J Med Virol . A third booster dose may be necessary to mitigate neutralizing antibody fading after inoculation with two doses of an inactivated SARS

[tetano]

J Med Virol


. 2021 Sep 13.
doi: 10.1002/jmv.27334. Online ahead of print.
A third booster dose may be necessary to mitigate neutralizing antibody fading after inoculation with two doses of an inactivated SARS-CoV-2 vaccine


Lei Yue[SUP] 1 [/SUP], Tianhong Xie[SUP] 1 [/SUP], Ting Yang[SUP] 1 [/SUP], Jian Zhou[SUP] 1 [/SUP], Hongbo Chen[SUP] 1 [/SUP], Hailian Zhu[SUP] 1 [/SUP], Hua Li[SUP] 1 [/SUP], Hong Xiang[SUP] 1 [/SUP], Jie Wang[SUP] 1 [/SUP], Huijuan Yang[SUP] 1 [/SUP], Hong Zhao[SUP] 1 [/SUP], Xingchen Wei[SUP] 1 [/SUP], Yuhao Zhang[SUP] 1 [/SUP], Zhongping Xie[SUP] 1 [/SUP]



Affiliations

• PMID: 34516026
• DOI: 10.1002/jmv.27334

Abstract

Neutralizing antibodies in volunteers who received two doses of an inactivated SARS-CoV-2 vaccine deceased over several months. A three-dose procedure study suggested that the boost conferred by a third dose rescued the waning of neutralizing antibodies after the two doses of the inactivated vaccine. Importantly, a booster dose can also elicit a more robust neutralizing antibody response than the two-dose procedure. This article is protected by copyright. All rights reserved.

Keywords: Disease control; Humoral immunity; Immune responses; SARS coronavirus; Vaccines/Vaccine strains; Virus classification.