tetano
Editor, Senior Moderator
J Med Virol. 2020 Apr 1. doi: 10.1002/jmv.25810. [Epub ahead of print]
Differences between COVID-19 and suspected then confirmed SARS-CoV-2-negative pneumonia: a retrospective study from a single center.
Chen X[SUP]1[/SUP], Yang Y[SUP]2[/SUP], Huang M[SUP]3[/SUP], Liu L[SUP]1[/SUP], Zhang X[SUP]4[/SUP], Xu J[SUP]1[/SUP], Geng S[SUP]1[/SUP], Han B[SUP]5[/SUP], Xiao J[SUP]6[/SUP], Wan Y[SUP]3[/SUP].
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Abstract
Coronavirus disease 2019 (COVID-19) broke out in Wuhan, Hubei, China in December 2019. Tens thousands of people have been infected with the disease. Our aim was to distinguish severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients from SARS-CoV-2-negative patients. We retrospectively compared the data of COVID-19 patients with those of suspected and confirmed SARS-CoV-2-negative patients (control patients). There were 78 COVID-19 patients and 26 control patients, whose median ages were significantly different (P=0.001). The percentage of COVID-19 patients admitting exposure to Wuhan was obviously higher than that of control patients (X[SUP]2[/SUP] =29.130, P<0.001). Fever and cough appeared more frequently in COVID-19 patients than in the control patients. The routine blood work-up parameters of COVID-19 patients did not change much and their mean counts were in normal range. There were 38.5% of control patients had higher procalcitonin (PCT) levels than 0.5ng/ml, which was significantly higher than that percentage of COVID-19 patients (X[SUP]2[/SUP] =22.636, P <0.05), and COVID-19 patients were also more likely to have decreased or normal urea and creatinine levels than control patients (X[SUP]2[/SUP] =24.930, 8.480, P <0.05).Younger age, exposure to Wuhan, fever, cough, and slight changes in routine blood work-up parameters, urea and creatinine were important features discriminating COVID-19 from control patients. Slightly increased, but far less than 0.5ng/ml, PCT levels also differentiated COVID-19 patients from control patients This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Coronavirus disease 2019 (COVID-19); laboratory test; procalcitonin; suspected then confirmed SARS-CoV-2-negative pneumonia; symptoms
PMID:32237148DOI:10.1002/jmv.25810
Differences between COVID-19 and suspected then confirmed SARS-CoV-2-negative pneumonia: a retrospective study from a single center.
Chen X[SUP]1[/SUP], Yang Y[SUP]2[/SUP], Huang M[SUP]3[/SUP], Liu L[SUP]1[/SUP], Zhang X[SUP]4[/SUP], Xu J[SUP]1[/SUP], Geng S[SUP]1[/SUP], Han B[SUP]5[/SUP], Xiao J[SUP]6[/SUP], Wan Y[SUP]3[/SUP].
Author information
Abstract
Coronavirus disease 2019 (COVID-19) broke out in Wuhan, Hubei, China in December 2019. Tens thousands of people have been infected with the disease. Our aim was to distinguish severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients from SARS-CoV-2-negative patients. We retrospectively compared the data of COVID-19 patients with those of suspected and confirmed SARS-CoV-2-negative patients (control patients). There were 78 COVID-19 patients and 26 control patients, whose median ages were significantly different (P=0.001). The percentage of COVID-19 patients admitting exposure to Wuhan was obviously higher than that of control patients (X[SUP]2[/SUP] =29.130, P<0.001). Fever and cough appeared more frequently in COVID-19 patients than in the control patients. The routine blood work-up parameters of COVID-19 patients did not change much and their mean counts were in normal range. There were 38.5% of control patients had higher procalcitonin (PCT) levels than 0.5ng/ml, which was significantly higher than that percentage of COVID-19 patients (X[SUP]2[/SUP] =22.636, P <0.05), and COVID-19 patients were also more likely to have decreased or normal urea and creatinine levels than control patients (X[SUP]2[/SUP] =24.930, 8.480, P <0.05).Younger age, exposure to Wuhan, fever, cough, and slight changes in routine blood work-up parameters, urea and creatinine were important features discriminating COVID-19 from control patients. Slightly increased, but far less than 0.5ng/ml, PCT levels also differentiated COVID-19 patients from control patients This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Coronavirus disease 2019 (COVID-19); laboratory test; procalcitonin; suspected then confirmed SARS-CoV-2-negative pneumonia; symptoms
PMID:32237148DOI:10.1002/jmv.25810