdana, arial, helvetica, sans-serif]Scientists from Hong Kong report new findings that support the<sup> </sup>hypothesis that some H5N1 avian influenza viruses are particularly<sup> </sup>deadly to humans because they can trigger a "cytokine storm"<sup> </sup>that causes the immune system to overreact (Zhou J et al. J<sup> </sup>Infect Dis. 2006;194:61-70).[/FONT]
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[FONT=verdana, arial, helvetica, sans-serif]The researchers infected cultured human immune cells (monocyte-derived<sup> </sup>macrophages [MDMs]) with human influenza virus or with the H5N1<sup> </sup>strain that caused a deadly 1997 outbreak in Hong Kong. They<sup> </sup>found that the H5N1-infected MDMs produced much higher levels<sup> </sup>of chemokines, a type of cytokine that directs white blood cells<sup> </sup>to inflammation sites. In addition, levels of chemokines and<sup> </sup>chemokine receptors were higher in MDMs from adults than in<sup> </sup>MDMs from newborns, suggesting that chemokines might be a key<sup> </sup>to the 1997 outbreak's higher mortality rate among adults.<sup> </sup>[/FONT]
[FONT=verdana, arial, helvetica, sans-serif]Scientists have suggested that a cytokine storm played a role<sup> </sup>in the virulence of the <nobr>. . .</nobr> [Full Text of this Article][/FONT]
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[FONT=verdana, arial, helvetica, sans-serif] JAMA. 2006;296:272.[/FONT]
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<table align="center" border="0" cellpadding="0" cellspacing="0" width="70%"> <tbody><tr><td colspan="3" bgcolor="#6a90aa">
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[FONT=verdana, arial, helvetica, sans-serif]Scientists from Hong Kong report new findings that support the<sup> </sup>hypothesis that some H5N1 avian influenza viruses are particularly<sup> </sup>deadly to humans because they can trigger a "cytokine storm"<sup> </sup>that causes the immune system to overreact (Zhou J et al. J<sup> </sup>Infect Dis. 2006;194:61-70).[/FONT]
[FONT=verdana, arial, helvetica, sans-serif]
<sup> </sup>[/FONT]
[FONT=verdana, arial, helvetica, sans-serif]The researchers infected cultured human immune cells (monocyte-derived<sup> </sup>macrophages [MDMs]) with human influenza virus or with the H5N1<sup> </sup>strain that caused a deadly 1997 outbreak in Hong Kong. They<sup> </sup>found that the H5N1-infected MDMs produced much higher levels<sup> </sup>of chemokines, a type of cytokine that directs white blood cells<sup> </sup>to inflammation sites. In addition, levels of chemokines and<sup> </sup>chemokine receptors were higher in MDMs from adults than in<sup> </sup>MDMs from newborns, suggesting that chemokines might be a key<sup> </sup>to the 1997 outbreak's higher mortality rate among adults.<sup> </sup>[/FONT]
[FONT=verdana, arial, helvetica, sans-serif]Scientists have suggested that a cytokine storm played a role<sup> </sup>in the virulence of the <nobr>. . .</nobr> [Full Text of this Article][/FONT]
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