tetano
Editor, Senior Moderator
J Pediatr Endocrinol Metab
. 2020 Dec 11.
doi: 10.1515/jpem-2020-0503. Online ahead of print.
Transient benign hyperphosphatasemia due to COVID-19: the first case report
Tugba Erat[SUP] 1 [/SUP], M?ge Atar[SUP] 1 [/SUP], Tugba Kontbay[SUP] 1 [/SUP]
Affiliations
Abstract
Objectives: Coronavirus disease (COVID-19) rapidly spread worldwide in a few months and was declared as a worldwide pandemic by WHO in March 2020. Transient benign hyperphosphatasemia (THI) is a benign condition associated with marked elevation of alkaline phosphatase (ALP) without any other kidney, bone, and liver pathologies.
Case presentation: Herein, we report a previously healthy 16-month-old female patient who developed a secondary transient benign hyperphosphatasemia associated with SARS-CoV-2. Patient whole family's SARS-CoV-2 real-time reverse transcription-polymerase chain reaction (RT-PCR) results were positive. Since THI is a diagnosis of exclusion, other reasons that may cause ALP elevation should be ruled out. ALP activity decreased and turned to normal ranges within the following month. THI has been reported to be in association with various conditions. Its relationship with many viruses has been reported previously.
Conclusions: If ALP elevation is detected in patients with COVID 19 due to the increasing number of infections, THI should be considered if there is no other accompanying pathology.
Keywords: COVID-19; transient hyperphosphatasemia.
. 2020 Dec 11.
doi: 10.1515/jpem-2020-0503. Online ahead of print.
Transient benign hyperphosphatasemia due to COVID-19: the first case report
Tugba Erat[SUP] 1 [/SUP], M?ge Atar[SUP] 1 [/SUP], Tugba Kontbay[SUP] 1 [/SUP]
Affiliations
- PMID: 33577728
- DOI: 10.1515/jpem-2020-0503
Abstract
Objectives: Coronavirus disease (COVID-19) rapidly spread worldwide in a few months and was declared as a worldwide pandemic by WHO in March 2020. Transient benign hyperphosphatasemia (THI) is a benign condition associated with marked elevation of alkaline phosphatase (ALP) without any other kidney, bone, and liver pathologies.
Case presentation: Herein, we report a previously healthy 16-month-old female patient who developed a secondary transient benign hyperphosphatasemia associated with SARS-CoV-2. Patient whole family's SARS-CoV-2 real-time reverse transcription-polymerase chain reaction (RT-PCR) results were positive. Since THI is a diagnosis of exclusion, other reasons that may cause ALP elevation should be ruled out. ALP activity decreased and turned to normal ranges within the following month. THI has been reported to be in association with various conditions. Its relationship with many viruses has been reported previously.
Conclusions: If ALP elevation is detected in patients with COVID 19 due to the increasing number of infections, THI should be considered if there is no other accompanying pathology.
Keywords: COVID-19; transient hyperphosphatasemia.