tetano
Editor, Senior Moderator
J Neuroimmunol
. 2020 Nov 7;350:577436.
doi: 10.1016/j.jneuroim.2020.577436. Online ahead of print.
SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation
Kiandokht Keyhanian[SUP] 1 [/SUP], Raffaella Pizzolato Umeton[SUP] 2 [/SUP], Babak Mohit[SUP] 3 [/SUP], Vahid Davoudi[SUP] 4 [/SUP], Fatemeh Hajighasemi[SUP] 5 [/SUP], Mehdi Ghasemi[SUP] 6 [/SUP]
Affiliations
Abstract
Since the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a growing body of evidence indicates that besides common COVID-19 symptoms, patients may develop various neurological manifestations affecting both the central and peripheral nervous systems as well as skeletal muscles. These manifestations can occur prior, during and even after the onset of COVID-19 general symptoms. In this Review, we discuss the possible neuroimmunological mechanisms underlying the nervous system and skeletal muscle involvement, and viral triggered neuroimmunological conditions associated with SARS-CoV-2, as well as therapeutic approaches that have been considered for these specific complications worldwide.
Keywords: Coronavirus disease 2019 (COVID-19); Encephalitis; Guillain-Barr? syndromes; Myelitis; Neuroimmunity; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
. 2020 Nov 7;350:577436.
doi: 10.1016/j.jneuroim.2020.577436. Online ahead of print.
SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation
Kiandokht Keyhanian[SUP] 1 [/SUP], Raffaella Pizzolato Umeton[SUP] 2 [/SUP], Babak Mohit[SUP] 3 [/SUP], Vahid Davoudi[SUP] 4 [/SUP], Fatemeh Hajighasemi[SUP] 5 [/SUP], Mehdi Ghasemi[SUP] 6 [/SUP]
Affiliations
- PMID: 33212316
- PMCID: PMC7647896
- DOI: 10.1016/j.jneuroim.2020.577436
Abstract
Since the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a growing body of evidence indicates that besides common COVID-19 symptoms, patients may develop various neurological manifestations affecting both the central and peripheral nervous systems as well as skeletal muscles. These manifestations can occur prior, during and even after the onset of COVID-19 general symptoms. In this Review, we discuss the possible neuroimmunological mechanisms underlying the nervous system and skeletal muscle involvement, and viral triggered neuroimmunological conditions associated with SARS-CoV-2, as well as therapeutic approaches that have been considered for these specific complications worldwide.
Keywords: Coronavirus disease 2019 (COVID-19); Encephalitis; Guillain-Barr? syndromes; Myelitis; Neuroimmunity; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).