tetano
Editor, Senior Moderator
J Med Virol
. 2025 Nov;97(11):e70687.
doi: 10.1002/jmv.70687. One-Year Quality of Life Among Survivors of Hospitalization for Omicron Infection in Brazil: A Multicentre Prospective Cohort Study
Geraldine Trott[SUP] 1 [/SUP], Marciane Maria Rover[SUP] 1 2 3 [/SUP], Fernando Luis Scolari[SUP] 1 2 [/SUP], Mariana Motta Dias da Silva[SUP] 4 [/SUP], Denise de Souza[SUP] 1 [/SUP], Rosa da Rosa Minho Dos Santos[SUP] 1 [/SUP], Raíne Fogliati De Carli[SUP] 1 [/SUP], Emelyn de Souza Roldão[SUP] 1 [/SUP], Gabriela Soares Rech[SUP] 1 [/SUP], Duane Mocellin[SUP] 1 [/SUP], Jennifer Menna Barreto de Souza[SUP] 1 [/SUP], Aline Paula Miozzo[SUP] 1 [/SUP], Carolina Rothmann Itaqui[SUP] 1 [/SUP], Gabrielle Nunes da Silva[SUP] 1 [/SUP], Sergio Renato da Rosa Decker[SUP] 1 3 5 [/SUP], Erica Neves Leite[SUP] 1 [/SUP], Carlos Delmar do Amaral Ferreira[SUP] 6 [/SUP], Lucas Gobetti da Luz[SUP] 6 7 [/SUP], Gabriel Beilfuss Rieth[SUP] 6 [/SUP], Lucas Tramujas[SUP] 8 [/SUP], Fernando Azevedo Medrado[SUP] 8 [/SUP], Bruna Fornazieri Piotto[SUP] 8 [/SUP], Gizelle Fernanda Oliveira Silva[SUP] 9 [/SUP], Josafá Ferreira Chaves[SUP] 9 [/SUP], Saionara Cristina Francisco[SUP] 9 [/SUP], Precil Diego Miranda de Menezes Neves[SUP] 10 [/SUP], Victor Augusto Hamamoto Sato[SUP] 10 [/SUP], Viviane Cordeiro Veiga[SUP] 11 [/SUP], Kaique Lima Martins[SUP] 11 [/SUP], Cláudio Dornas de Oliveira[SUP] 12 [/SUP], Sabrina Gomes Dos Santos[SUP] 12 [/SUP], Juliana Cardozo Fernandes[SUP] 13 [/SUP], Thiago Costa Lisboa[SUP] 14 [/SUP], Vivian Menezes Irineu[SUP] 15 [/SUP], Mauricio Antonio Pompilio[SUP] 16 [/SUP], Adriana de Oliveira França[SUP] 16 [/SUP], Aline Coletto Jaccottet[SUP] 17 [/SUP], Juliana Carvalho Schleder[SUP] 18 [/SUP], Vinicius Ortigosa Nogueira[SUP] 19 [/SUP], Vandack Nobre[SUP] 20 [/SUP], Daniel Souto Silveira[SUP] 21 [/SUP], Cézar Eumann Mesas[SUP] 22 [/SUP], Diego Miltersteiner[SUP] 23 [/SUP], Emanuelle Toledo Ortiz[SUP] 23 [/SUP], Fernando Gioppo Blauth[SUP] 24 [/SUP], Luciane Maria Facchi[SUP] 25 [/SUP], Milena Soriano Marcolino[SUP] 26 27 [/SUP], Ana Carolina Peçanha Antonio[SUP] 14 [/SUP], Paulo R Schvartzman[SUP] 2 [/SUP], Bruna Brandão Barreto[SUP] 28 [/SUP], Caroline Cabral Robinson[SUP] 1 [/SUP], Maicon Falavigna[SUP] 5 27 [/SUP], Carisi Anne Polanczyk[SUP] 2 3 7 14 27 [/SUP], Luiz Antonio Nasi[SUP] 6 [/SUP], Regis Goulart Rosa[SUP] 1 29 30 [/SUP]; Post‐Covid Brasil 1 Group Autorship
Affiliations
The lingering effects of COVID-19 may impair survivors' long-term health-related quality of life (HRQoL). However, multicentre studies focusing on the Omicron variant, particularly in middle- and low-income settings, are scarce. We conducted a prospective cohort study across 24 Brazilian hospitals between December 2021 and March 2024, when Omicron was the predominant variant. Adult COVID-19 survivors were followed for 12 months via telephone interviews. The primary outcome was HRQoL at 12 months, assessed using the EuroQol five-dimension three-level questionnaire (EQ-5D-3L; range -0.17 to 1.0). All-cause mortality was a secondary outcome. Among 649 participants (47.9% women; median age 71 years), the median EQ-5D-3L utility score at 12 months was 0.69 (IQR 0.41-0.80), and survival was 86.6%. Factors associated with lower HRQoL included female sex, age ≥ 60 years, Charlson comorbidity index ≥ 1, and need for respiratory support. Mortality was associated with age ≥ 60 years (HR 2.81), CCI ≥ 2 (HR 2.17), need for low-flow oxygen therapy (HR 2.03), and BMI ≥ 25 kg/m² (HR 0.58). One year after hospitalization, Omicron survivors in Brazil showed impaired HRQoL and high mortality. Older age, comorbidities, and need for oxygen therapy were linked to worse outcomes. Long-term support strategies are needed for these vulnerable populations.
Keywords: Brazil; COVID‐19; Omicron variant; SARS‐CoV‐2; post‐acute COVID‐19 syndrome; quality of life.
