tetano
Editor, Senior Moderator
J Korean Med Sci
. 2022 Sep 5;37(35):e267.
doi: 10.3346/jkms.2022.37.e267.
Relative Effectiveness of COVID-19 Vaccination in Healthcare Workers: 3-Dose Versus 2-Dose Vaccination
Sung Ran Kim[SUP] 1 [/SUP], Hyeon Jeong Kang[SUP] 1 [/SUP], Hye Rin Jeong[SUP] 1 [/SUP], Su Yeon Jang[SUP] 1 [/SUP], Jae Eun Lee[SUP] 1 [/SUP], Da Eun Kim[SUP] 1 [/SUP], Hae Ry Lee[SUP] 1 [/SUP], Min Hee Cho[SUP] 1 [/SUP], Ji Yun Noh[SUP] 1 2 3 [/SUP], Hee Jin Cheong[SUP] 1 2 3 [/SUP], Woo Joo Kim[SUP] 1 2 3 [/SUP], Joon Young Song[SUP] 1 2 4 [/SUP]
Affiliations
Abstract
The omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to have high infectivity and is more likely to evade vaccine immunity. However, booster vaccination is expected to strengthen cross-reactive immunity, thereby increasing the vaccine effectiveness (VE). This study aimed to evaluate the relative VE of the 3-dose (booster) vaccination compared with the 2-dose primary series vaccination in healthcare workers during omicron variant-dominant periods. During the omicron-dominant period from February 1, 2022 to February 28, 2022, a 1:1 matched case-control study was conducted. Healthcare workers with positive SARS-CoV-2 test results were classified as positive cases, whereas those with negative results served as controls. Compared with the 2-dose primary series vaccination, booster vaccination with mRNA vaccine showed moderate VE (53.1%). However, in multivariate analysis including the time elapsed after vaccination, the significant VE disappeared, reflecting the impact of recent vaccination rather than the third dose itself.
Keywords: COVID-19; Healthcare Worker; SARS-CoV-2; Vaccine Effectiveness.
. 2022 Sep 5;37(35):e267.
doi: 10.3346/jkms.2022.37.e267.
Relative Effectiveness of COVID-19 Vaccination in Healthcare Workers: 3-Dose Versus 2-Dose Vaccination
Sung Ran Kim[SUP] 1 [/SUP], Hyeon Jeong Kang[SUP] 1 [/SUP], Hye Rin Jeong[SUP] 1 [/SUP], Su Yeon Jang[SUP] 1 [/SUP], Jae Eun Lee[SUP] 1 [/SUP], Da Eun Kim[SUP] 1 [/SUP], Hae Ry Lee[SUP] 1 [/SUP], Min Hee Cho[SUP] 1 [/SUP], Ji Yun Noh[SUP] 1 2 3 [/SUP], Hee Jin Cheong[SUP] 1 2 3 [/SUP], Woo Joo Kim[SUP] 1 2 3 [/SUP], Joon Young Song[SUP] 1 2 4 [/SUP]
Affiliations
- PMID: 36065651
- DOI: 10.3346/jkms.2022.37.e267
Abstract
The omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to have high infectivity and is more likely to evade vaccine immunity. However, booster vaccination is expected to strengthen cross-reactive immunity, thereby increasing the vaccine effectiveness (VE). This study aimed to evaluate the relative VE of the 3-dose (booster) vaccination compared with the 2-dose primary series vaccination in healthcare workers during omicron variant-dominant periods. During the omicron-dominant period from February 1, 2022 to February 28, 2022, a 1:1 matched case-control study was conducted. Healthcare workers with positive SARS-CoV-2 test results were classified as positive cases, whereas those with negative results served as controls. Compared with the 2-dose primary series vaccination, booster vaccination with mRNA vaccine showed moderate VE (53.1%). However, in multivariate analysis including the time elapsed after vaccination, the significant VE disappeared, reflecting the impact of recent vaccination rather than the third dose itself.
Keywords: COVID-19; Healthcare Worker; SARS-CoV-2; Vaccine Effectiveness.