tetano
Editor, Senior Moderator
J Med Virol
. 2022 Apr 27.
doi: 10.1002/jmv.27817. Online ahead of print.
Influenza is More Severe than Our Newest Enemy (COVID-19) in Hospitalized Children: Experience from a Tertiary Center
Selin Tasar[SUP] 1 [/SUP], Eda Karadag-Oncel[SUP] 1 [/SUP], Dilek Yilmaz-Ciftdogan[SUP] 1 2 [/SUP], Ahu Kara-Aksay[SUP] 1 [/SUP], Yildiz Ekemen-Keles[SUP] 1 [/SUP], Aysegul Elvan-Tuz[SUP] 1 [/SUP], Gulnihan Ustundag[SUP] 1 [/SUP], Aslihan Sahin[SUP] 1 [/SUP], Muhammet Ali Kanık[SUP] 3 [/SUP], Nisel Yılmaz[SUP] 4 [/SUP]
Affiliations
Abstract
Background: Understanding differences in terms of clinical phenotypes and outcomes of COVID-19 compared with influenza is vital to optimize the management of patients and to plan healthcare.Herein,we aimed to investigate the clinical differences and outcomes in hospitalized patients with SARS-CoV-2 and influenza.
Methods: We performed a retrospective study of hospitalized children who were positive for SARS-CoV-2 between March 2020 and March 2021 and for influenza between January 2016 and February 2020 in respiratory samples.The primary outcome of this study was pediatric intensive care unit (PICU) admission,and the secondary outcome was the need for respiratory support.
Results: A total of 74 patients with influenza and 71 who were positive for SARS-CoV-2 were included.The distribution among the sexes was similar,but patients with COVID-19 were older than patients with influenza (96 months vs. 12 months,p<0.001).In terms of underlying chronic diseases, the frequency was 26.7% in the COVID-19 group and 54% in the influenza group (p=0.001).The comparison of symptoms revealed that fatigue, headache, nausea, vomiting, and abdominal pain occurred more frequently with COVID-19 (for all p<0.05) and runny nose with influenza (p=0.002).The frequency of admission to the PICU was relatively higher (18.9%) in the influenza group than with COVID-19 (2.8%) with a significant ratio (p=0.001),secondary bacterial infections were observed more frequently in the influenza group (20.2% vs. 4.2%, p=0.003).Some 88.7% of patients with COVID-19 did not need respiratory support,whereas 59.4% of patients with influenza did require respiratory support (p<0.001).
Conclusions: This study noted that influenza caused more frequent admissions to the PICU and a greater need for respiratory support in hospitalized pediatric patients than COVID-19. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; children; hospitalized; influenza; outcome.
. 2022 Apr 27.
doi: 10.1002/jmv.27817. Online ahead of print.
Influenza is More Severe than Our Newest Enemy (COVID-19) in Hospitalized Children: Experience from a Tertiary Center
Selin Tasar[SUP] 1 [/SUP], Eda Karadag-Oncel[SUP] 1 [/SUP], Dilek Yilmaz-Ciftdogan[SUP] 1 2 [/SUP], Ahu Kara-Aksay[SUP] 1 [/SUP], Yildiz Ekemen-Keles[SUP] 1 [/SUP], Aysegul Elvan-Tuz[SUP] 1 [/SUP], Gulnihan Ustundag[SUP] 1 [/SUP], Aslihan Sahin[SUP] 1 [/SUP], Muhammet Ali Kanık[SUP] 3 [/SUP], Nisel Yılmaz[SUP] 4 [/SUP]
Affiliations
- PMID: 35477866
- DOI: 10.1002/jmv.27817
Abstract
Background: Understanding differences in terms of clinical phenotypes and outcomes of COVID-19 compared with influenza is vital to optimize the management of patients and to plan healthcare.Herein,we aimed to investigate the clinical differences and outcomes in hospitalized patients with SARS-CoV-2 and influenza.
Methods: We performed a retrospective study of hospitalized children who were positive for SARS-CoV-2 between March 2020 and March 2021 and for influenza between January 2016 and February 2020 in respiratory samples.The primary outcome of this study was pediatric intensive care unit (PICU) admission,and the secondary outcome was the need for respiratory support.
Results: A total of 74 patients with influenza and 71 who were positive for SARS-CoV-2 were included.The distribution among the sexes was similar,but patients with COVID-19 were older than patients with influenza (96 months vs. 12 months,p<0.001).In terms of underlying chronic diseases, the frequency was 26.7% in the COVID-19 group and 54% in the influenza group (p=0.001).The comparison of symptoms revealed that fatigue, headache, nausea, vomiting, and abdominal pain occurred more frequently with COVID-19 (for all p<0.05) and runny nose with influenza (p=0.002).The frequency of admission to the PICU was relatively higher (18.9%) in the influenza group than with COVID-19 (2.8%) with a significant ratio (p=0.001),secondary bacterial infections were observed more frequently in the influenza group (20.2% vs. 4.2%, p=0.003).Some 88.7% of patients with COVID-19 did not need respiratory support,whereas 59.4% of patients with influenza did require respiratory support (p<0.001).
Conclusions: This study noted that influenza caused more frequent admissions to the PICU and a greater need for respiratory support in hospitalized pediatric patients than COVID-19. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; children; hospitalized; influenza; outcome.