tetano
Editor, Senior Moderator
J Thromb Thrombolysis
. 2021 Apr 12.
doi: 10.1007/s11239-021-02444-0. Online ahead of print.
Abnormal immunothrombosis and lupus anticoagulant in a catastrophic COVID-19 recalling Asherson's syndrome
Luca Roncati[SUP] 1 [/SUP], Lorenzo Corsi[SUP] 2 [/SUP], Giuseppe Barbolini[SUP] 3 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) is a complex disease with many clinicopathological aspects, including abnormal immunothrombosis, and the full comprehension of its pathogenetic mechanisms is urgently required.
Methods/results: By means of a multidisciplinary approach, we here report a catastrophic COVID-19 in a 44-year-old Philippine male patient, discovered lupus anticoagulant (LAC)-positive shortly before death, occurred 8 days after hospitalization in a clinical scenario refractory to standard high acuity care recalling Asherson's syndrome (catastrophic antiphospholipid syndrome).
Conclusion: A parallelism between this severe form of COVID-19 and Asherson's syndrome can be so drawn. Both the diseases in fact exhibit hypercytokinemia, thrombotic microangiopathy, disseminated intravascular coagulation and multiple organ failure, they show a relationship with viral infections, and they are burdened by a high mortality rate. A genetic predisposition to develop these two overlapping conditions may be supposed.
Keywords: Abnormal immunothrombosis; Antiphospholipid syndrome (Hughes syndrome); Asherson?s syndrome; Coronavirus disease 2019 (COVID-19); Lupus anticoagulant (LAC); Megakaryocytes.
. 2021 Apr 12.
doi: 10.1007/s11239-021-02444-0. Online ahead of print.
Abnormal immunothrombosis and lupus anticoagulant in a catastrophic COVID-19 recalling Asherson's syndrome
Luca Roncati[SUP] 1 [/SUP], Lorenzo Corsi[SUP] 2 [/SUP], Giuseppe Barbolini[SUP] 3 [/SUP]
Affiliations
- PMID: 33844151
- DOI: 10.1007/s11239-021-02444-0
Abstract
Background: Coronavirus disease 2019 (COVID-19) is a complex disease with many clinicopathological aspects, including abnormal immunothrombosis, and the full comprehension of its pathogenetic mechanisms is urgently required.
Methods/results: By means of a multidisciplinary approach, we here report a catastrophic COVID-19 in a 44-year-old Philippine male patient, discovered lupus anticoagulant (LAC)-positive shortly before death, occurred 8 days after hospitalization in a clinical scenario refractory to standard high acuity care recalling Asherson's syndrome (catastrophic antiphospholipid syndrome).
Conclusion: A parallelism between this severe form of COVID-19 and Asherson's syndrome can be so drawn. Both the diseases in fact exhibit hypercytokinemia, thrombotic microangiopathy, disseminated intravascular coagulation and multiple organ failure, they show a relationship with viral infections, and they are burdened by a high mortality rate. A genetic predisposition to develop these two overlapping conditions may be supposed.
Keywords: Abnormal immunothrombosis; Antiphospholipid syndrome (Hughes syndrome); Asherson?s syndrome; Coronavirus disease 2019 (COVID-19); Lupus anticoagulant (LAC); Megakaryocytes.