. 2025 Nov;97(11):e70687.
doi: 10.1002/jmv.70687. One-Year Quality of Life Among Survivors of Hospitalization for Omicron Infection in Brazil: A Multicentre Prospective Cohort Study
Geraldine Trott[SUP] 1 [/SUP], Marciane Maria Rover[SUP] 1 2 3 [/SUP], Fernando Luis Scolari[SUP] 1 2 [/SUP], Mariana Motta Dias da Silva[SUP] 4 [/SUP], Denise de Souza[SUP] 1 [/SUP], Rosa da Rosa Minho Dos Santos[SUP] 1 [/SUP], Raíne Fogliati De Carli[SUP] 1 [/SUP], Emelyn de Souza Roldão[SUP] 1 [/SUP], Gabriela Soares Rech[SUP] 1 [/SUP], Duane Mocellin[SUP] 1 [/SUP], Jennifer Menna Barreto de Souza[SUP] 1 [/SUP], Aline Paula Miozzo[SUP] 1 [/SUP], Carolina Rothmann Itaqui[SUP] 1 [/SUP], Gabrielle Nunes da Silva[SUP] 1 [/SUP], Sergio Renato da Rosa Decker[SUP] 1 3 5 [/SUP], Erica Neves Leite[SUP] 1 [/SUP], Carlos Delmar do Amaral Ferreira[SUP] 6 [/SUP], Lucas Gobetti da Luz[SUP] 6 7 [/SUP], Gabriel Beilfuss Rieth[SUP] 6 [/SUP], Lucas Tramujas[SUP] 8 [/SUP], Fernando Azevedo Medrado[SUP] 8 [/SUP], Bruna Fornazieri Piotto[SUP] 8 [/SUP], Gizelle Fernanda Oliveira Silva[SUP] 9 [/SUP], Josafá Ferreira Chaves[SUP] 9 [/SUP], Saionara Cristina Francisco[SUP] 9 [/SUP], Precil Diego Miranda de Menezes Neves[SUP] 10 [/SUP], Victor Augusto Hamamoto Sato[SUP] 10 [/SUP], Viviane Cordeiro Veiga[SUP] 11 [/SUP], Kaique Lima Martins[SUP] 11 [/SUP], Cláudio Dornas de Oliveira[SUP] 12 [/SUP], Sabrina Gomes Dos Santos[SUP] 12 [/SUP], Juliana Cardozo Fernandes[SUP] 13 [/SUP], Thiago Costa Lisboa[SUP] 14 [/SUP], Vivian Menezes Irineu[SUP] 15 [/SUP], Mauricio Antonio Pompilio[SUP] 16 [/SUP], Adriana de Oliveira França[SUP] 16 [/SUP], Aline Coletto Jaccottet[SUP] 17 [/SUP], Juliana Carvalho Schleder[SUP] 18 [/SUP], Vinicius Ortigosa Nogueira[SUP] 19 [/SUP], Vandack Nobre[SUP] 20 [/SUP], Daniel Souto Silveira[SUP] 21 [/SUP], Cézar Eumann Mesas[SUP] 22 [/SUP], Diego Miltersteiner[SUP] 23 [/SUP], Emanuelle Toledo Ortiz[SUP] 23 [/SUP], Fernando Gioppo Blauth[SUP] 24 [/SUP], Luciane Maria Facchi[SUP] 25 [/SUP], Milena Soriano Marcolino[SUP] 26 27 [/SUP], Ana Carolina Peçanha Antonio[SUP] 14 [/SUP], Paulo R Schvartzman[SUP] 2 [/SUP], Bruna Brandão Barreto[SUP] 28 [/SUP], Caroline Cabral Robinson[SUP] 1 [/SUP], Maicon Falavigna[SUP] 5 27 [/SUP], Carisi Anne Polanczyk[SUP] 2 3 7 14 27 [/SUP], Luiz Antonio Nasi[SUP] 6 [/SUP], Regis Goulart Rosa[SUP] 1 29 30 [/SUP]; Post‐Covid Brasil 1 Group Autorship
Affiliations
- PMID: 41251137
- DOI: 10.1002/jmv.70687
The lingering effects of COVID-19 may impair survivors' long-term health-related quality of life (HRQoL). However, multicentre studies focusing on the Omicron variant, particularly in middle- and low-income settings, are scarce. We conducted a prospective cohort study across 24 Brazilian hospitals between December 2021 and March 2024, when Omicron was the predominant variant. Adult COVID-19 survivors were followed for 12 months via telephone interviews. The primary outcome was HRQoL at 12 months, assessed using the EuroQol five-dimension three-level questionnaire (EQ-5D-3L; range -0.17 to 1.0). All-cause mortality was a secondary outcome. Among 649 participants (47.9% women; median age 71 years), the median EQ-5D-3L utility score at 12 months was 0.69 (IQR 0.41-0.80), and survival was 86.6%. Factors associated with lower HRQoL included female sex, age ≥ 60 years, Charlson comorbidity index ≥ 1, and need for respiratory support. Mortality was associated with age ≥ 60 years (HR 2.81), CCI ≥ 2 (HR 2.17), need for low-flow oxygen therapy (HR 2.03), and BMI ≥ 25 kg/m² (HR 0.58). One year after hospitalization, Omicron survivors in Brazil showed impaired HRQoL and high mortality. Older age, comorbidities, and need for oxygen therapy were linked to worse outcomes. Long-term support strategies are needed for these vulnerable populations.
Keywords: Brazil; COVID‐19; Omicron variant; SARS‐CoV‐2; post‐acute COVID‐19 syndrome; quality of life.