tetano
Editor, Senior Moderator
J Med Virol
. 2021 May 3.
doi: 10.1002/jmv.27032. Online ahead of print.
Feasibility of convalescent plasma therapy in severe COVID-19 patients with persistent SARS-CoV-2 viremia
Fabrice Camou[SUP] 1 [/SUP], Claire Tinevez[SUP] 1 [/SUP], Mathilde Beguet-Yachine[SUP] 2 [/SUP], Pantxika Bellecave[SUP] 3 [/SUP], Diana Ratiarison[SUP] 2 [/SUP], Camille Tumiotto[SUP] 3 4 [/SUP], Xavier Lafarge[SUP] 2 5 [/SUP], Olivier Guisset[SUP] 1 [/SUP], Ga?lle Mourissoux[SUP] 1 [/SUP], Marie-Edith Lafon[SUP] 3 4 [/SUP], Fabrice Bonnet[SUP] 6 [/SUP], Nah?ma Issa[SUP] 1 [/SUP]
Affiliations
Abstract
This study aims to assess the efficacy and safety of convalescent plasma therapy (CPT) in COVID-19 critically ill patients with protracted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNAemia. A retrospective cohort study was conducted in intensive care unit (ICU). All patients with severe COVID-19 pneumonia for whom RNAemia remained positive more than 14 days after onset of the infection were included and given CPT. The primary objective was to evaluate SARS-CoV-2 RNAemia 7 days (D7) after CPT. A total of 14 patients were included and they received a median CPT volume of 828 ml (range: 817-960). CPT was administered in a median time of 14 days after ICU admission. At D7, 13/14 patients had negative SARS-CoV-2 blood PCR and one patient had negative blood PCR 11 days after CPT. At D7 and at D14, the clinical status was improved in 7/14 and 11/14 patients, respectively. The 28-day mortality rate was 14%. No CPT-related adverse effects had been reported. CPT is safe and may be efficient in patients with protracted RNAemia admitted in ICU for severe COVID-19 pneumonia. Randomized controlled trials are needed to confirm these results.
Keywords: SARS coronavirus; combination therapy; disease control; generalized infection; pathogenesis; virus classification.
. 2021 May 3.
doi: 10.1002/jmv.27032. Online ahead of print.
Feasibility of convalescent plasma therapy in severe COVID-19 patients with persistent SARS-CoV-2 viremia
Fabrice Camou[SUP] 1 [/SUP], Claire Tinevez[SUP] 1 [/SUP], Mathilde Beguet-Yachine[SUP] 2 [/SUP], Pantxika Bellecave[SUP] 3 [/SUP], Diana Ratiarison[SUP] 2 [/SUP], Camille Tumiotto[SUP] 3 4 [/SUP], Xavier Lafarge[SUP] 2 5 [/SUP], Olivier Guisset[SUP] 1 [/SUP], Ga?lle Mourissoux[SUP] 1 [/SUP], Marie-Edith Lafon[SUP] 3 4 [/SUP], Fabrice Bonnet[SUP] 6 [/SUP], Nah?ma Issa[SUP] 1 [/SUP]
Affiliations
- PMID: 33942327
- DOI: 10.1002/jmv.27032
Abstract
This study aims to assess the efficacy and safety of convalescent plasma therapy (CPT) in COVID-19 critically ill patients with protracted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNAemia. A retrospective cohort study was conducted in intensive care unit (ICU). All patients with severe COVID-19 pneumonia for whom RNAemia remained positive more than 14 days after onset of the infection were included and given CPT. The primary objective was to evaluate SARS-CoV-2 RNAemia 7 days (D7) after CPT. A total of 14 patients were included and they received a median CPT volume of 828 ml (range: 817-960). CPT was administered in a median time of 14 days after ICU admission. At D7, 13/14 patients had negative SARS-CoV-2 blood PCR and one patient had negative blood PCR 11 days after CPT. At D7 and at D14, the clinical status was improved in 7/14 and 11/14 patients, respectively. The 28-day mortality rate was 14%. No CPT-related adverse effects had been reported. CPT is safe and may be efficient in patients with protracted RNAemia admitted in ICU for severe COVID-19 pneumonia. Randomized controlled trials are needed to confirm these results.
Keywords: SARS coronavirus; combination therapy; disease control; generalized infection; pathogenesis; virus classification.