tetano
Editor, Senior Moderator
J Med Case Rep
. 2022 Aug 23;16(1):329.
doi: 10.1186/s13256-022-03539-9.
Encephalomyelitis associated with coronavirus disease 2019: a case report
Riwanti Estiasari[SUP] 1 2 [/SUP], Kartika Maharani[SUP] 3 4 [/SUP], Fitri Octaviana[SUP] 3 4 [/SUP], Anyelir Nielya Mutiara Putri[SUP] 3 [/SUP], Syifa Laila Ramadhan[SUP] 3 [/SUP], Anna Rozaliani[SUP] 5 4 [/SUP], Darma Imran[SUP] 3 4 [/SUP]
Affiliations
Abstract
Background: Despite a considerable number of articles regarding neurological manifestations associated with severe acute respiratory syndrome coronavirus 2 infection, reports on transverse myelitis and encephalitis are scarce.
Case presentation: We report a 35-year-old Asian Arab female presenting with longitudinally extensive transverse myelitis within 3 weeks after being diagnosed with mild coronavirus disease 2019 infection. Administration of high-dose methylprednisolone led to significant clinical improvement. However, 2 days after discharge, the patient was readmitted with encephalitis manifestations, consisting of fever and loss of consciousness, along with deterioration in myelitis symptoms. Severe acute respiratory syndrome coronavirus 2 antibody was detected in cerebrospinal fluid, but DNA of severe acute respiratory syndrome coronavirus 2 was not found. Clinical recovery was achieved after the administration of intravenous immunoglobulin.
Conclusion: Longitudinally extensive transverse myelitis can be a neurological manifestation of coronavirus disease 2019 and can be followed by encephalomyelitis episodes. High-dose steroids and intravenous immunoglobulin as an immunomodulator are possible effective treatment options.
Keywords: COVID-19; Case report; Encephalomyelitis; Longitudinally extensive transverse myelitis.
. 2022 Aug 23;16(1):329.
doi: 10.1186/s13256-022-03539-9.
Encephalomyelitis associated with coronavirus disease 2019: a case report
Riwanti Estiasari[SUP] 1 2 [/SUP], Kartika Maharani[SUP] 3 4 [/SUP], Fitri Octaviana[SUP] 3 4 [/SUP], Anyelir Nielya Mutiara Putri[SUP] 3 [/SUP], Syifa Laila Ramadhan[SUP] 3 [/SUP], Anna Rozaliani[SUP] 5 4 [/SUP], Darma Imran[SUP] 3 4 [/SUP]
Affiliations
- PMID: 35999589
- DOI: 10.1186/s13256-022-03539-9
Abstract
Background: Despite a considerable number of articles regarding neurological manifestations associated with severe acute respiratory syndrome coronavirus 2 infection, reports on transverse myelitis and encephalitis are scarce.
Case presentation: We report a 35-year-old Asian Arab female presenting with longitudinally extensive transverse myelitis within 3 weeks after being diagnosed with mild coronavirus disease 2019 infection. Administration of high-dose methylprednisolone led to significant clinical improvement. However, 2 days after discharge, the patient was readmitted with encephalitis manifestations, consisting of fever and loss of consciousness, along with deterioration in myelitis symptoms. Severe acute respiratory syndrome coronavirus 2 antibody was detected in cerebrospinal fluid, but DNA of severe acute respiratory syndrome coronavirus 2 was not found. Clinical recovery was achieved after the administration of intravenous immunoglobulin.
Conclusion: Longitudinally extensive transverse myelitis can be a neurological manifestation of coronavirus disease 2019 and can be followed by encephalomyelitis episodes. High-dose steroids and intravenous immunoglobulin as an immunomodulator are possible effective treatment options.
Keywords: COVID-19; Case report; Encephalomyelitis; Longitudinally extensive transverse myelitis.