Giuseppe
Emeritus
[Source: US National Library of Medicine, full text: (LINK). Abstract, edited.]
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J Virol. 2013 Mar 27. [Epub ahead of print]
Substitutions T200A and E227A in the hemagglutinin of pandemic 2009 influenza A virus increase lethality but decrease transmission.
Mart?nez-Romero C, de Vries E, Belicha-Villanueva A, Mena I, Tscherne DM, Gillespie VL, Albrecht RA, de Haan CA, Garc?a-Sastre A.
Source: Department of Microbiology.
Abstract
We describe that swine influenza virus-like substitutions T200A and E227A in the hemagglutinin of the 2009 pandemic influenza virus alter its pathogenesis and transmission. Viral replication is increased in mammalian cells. Infected mice show increased disease as measured by weight loss and lethality. Transmission in ferrets is decreased in the presence of both substitutions, suggesting that 200T and 227E HA amino acids are adaptive changes in the HA of swine-origin influenza viruses associated with increased transmission and decreased pathogenesis.
PMID: 23536663 [PubMed - as supplied by publisher]
-Substitutions T200A and E227A in the hemagglutinin of pandemic 2009 influenza A virus increase lethality but decrease transmission.
Mart?nez-Romero C, de Vries E, Belicha-Villanueva A, Mena I, Tscherne DM, Gillespie VL, Albrecht RA, de Haan CA, Garc?a-Sastre A.
Source: Department of Microbiology.
Abstract
We describe that swine influenza virus-like substitutions T200A and E227A in the hemagglutinin of the 2009 pandemic influenza virus alter its pathogenesis and transmission. Viral replication is increased in mammalian cells. Infected mice show increased disease as measured by weight loss and lethality. Transmission in ferrets is decreased in the presence of both substitutions, suggesting that 200T and 227E HA amino acids are adaptive changes in the HA of swine-origin influenza viruses associated with increased transmission and decreased pathogenesis.
PMID: 23536663 [PubMed - as supplied by publisher]
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