tetano
Editor, Senior Moderator
J Med Virol
. 2025 Jun;97(6):e70410.
doi: 10.1002/jmv.70410. Dynamic Molecular Changes in Brain, Lung, and Heart of Hamsters Infected With SARS-CoV-2: Insights From a Severe and Recovery Phase Model
Wanjun Peng[SUP] 1 2 [/SUP], Xiaohui Wei[SUP] 2 [/SUP], Yue Wu[SUP] 1 [/SUP], Chunmei Shi[SUP] 1 [/SUP], Xiaoyan Liu[SUP] 1 [/SUP], Jing Wu[SUP] 2 [/SUP], Hekai Yang[SUP] 2 [/SUP], Na Rong[SUP] 2 [/SUP], Binbin Zhao[SUP] 2 [/SUP], Gengxin Zhang[SUP] 2 [/SUP], Wei Zhang[SUP] 2 [/SUP], Jiangfeng Liu[SUP] 1 [/SUP], Jiangning Liu[SUP] 2 [/SUP], Juntao Yang[SUP] 1 3 [/SUP]
Affiliations
The Global pandemic of coronavirus disease 2019 was initiated by the emergence of severe acute respiratory syndrome coronavirus 2. In addition to conventional pulmonary lesions, a range of neurological injury symptoms have been identified in clinical practice, but the aetiology of neurological disorders linked to SARS-CoV-2 infection remains poorly understood. Syrian hamsters, which are highly susceptible to SARS-CoV-2 infection, exhibit a disease phenotype similar to that observed in human COVID-19 patients. In this study, a hamster model of COVID-19 infection was used to analyze molecular changes in different tissues at various time points post infection with distinct strains using proteomic and phosphoproteomic approaches. Multi-omics analysis showed that SARS-COV-2 infection triggers sustained downregulation of the abundance and phosphorylation levels of neuronal and synapse-associated proteins in the brain, suggesting that neuronal damage persists even during the recovery period. Additionally, infections with SARS-CoV-2 may contribute to the onset of long-term symptoms of COVID-19 by impacting energy metabolism, neurotransmitter release, and synaptic transmission pathways. This study provides a comprehensive molecular profile of hamsters infected with different SARS-CoV-2 strains in different tissues, offering foundational insights into the pathogenic mechanisms of COVID-19.
Keywords: Omicron; SARS‐CoV‐2; phosphoproteomics; proteomics; prototype.
. 2025 Jun;97(6):e70410.
doi: 10.1002/jmv.70410. Dynamic Molecular Changes in Brain, Lung, and Heart of Hamsters Infected With SARS-CoV-2: Insights From a Severe and Recovery Phase Model
Wanjun Peng[SUP] 1 2 [/SUP], Xiaohui Wei[SUP] 2 [/SUP], Yue Wu[SUP] 1 [/SUP], Chunmei Shi[SUP] 1 [/SUP], Xiaoyan Liu[SUP] 1 [/SUP], Jing Wu[SUP] 2 [/SUP], Hekai Yang[SUP] 2 [/SUP], Na Rong[SUP] 2 [/SUP], Binbin Zhao[SUP] 2 [/SUP], Gengxin Zhang[SUP] 2 [/SUP], Wei Zhang[SUP] 2 [/SUP], Jiangfeng Liu[SUP] 1 [/SUP], Jiangning Liu[SUP] 2 [/SUP], Juntao Yang[SUP] 1 3 [/SUP]
Affiliations
- PMID: 40432336
- DOI: 10.1002/jmv.70410
The Global pandemic of coronavirus disease 2019 was initiated by the emergence of severe acute respiratory syndrome coronavirus 2. In addition to conventional pulmonary lesions, a range of neurological injury symptoms have been identified in clinical practice, but the aetiology of neurological disorders linked to SARS-CoV-2 infection remains poorly understood. Syrian hamsters, which are highly susceptible to SARS-CoV-2 infection, exhibit a disease phenotype similar to that observed in human COVID-19 patients. In this study, a hamster model of COVID-19 infection was used to analyze molecular changes in different tissues at various time points post infection with distinct strains using proteomic and phosphoproteomic approaches. Multi-omics analysis showed that SARS-COV-2 infection triggers sustained downregulation of the abundance and phosphorylation levels of neuronal and synapse-associated proteins in the brain, suggesting that neuronal damage persists even during the recovery period. Additionally, infections with SARS-CoV-2 may contribute to the onset of long-term symptoms of COVID-19 by impacting energy metabolism, neurotransmitter release, and synaptic transmission pathways. This study provides a comprehensive molecular profile of hamsters infected with different SARS-CoV-2 strains in different tissues, offering foundational insights into the pathogenic mechanisms of COVID-19.
Keywords: Omicron; SARS‐CoV‐2; phosphoproteomics; proteomics; prototype.