tetano
Editor, Senior Moderator
J Microbiol
. 2022 Feb 5.
doi: 10.1007/s12275-022-1525-1. Online ahead of print.
SARS-CoV-2-mediated evasion strategies for antiviral interferon pathways
Soo-Jin Oh[SUP] 1 [/SUP], Ok Sarah Shin[SUP] 2 [/SUP]
Affiliations
Abstract
With global expansion of the COVID-19 pandemic and the emergence of new variants, extensive efforts have been made to develop highly effective antiviral drugs and vaccines against SARS-CoV-2. The interactions of coronaviruses with host antiviral interferon pathways ultimately determine successful viral replication and SARS-CoV-2-induced pathogenesis. Innate immune receptors play an essential role in host defense against SARS-CoV-2 via the induction of IFN production and signaling. Here, we summarize the recent advances in innate immune sensing mechanisms of SARS-CoV-2 and various strategies by which SARS-CoV-2 antagonizes antiviral innate immune signaling pathways, with a particular focus on mechanisms utilized by multiple SARS-CoV-2 proteins to evade interferon induction and signaling in host cell. Understanding the underlying immune evasion mechanisms of SARS-CoV-2 is essential for the improvement of vaccines and therapeutic strategies.
Keywords: COVID-19; SARS-CoV-2; immunity; interferon.
. 2022 Feb 5.
doi: 10.1007/s12275-022-1525-1. Online ahead of print.
SARS-CoV-2-mediated evasion strategies for antiviral interferon pathways
Soo-Jin Oh[SUP] 1 [/SUP], Ok Sarah Shin[SUP] 2 [/SUP]
Affiliations
- PMID: 35122601
- DOI: 10.1007/s12275-022-1525-1
Abstract
With global expansion of the COVID-19 pandemic and the emergence of new variants, extensive efforts have been made to develop highly effective antiviral drugs and vaccines against SARS-CoV-2. The interactions of coronaviruses with host antiviral interferon pathways ultimately determine successful viral replication and SARS-CoV-2-induced pathogenesis. Innate immune receptors play an essential role in host defense against SARS-CoV-2 via the induction of IFN production and signaling. Here, we summarize the recent advances in innate immune sensing mechanisms of SARS-CoV-2 and various strategies by which SARS-CoV-2 antagonizes antiviral innate immune signaling pathways, with a particular focus on mechanisms utilized by multiple SARS-CoV-2 proteins to evade interferon induction and signaling in host cell. Understanding the underlying immune evasion mechanisms of SARS-CoV-2 is essential for the improvement of vaccines and therapeutic strategies.
Keywords: COVID-19; SARS-CoV-2; immunity; interferon.