tetano
Editor, Senior Moderator
J Public Health (Oxf)
. 2020 Jun 3;fdaa074.
doi: 10.1093/pubmed/fdaa074. Online ahead of print.
HyPE Study: Hydroxychloroquine Prophylaxis-Related Adverse Events' Analysis Among Healthcare Workers During COVID-19 Pandemic: A Rising Public Health Concern
Bada Sharanappa Nagaraja[SUP] 1 [/SUP], Kalhalli Narayanaswamy Ramesh[SUP] 1 [/SUP], Debjyoti Dhar[SUP] 2 3 [/SUP], Mahammad Samim Mondal[SUP] 2 3 [/SUP], Treshita Dey[SUP] 4 [/SUP], Subhrakamal Saha[SUP] 5 [/SUP], Mumtaz Ali Khan[SUP] 1 [/SUP], Shah Dhiren Rutul[SUP] 2 [/SUP], Kishore Pratik[SUP] 2 [/SUP], Jayaram Manjula[SUP] 3 [/SUP], Thuppanattumadam Ananthasubramanian Sangeeth[SUP] 2 3 [/SUP], Vikram Singh[SUP] 2 3 [/SUP]
Affiliations
Abstract
Background: The rising burden of Coronavirus disease (COVID-19) has led to the mass use of hydroxychloroquine by healthcare workers (HCWs). Adverse event profile of this drug when used as prophylaxis is not well known in the literature.
Methods: A retrospective, cross-sectional study was conducted across the country using semi-structured web-based questionnaire among COVID-19 negative and asymptomatic healthcare workers, taking hydroxychloroquine prophylaxis. Descriptive and multivariate logistic-regression models were applied for analysis.
Results: Of the 166 participants, at least one adverse event was experienced by 37.9% participants, gastrointestinal being the most common (30.7%). Risk was higher in participants <40 years age (odd's ratio (OR): 2.44, 95% confidence interval (CI): 1.18-5.05) and after first dose of hydroxychloroquine (51.2%, OR: 2.38, 95%CI: 1.17-4.84). Hydroxychloroquine prophylaxis was initiated without electrocardiography by 80.1% of HCWs. Only 21.6% of those with cardiovascular disease could get prior ECG.
Conclusions: A higher incidence of adverse events was observed when results were compared with studies involving patients on long-term hydroxychloroquine therapy. Younger age and first dose were associated with greater incidence of adverse events though all were self-limiting. Monitoring prior and during prophylaxis was inadequate even among those with cardiovascular disease and risk-factors. However, no serious cardiovascular events were reported.
Keywords: COVID-19; adverse effects; hydroxychloroquine; prophylaxis.
. 2020 Jun 3;fdaa074.
doi: 10.1093/pubmed/fdaa074. Online ahead of print.
HyPE Study: Hydroxychloroquine Prophylaxis-Related Adverse Events' Analysis Among Healthcare Workers During COVID-19 Pandemic: A Rising Public Health Concern
Bada Sharanappa Nagaraja[SUP] 1 [/SUP], Kalhalli Narayanaswamy Ramesh[SUP] 1 [/SUP], Debjyoti Dhar[SUP] 2 3 [/SUP], Mahammad Samim Mondal[SUP] 2 3 [/SUP], Treshita Dey[SUP] 4 [/SUP], Subhrakamal Saha[SUP] 5 [/SUP], Mumtaz Ali Khan[SUP] 1 [/SUP], Shah Dhiren Rutul[SUP] 2 [/SUP], Kishore Pratik[SUP] 2 [/SUP], Jayaram Manjula[SUP] 3 [/SUP], Thuppanattumadam Ananthasubramanian Sangeeth[SUP] 2 3 [/SUP], Vikram Singh[SUP] 2 3 [/SUP]
Affiliations
- PMID: 32490532
- DOI: 10.1093/pubmed/fdaa074
Abstract
Background: The rising burden of Coronavirus disease (COVID-19) has led to the mass use of hydroxychloroquine by healthcare workers (HCWs). Adverse event profile of this drug when used as prophylaxis is not well known in the literature.
Methods: A retrospective, cross-sectional study was conducted across the country using semi-structured web-based questionnaire among COVID-19 negative and asymptomatic healthcare workers, taking hydroxychloroquine prophylaxis. Descriptive and multivariate logistic-regression models were applied for analysis.
Results: Of the 166 participants, at least one adverse event was experienced by 37.9% participants, gastrointestinal being the most common (30.7%). Risk was higher in participants <40 years age (odd's ratio (OR): 2.44, 95% confidence interval (CI): 1.18-5.05) and after first dose of hydroxychloroquine (51.2%, OR: 2.38, 95%CI: 1.17-4.84). Hydroxychloroquine prophylaxis was initiated without electrocardiography by 80.1% of HCWs. Only 21.6% of those with cardiovascular disease could get prior ECG.
Conclusions: A higher incidence of adverse events was observed when results were compared with studies involving patients on long-term hydroxychloroquine therapy. Younger age and first dose were associated with greater incidence of adverse events though all were self-limiting. Monitoring prior and during prophylaxis was inadequate even among those with cardiovascular disease and risk-factors. However, no serious cardiovascular events were reported.
Keywords: COVID-19; adverse effects; hydroxychloroquine; prophylaxis.