tetano
Editor, Senior Moderator
J Med Virol
. 2020 Jul 9.
doi: 10.1002/jmv.26280. Online ahead of print.
Duration of SARS-CoV-2 RNA Shedding and Factors Associated With Prolonged Viral Shedding in Patients With COVID-19
Tong-Zeng Li[SUP] 1 [/SUP], Zhen-Huan Cao[SUP] 1 [/SUP], Yu Chen[SUP] 2 [/SUP], Miao-Tian Cai[SUP] 1 [/SUP], Long-Yu Zhang[SUP] 1 [/SUP], Hui Xu[SUP] 1 [/SUP], Jia-Ying Zhang[SUP] 1 [/SUP], Chun-Hua Ma[SUP] 1 [/SUP], Yang Liu[SUP] 1 [/SUP], Li-Juan Gao[SUP] 1 [/SUP], Zhong-Hui Duan[SUP] 1 [/SUP], Dan-Lei Mou[SUP] 1 [/SUP], Lian-Chun Liang[SUP] 1 [/SUP]
Affiliations
Abstract
Aim: To investigate the factors associated with the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA shedding in patients with coronavirus disease 2019 (COVID-19).
Methods: A retrospective cohort of COVID-19 patients admitted to a designated hospital in Beijing was analyzed to study the factors affecting the duration of viral shedding.
Results: The median duration of viral shedding was 11 days (IQR, 8-14.3 days) as measured from illness onset. Univariate regression analysis showed that disease severity, corticosteroid therapy, fever (temperature>38.5℃), and time from onset to hospitalization were associated with prolonged duration of viral shedding (p<0.05). Multivariate regression analysis showed that fever (temperature>38.5℃) (OR 5.1, 95%CI: 1.5-18.1), corticosteroid therapy (OR 6.3, 95%CI: 1.5-27.8), and time from onset to hospitalization (OR 1.8, 95%CI: 1.19-2.7) were associated with increased odds of prolonged duration of viral shedding.
Conclusions: Corticosteroid treatment, fever (temperature>38.5℃), and longer time from onset to hospitalization were associated with prolonged viral shedding in COVID-19 patients. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Coronavirus; duration of viral shedding.
. 2020 Jul 9.
doi: 10.1002/jmv.26280. Online ahead of print.
Duration of SARS-CoV-2 RNA Shedding and Factors Associated With Prolonged Viral Shedding in Patients With COVID-19
Tong-Zeng Li[SUP] 1 [/SUP], Zhen-Huan Cao[SUP] 1 [/SUP], Yu Chen[SUP] 2 [/SUP], Miao-Tian Cai[SUP] 1 [/SUP], Long-Yu Zhang[SUP] 1 [/SUP], Hui Xu[SUP] 1 [/SUP], Jia-Ying Zhang[SUP] 1 [/SUP], Chun-Hua Ma[SUP] 1 [/SUP], Yang Liu[SUP] 1 [/SUP], Li-Juan Gao[SUP] 1 [/SUP], Zhong-Hui Duan[SUP] 1 [/SUP], Dan-Lei Mou[SUP] 1 [/SUP], Lian-Chun Liang[SUP] 1 [/SUP]
Affiliations
- PMID: 32644223
- DOI: 10.1002/jmv.26280
Abstract
Aim: To investigate the factors associated with the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA shedding in patients with coronavirus disease 2019 (COVID-19).
Methods: A retrospective cohort of COVID-19 patients admitted to a designated hospital in Beijing was analyzed to study the factors affecting the duration of viral shedding.
Results: The median duration of viral shedding was 11 days (IQR, 8-14.3 days) as measured from illness onset. Univariate regression analysis showed that disease severity, corticosteroid therapy, fever (temperature>38.5℃), and time from onset to hospitalization were associated with prolonged duration of viral shedding (p<0.05). Multivariate regression analysis showed that fever (temperature>38.5℃) (OR 5.1, 95%CI: 1.5-18.1), corticosteroid therapy (OR 6.3, 95%CI: 1.5-27.8), and time from onset to hospitalization (OR 1.8, 95%CI: 1.19-2.7) were associated with increased odds of prolonged duration of viral shedding.
Conclusions: Corticosteroid treatment, fever (temperature>38.5℃), and longer time from onset to hospitalization were associated with prolonged viral shedding in COVID-19 patients. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Coronavirus; duration of viral shedding.