tetano
Editor, Senior Moderator
J Neurol
. 2025 Feb 11;272(3):197.
doi: 10.1007/s00415-024-12873-5. Differences in functional outcome of COVID-19 and non-COVID-19 patients with critical illness polyneuropathy/ myopathy: a multicenter cohort study
Michael Klein[SUP] #[/SUP][SUP] 1 [/SUP], Bernadette Einhäupl[SUP] #[/SUP][SUP] 2 [/SUP], Eva Grill[SUP] 1 3 [/SUP], Gergana Drunin[SUP] 4 [/SUP], Simone Schmidt[SUP] 5 [/SUP], Cay Cordes[SUP] 6 [/SUP], Marion Egger[SUP] 1 7 [/SUP], Hans-Jürgen Gdynia[SUP] 8 [/SUP], Anna Gorsler[SUP] 9 [/SUP], Danae Götze[SUP] 10 [/SUP], Jens Dieter Rollnik[SUP] 5 [/SUP], Martin Justinus Rosenfelder[SUP] 10 11 12 [/SUP], Ernst Walther[SUP] 13 [/SUP], Daniel Wertheimer[SUP] 14 [/SUP], Corinna Wimmer[SUP] 10 7 [/SUP], Peter Young[SUP] 15 [/SUP], Klaus Jahn[SUP] #[/SUP][SUP] 3 7 [/SUP], Andreas Bender[SUP] #[/SUP][SUP] 10 11 16 [/SUP]
Affiliations
Background: Up to 80% of intensive care unit (ICU) patients suffer from neuromuscular disorders like critical illness polyneuropathy/myopathy (CIP/CIM), requiring further rehabilitation.
Objective: This study investigates differences in the clinical course between Coronavirus Disease 2019 (COVID-19) and non-COVID-19 patients with CIP/CIM undergoing post-acute neurological rehabilitation (PANR) and the impact of COVID-19 on rehabilitation outcomes.
Methods: A multicenter observational study was conducted in nine German PANR facilities. The clinical course and outcome were compared between COVID-19 and non-COVID-19 patients at rehabilitation admission and discharge. Functional outcomes were measured with the modified Ranking Scale (mRS) and the Barthel Index (BI). Functional independence was defined as either mRS Score < 3 or BI > 75 at discharge, discharged home without nursing support with a BI > 65, or discharged to further rehabilitation (phase D). To analyze outcome predictors, Cox regression was used.
Results: A total of 323 patients (COVID-19 n = 166) after an ICU stay were enrolled, and outcome measures were available for 298. 56 of them achieved functional independence at discharge. COVID-19 patients had better functional scores at admission and discharge and a shorter length of stay as the non-COVID group. Pre-existing diabetes was significantly negatively associated with functioning at discharge.
Conclusions: This analysis provides the first evidence for differences and predictors of the clinical course and outcome for COVID-19 and non-COVID-19 patients with CIP/CIM in the phase of post-acute rehabilitation. Our results offer valuable impulses for rehabilitation strategies for these patients. https://drks.de/search/de , German Clinical Trials Register, ID DRKS00022845, registered on September 1, 2020.
Keywords: CIP/CIM; COVID-19; Functioning; Neurology; Neuromuscular; Rehabilitation.
. 2025 Feb 11;272(3):197.
doi: 10.1007/s00415-024-12873-5. Differences in functional outcome of COVID-19 and non-COVID-19 patients with critical illness polyneuropathy/ myopathy: a multicenter cohort study
Michael Klein[SUP] #[/SUP][SUP] 1 [/SUP], Bernadette Einhäupl[SUP] #[/SUP][SUP] 2 [/SUP], Eva Grill[SUP] 1 3 [/SUP], Gergana Drunin[SUP] 4 [/SUP], Simone Schmidt[SUP] 5 [/SUP], Cay Cordes[SUP] 6 [/SUP], Marion Egger[SUP] 1 7 [/SUP], Hans-Jürgen Gdynia[SUP] 8 [/SUP], Anna Gorsler[SUP] 9 [/SUP], Danae Götze[SUP] 10 [/SUP], Jens Dieter Rollnik[SUP] 5 [/SUP], Martin Justinus Rosenfelder[SUP] 10 11 12 [/SUP], Ernst Walther[SUP] 13 [/SUP], Daniel Wertheimer[SUP] 14 [/SUP], Corinna Wimmer[SUP] 10 7 [/SUP], Peter Young[SUP] 15 [/SUP], Klaus Jahn[SUP] #[/SUP][SUP] 3 7 [/SUP], Andreas Bender[SUP] #[/SUP][SUP] 10 11 16 [/SUP]
Affiliations
- PMID: 39932563
- DOI: 10.1007/s00415-024-12873-5
Background: Up to 80% of intensive care unit (ICU) patients suffer from neuromuscular disorders like critical illness polyneuropathy/myopathy (CIP/CIM), requiring further rehabilitation.
Objective: This study investigates differences in the clinical course between Coronavirus Disease 2019 (COVID-19) and non-COVID-19 patients with CIP/CIM undergoing post-acute neurological rehabilitation (PANR) and the impact of COVID-19 on rehabilitation outcomes.
Methods: A multicenter observational study was conducted in nine German PANR facilities. The clinical course and outcome were compared between COVID-19 and non-COVID-19 patients at rehabilitation admission and discharge. Functional outcomes were measured with the modified Ranking Scale (mRS) and the Barthel Index (BI). Functional independence was defined as either mRS Score < 3 or BI > 75 at discharge, discharged home without nursing support with a BI > 65, or discharged to further rehabilitation (phase D). To analyze outcome predictors, Cox regression was used.
Results: A total of 323 patients (COVID-19 n = 166) after an ICU stay were enrolled, and outcome measures were available for 298. 56 of them achieved functional independence at discharge. COVID-19 patients had better functional scores at admission and discharge and a shorter length of stay as the non-COVID group. Pre-existing diabetes was significantly negatively associated with functioning at discharge.
Conclusions: This analysis provides the first evidence for differences and predictors of the clinical course and outcome for COVID-19 and non-COVID-19 patients with CIP/CIM in the phase of post-acute rehabilitation. Our results offer valuable impulses for rehabilitation strategies for these patients. https://drks.de/search/de , German Clinical Trials Register, ID DRKS00022845, registered on September 1, 2020.
Keywords: CIP/CIM; COVID-19; Functioning; Neurology; Neuromuscular; Rehabilitation.