tetano
Editor, Senior Moderator
J Pediatr
. 2020 Jun 18;S0022-3476(20)30743-5.
doi: 10.1016/j.jpeds.2020.06.041. Online ahead of print.
A Comparison Between Chinese Children Infected With COVID-19 and With SARS
Xiaoli Xiong[SUP] 1 [/SUP], Gilbert T Chua[SUP] 2 [/SUP], Shuiqing Chi[SUP] 3 [/SUP], Mike Yat Wah Kwan[SUP] 4 [/SUP], Wilfred Hing Sang Wong[SUP] 2 [/SUP], Aifen Zhou[SUP] 5 [/SUP], Chi Chiu Shek[SUP] 4 [/SUP], Keith Ts Tung[SUP] 2 [/SUP], Huan Qin[SUP] 6 [/SUP], Rosa S Wong[SUP] 2 [/SUP], Xue Li[SUP] 7 [/SUP], Peng Chen[SUP] 8 [/SUP], Shuai Li[SUP] 3 [/SUP], Celine S Chui[SUP] 7 [/SUP], Winnie Wy Tso[SUP] 2 [/SUP], Marco Hk Ho[SUP] 2 [/SUP], Ian Ck Wong[SUP] 9 [/SUP], Godfrey Cf Chan[SUP] 2 [/SUP], Yu Lung Lau[SUP] 2 [/SUP], Kenneth Ky Wong[SUP] 10 [/SUP], Patrick Hy Chung[SUP] 10 [/SUP], Hui Li[SUP] 11 [/SUP], Paul Kh Tam[SUP] 12 [/SUP], Shao-Tao Tang[SUP] 3 [/SUP], Patrick Lp[SUP] 13 [/SUP]
Affiliations
Abstract
Objectives: To compare the clinical and laboratory features of severe acute respiratory syndrome 2003 (SARS) and coronavirus disease 2019 (COVID-19) in two Chinese pediatric cohorts, given that the causative pathogens and are biologically similar.
, study design: This is a cross-sectional study reviewing paediatric patients with SARS (n = 43) and COVID-19 (n=244) who were admitted to the Princess Margaret Hospital in Hong Kong and Wuhan Children's Hospital in Wuhan, respectively. Demographics, hospital length of stay, clinical and laboratory features were compared RESULTS: Overall, 97.7% of patients with SARS and 85.2% of patients with COVID-19 had epidemiological associations with known cases. Significantly more patients with SARS developed fever, chills, myalgia, malaise, coryza, sore throat, sputum production, nausea, headache, and dizziness than patients COVID-19. No SARS patients were asymptomatic at the time of admission. 29.1% and 20.9% COVID-19 patients were asymptomatic on admission and throughout their hospital stay, respectively. More SARS patients required oxygen supplementation than COVID-19 patients (18.6 vs. 4.7%, P = 004). Only 1.6% COVID-19 and 2.3% SARS patients required mechanical ventilation. Leukopenia (37.2% vs. 18.6%, p=0.008), lymphopenia (95.4% versus 32.6%, p<0.01), and thrombocytopenia (41.9% vs 3.8%, p<0.001) were significantly more common in SARS than COVID-19 patients. The duration between positive and negative nasopharyngeal aspirate and the length in hospital stay were similar in COVID-19 patients regardless of whether they were asymptomatic or symptomatic, suggesting a similar duration of viral shedding.
Conclusions: Children with COVID-19 were less symptomatic and had more favorable hematological findings than children with SARS.
Keywords: COVID-19; Children; Chinese; SARS.
. 2020 Jun 18;S0022-3476(20)30743-5.
doi: 10.1016/j.jpeds.2020.06.041. Online ahead of print.
A Comparison Between Chinese Children Infected With COVID-19 and With SARS
Xiaoli Xiong[SUP] 1 [/SUP], Gilbert T Chua[SUP] 2 [/SUP], Shuiqing Chi[SUP] 3 [/SUP], Mike Yat Wah Kwan[SUP] 4 [/SUP], Wilfred Hing Sang Wong[SUP] 2 [/SUP], Aifen Zhou[SUP] 5 [/SUP], Chi Chiu Shek[SUP] 4 [/SUP], Keith Ts Tung[SUP] 2 [/SUP], Huan Qin[SUP] 6 [/SUP], Rosa S Wong[SUP] 2 [/SUP], Xue Li[SUP] 7 [/SUP], Peng Chen[SUP] 8 [/SUP], Shuai Li[SUP] 3 [/SUP], Celine S Chui[SUP] 7 [/SUP], Winnie Wy Tso[SUP] 2 [/SUP], Marco Hk Ho[SUP] 2 [/SUP], Ian Ck Wong[SUP] 9 [/SUP], Godfrey Cf Chan[SUP] 2 [/SUP], Yu Lung Lau[SUP] 2 [/SUP], Kenneth Ky Wong[SUP] 10 [/SUP], Patrick Hy Chung[SUP] 10 [/SUP], Hui Li[SUP] 11 [/SUP], Paul Kh Tam[SUP] 12 [/SUP], Shao-Tao Tang[SUP] 3 [/SUP], Patrick Lp[SUP] 13 [/SUP]
Affiliations
- PMID: 32565097
- DOI: 10.1016/j.jpeds.2020.06.041
Abstract
Objectives: To compare the clinical and laboratory features of severe acute respiratory syndrome 2003 (SARS) and coronavirus disease 2019 (COVID-19) in two Chinese pediatric cohorts, given that the causative pathogens and are biologically similar.
, study design: This is a cross-sectional study reviewing paediatric patients with SARS (n = 43) and COVID-19 (n=244) who were admitted to the Princess Margaret Hospital in Hong Kong and Wuhan Children's Hospital in Wuhan, respectively. Demographics, hospital length of stay, clinical and laboratory features were compared RESULTS: Overall, 97.7% of patients with SARS and 85.2% of patients with COVID-19 had epidemiological associations with known cases. Significantly more patients with SARS developed fever, chills, myalgia, malaise, coryza, sore throat, sputum production, nausea, headache, and dizziness than patients COVID-19. No SARS patients were asymptomatic at the time of admission. 29.1% and 20.9% COVID-19 patients were asymptomatic on admission and throughout their hospital stay, respectively. More SARS patients required oxygen supplementation than COVID-19 patients (18.6 vs. 4.7%, P = 004). Only 1.6% COVID-19 and 2.3% SARS patients required mechanical ventilation. Leukopenia (37.2% vs. 18.6%, p=0.008), lymphopenia (95.4% versus 32.6%, p<0.01), and thrombocytopenia (41.9% vs 3.8%, p<0.001) were significantly more common in SARS than COVID-19 patients. The duration between positive and negative nasopharyngeal aspirate and the length in hospital stay were similar in COVID-19 patients regardless of whether they were asymptomatic or symptomatic, suggesting a similar duration of viral shedding.
Conclusions: Children with COVID-19 were less symptomatic and had more favorable hematological findings than children with SARS.
Keywords: COVID-19; Children; Chinese; SARS.