tetano
Editor, Senior Moderator
J Paediatr Child Health
. 2025 Feb 11.
doi: 10.1111/jpc.70014. Online ahead of print. The Clinical Burden of SARS-CoV-2 Compared to Influenza A in the Same Cohort of Paediatric Outpatients; Increased Influenza Severity and Potential Insights
Papadopoulou Athina[SUP] 1 [/SUP], Lampidi Stavroula[SUP] 1 [/SUP], Mermiri T Despoina Zoe[SUP] 2 [/SUP], Kostaridou Stavroula[SUP] 2 [/SUP], Kanariou G Maria[SUP] 3 4 [/SUP]
Affiliations
Introduction: The variation in the clinical severity of viral infections remains a matter of scientific debate. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Influenza A virus (IAV) are both RNA viruses, exhibiting a range of clinical presentations, ranging from asymptomatic cases to fatalities, influenced by both viral and host factors. A descriptive real-life study was conducted, aiming to compare the clinical manifestations of recent COVID-19 with those of IAV infection in the same group of non-hospitalised, unvaccinated children.
Materials and method: Between September 2021 and February 2023, we evaluated 115 individuals (male 48.7%, mean age 101.8 ± 50.8 months) who had not received vaccination for both SARS-CoV-2 and the quadrivalent influenza vaccine and were documented to be infected with both viruses within a 12-month time interval. The visual analogue scale (VAS-5) was used to assess parents'/patients' evaluation comparing the two infections.
Results: In cases of IAV infection, a significantly higher prevalence of prolonged high fever, upper and lower respiratory symptoms, and secondary infections was observed. The majority (74.8%) of patients and/or parents assessed IAV as a more severe clinical syndrome compared with SARS-CoV-2.
Conclusions: The clinical burden of IAV was found to be greater than that of SARS-CoV-2 infection in the same unvaccinated children. This variation in clinical severity may provide a reference for effective vaccination policies; however, underlying mechanisms that could explain this difference require further evaluation.
Keywords: COVID‐19; SARS‐CoV‐2; children; clinical severity; influenza a.
. 2025 Feb 11.
doi: 10.1111/jpc.70014. Online ahead of print. The Clinical Burden of SARS-CoV-2 Compared to Influenza A in the Same Cohort of Paediatric Outpatients; Increased Influenza Severity and Potential Insights
Papadopoulou Athina[SUP] 1 [/SUP], Lampidi Stavroula[SUP] 1 [/SUP], Mermiri T Despoina Zoe[SUP] 2 [/SUP], Kostaridou Stavroula[SUP] 2 [/SUP], Kanariou G Maria[SUP] 3 4 [/SUP]
Affiliations
- PMID: 39935033
- DOI: 10.1111/jpc.70014
Introduction: The variation in the clinical severity of viral infections remains a matter of scientific debate. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Influenza A virus (IAV) are both RNA viruses, exhibiting a range of clinical presentations, ranging from asymptomatic cases to fatalities, influenced by both viral and host factors. A descriptive real-life study was conducted, aiming to compare the clinical manifestations of recent COVID-19 with those of IAV infection in the same group of non-hospitalised, unvaccinated children.
Materials and method: Between September 2021 and February 2023, we evaluated 115 individuals (male 48.7%, mean age 101.8 ± 50.8 months) who had not received vaccination for both SARS-CoV-2 and the quadrivalent influenza vaccine and were documented to be infected with both viruses within a 12-month time interval. The visual analogue scale (VAS-5) was used to assess parents'/patients' evaluation comparing the two infections.
Results: In cases of IAV infection, a significantly higher prevalence of prolonged high fever, upper and lower respiratory symptoms, and secondary infections was observed. The majority (74.8%) of patients and/or parents assessed IAV as a more severe clinical syndrome compared with SARS-CoV-2.
Conclusions: The clinical burden of IAV was found to be greater than that of SARS-CoV-2 infection in the same unvaccinated children. This variation in clinical severity may provide a reference for effective vaccination policies; however, underlying mechanisms that could explain this difference require further evaluation.
Keywords: COVID‐19; SARS‐CoV‐2; children; clinical severity; influenza a.