tetano
Editor, Senior Moderator
J Med Virol
. 2022 Oct 12.
doi: 10.1002/jmv.28212. Online ahead of print.
Spike protein mediated membrane fusion during SARS-CoV-2 infection
Xinyu Li[SUP] 1 [/SUP], Huijun Yuan[SUP] 1 [/SUP], Xiaozhen Li, Hongliang Wang[SUP] 1 2 [/SUP]
Affiliations
Abstract
The pandemic caused by SARS-CoV-2 has posed a serious threat to public health and has quickly become a global concern. The infection of SARS-CoV-2 begins with the binding of its spike protein to the receptor- angiotensin-converting enzyme 2(ACE2), which, after a series of conformation changes, results in the fusion of viral-cell membranes and the release of the viral RNA genome into the cytoplasm. In addition, infected host cells can express spike protein on their cell surface, which will interact with ACE2 on neighboring cells, leading to cell membrane fusion and the formation of multinucleated cells or syncytia. Both viral entry and syncytia formation are mediated by spike-ACE2 interaction and share some common mechanisms of membrane fusion. Here in this review, we will summarize our current understanding of spike-mediated membrane fusion, which may shed light on future broad-spectrum antiviral development. This article is protected by copyright. All rights reserved.
Keywords: Antiviral agents; Cell fusion; Cellular Effect; Coronavirus; Entry inhibitors; Virus classification.
. 2022 Oct 12.
doi: 10.1002/jmv.28212. Online ahead of print.
Spike protein mediated membrane fusion during SARS-CoV-2 infection
Xinyu Li[SUP] 1 [/SUP], Huijun Yuan[SUP] 1 [/SUP], Xiaozhen Li, Hongliang Wang[SUP] 1 2 [/SUP]
Affiliations
- PMID: 36224449
- DOI: 10.1002/jmv.28212
Abstract
The pandemic caused by SARS-CoV-2 has posed a serious threat to public health and has quickly become a global concern. The infection of SARS-CoV-2 begins with the binding of its spike protein to the receptor- angiotensin-converting enzyme 2(ACE2), which, after a series of conformation changes, results in the fusion of viral-cell membranes and the release of the viral RNA genome into the cytoplasm. In addition, infected host cells can express spike protein on their cell surface, which will interact with ACE2 on neighboring cells, leading to cell membrane fusion and the formation of multinucleated cells or syncytia. Both viral entry and syncytia formation are mediated by spike-ACE2 interaction and share some common mechanisms of membrane fusion. Here in this review, we will summarize our current understanding of spike-mediated membrane fusion, which may shed light on future broad-spectrum antiviral development. This article is protected by copyright. All rights reserved.
Keywords: Antiviral agents; Cell fusion; Cellular Effect; Coronavirus; Entry inhibitors; Virus classification.