tetano
Editor, Senior Moderator
J Perinatol
. 2022 Aug 4.
doi: 10.1038/s41372-022-01467-6. Online ahead of print.
Preterm birth among pregnant persons with severe acute respiratory syndrome Coronavirus 2 infection
Suzanne M Newton[SUP] 1 [/SUP], Emily L Reeves[SUP] 2 [/SUP], Emily O'Malley Olsen[SUP] 2 [/SUP], Kate R Woodworth[SUP] 2 [/SUP], Sherry L Farr[SUP] 3 [/SUP], Romeo R Galang[SUP] 2 [/SUP], Megan R Reynolds[SUP] 2 [/SUP], Elizabeth Harvey[SUP] 4 5 [/SUP], Jing Shi[SUP] 6 [/SUP], Eirini Nestoridi[SUP] 7 [/SUP], Jerusha Barton[SUP] 8 [/SUP], Van P Ngo[SUP] 9 [/SUP], Mamie Lush[SUP] 10 [/SUP], Nicole D Longcore[SUP] 11 [/SUP], Paula Dzimira[SUP] 12 [/SUP], Lucille K Im[SUP] 13 [/SUP], Ayomide Sokale[SUP] 14 [/SUP], Samantha Siebman[SUP] 15 [/SUP], Camille Delgado López[SUP] 16 [/SUP], Tiffany Chen[SUP] 17 [/SUP], Evan L Mobley[SUP] 18 [/SUP], Salma Khuwaja[SUP] 19 [/SUP], Paul A Romitti[SUP] 20 [/SUP], Carolyn Fredette[SUP] 21 [/SUP], Esther M Ellis[SUP] 22 [/SUP], Kristin Silcox[SUP] 23 [/SUP], Aron J Hall[SUP] 2 [/SUP], Eduardo Azziz-Baumgartner[SUP] 2 [/SUP], Suzanne M Gilboa[SUP] 2 [/SUP], Carrie K Shapiro-Mendoza[SUP] 5 [/SUP], Van T Tong[SUP] 2 [/SUP]
Affiliations
Abstract
Objective: We examined the relationship between trimester of SARS-CoV-2 infection, illness severity, and risk for preterm birth.
Study design: We analyzed data for 6336 pregnant persons with SARS-CoV-2 infection in 2020 in the United States. Risk ratios for preterm birth were calculated for illness severity, trimester of infection, and illness severity stratified by trimester of infection adjusted for age, selected underlying medical conditions, and pregnancy complications.
Result: Pregnant persons with critical COVID-19 or asymptomatic infection, compared to mild COVID-19, in the second or third trimester were at increased risk of preterm birth. Pregnant persons with moderate-to-severe COVID-19 did not show increased risk of preterm birth in any trimester.
Conclusion: Critical COVID-19 in the second or third trimester was associated with increased risk of preterm birth. This finding can be used to guide prevention strategies, including vaccination, and inform clinical practices for pregnant persons.
. 2022 Aug 4.
doi: 10.1038/s41372-022-01467-6. Online ahead of print.
Preterm birth among pregnant persons with severe acute respiratory syndrome Coronavirus 2 infection
Suzanne M Newton[SUP] 1 [/SUP], Emily L Reeves[SUP] 2 [/SUP], Emily O'Malley Olsen[SUP] 2 [/SUP], Kate R Woodworth[SUP] 2 [/SUP], Sherry L Farr[SUP] 3 [/SUP], Romeo R Galang[SUP] 2 [/SUP], Megan R Reynolds[SUP] 2 [/SUP], Elizabeth Harvey[SUP] 4 5 [/SUP], Jing Shi[SUP] 6 [/SUP], Eirini Nestoridi[SUP] 7 [/SUP], Jerusha Barton[SUP] 8 [/SUP], Van P Ngo[SUP] 9 [/SUP], Mamie Lush[SUP] 10 [/SUP], Nicole D Longcore[SUP] 11 [/SUP], Paula Dzimira[SUP] 12 [/SUP], Lucille K Im[SUP] 13 [/SUP], Ayomide Sokale[SUP] 14 [/SUP], Samantha Siebman[SUP] 15 [/SUP], Camille Delgado López[SUP] 16 [/SUP], Tiffany Chen[SUP] 17 [/SUP], Evan L Mobley[SUP] 18 [/SUP], Salma Khuwaja[SUP] 19 [/SUP], Paul A Romitti[SUP] 20 [/SUP], Carolyn Fredette[SUP] 21 [/SUP], Esther M Ellis[SUP] 22 [/SUP], Kristin Silcox[SUP] 23 [/SUP], Aron J Hall[SUP] 2 [/SUP], Eduardo Azziz-Baumgartner[SUP] 2 [/SUP], Suzanne M Gilboa[SUP] 2 [/SUP], Carrie K Shapiro-Mendoza[SUP] 5 [/SUP], Van T Tong[SUP] 2 [/SUP]
Affiliations
- PMID: 35927486
- DOI: 10.1038/s41372-022-01467-6
Abstract
Objective: We examined the relationship between trimester of SARS-CoV-2 infection, illness severity, and risk for preterm birth.
Study design: We analyzed data for 6336 pregnant persons with SARS-CoV-2 infection in 2020 in the United States. Risk ratios for preterm birth were calculated for illness severity, trimester of infection, and illness severity stratified by trimester of infection adjusted for age, selected underlying medical conditions, and pregnancy complications.
Result: Pregnant persons with critical COVID-19 or asymptomatic infection, compared to mild COVID-19, in the second or third trimester were at increased risk of preterm birth. Pregnant persons with moderate-to-severe COVID-19 did not show increased risk of preterm birth in any trimester.
Conclusion: Critical COVID-19 in the second or third trimester was associated with increased risk of preterm birth. This finding can be used to guide prevention strategies, including vaccination, and inform clinical practices for pregnant persons.