tetano
Editor, Senior Moderator
J Med Virol
. 2020 Jul 9.
doi: 10.1002/jmv.26284. Online ahead of print.
Erythropoietin Induced Hemoglobin Sub-Unit Beta May Stimulate Innate Immune RNA Virus Pattern Recognition, Suppress Reactive Oxygen Species, Reduce ACE2 Viral Doorway Opening and Neutrophil Extracellular Traps Against Covid-19
Steven Robert Brenner[SUP] 1 [/SUP]
Affiliations
Abstract
Erythropoietin may stimulate innate immunity against RNA viruses, such as Covid-19, through hemoglobin sub-unit Beta acting on the retinoic acid inducible gene I (RIG-1) and melanoma differentiation associated gene 5 (MDA5) viral pattern recognition receptors, causing interferon production and also maintains the vascular endothelium, a major target of SARS-CoV-2, possibly reducing thrombotic events which are becoming increasingly recognized complications of COVID19. This article is protected by copyright. All rights reserved.
Keywords: Disease control; Immune responses; Innate immunity; Interferons; Pathogenesis; Respiratory tract; SARS coronavirus; Tissue tropism; Virus classification.
. 2020 Jul 9.
doi: 10.1002/jmv.26284. Online ahead of print.
Erythropoietin Induced Hemoglobin Sub-Unit Beta May Stimulate Innate Immune RNA Virus Pattern Recognition, Suppress Reactive Oxygen Species, Reduce ACE2 Viral Doorway Opening and Neutrophil Extracellular Traps Against Covid-19
Steven Robert Brenner[SUP] 1 [/SUP]
Affiliations
- PMID: 32644208
- DOI: 10.1002/jmv.26284
Abstract
Erythropoietin may stimulate innate immunity against RNA viruses, such as Covid-19, through hemoglobin sub-unit Beta acting on the retinoic acid inducible gene I (RIG-1) and melanoma differentiation associated gene 5 (MDA5) viral pattern recognition receptors, causing interferon production and also maintains the vascular endothelium, a major target of SARS-CoV-2, possibly reducing thrombotic events which are becoming increasingly recognized complications of COVID19. This article is protected by copyright. All rights reserved.
Keywords: Disease control; Immune responses; Innate immunity; Interferons; Pathogenesis; Respiratory tract; SARS coronavirus; Tissue tropism; Virus classification.