tetano
Editor, Senior Moderator
J Korean Med Sci
. 2021 Nov 8;36(43):e294.
doi: 10.3346/jkms.2021.36.e294.
Prevalence of SARS-CoV-2 Antibody in 2,935 Healthcare Workers at 6 Major Hospitals, Daegu, Korea
Yu Kyung Kim[SUP] #[/SUP][SUP] 1 [/SUP], Dohsik Minn[SUP] #[/SUP][SUP] 2 [/SUP], Do Young Song[SUP] 3 [/SUP], Chae Hoon Lee[SUP] 4 [/SUP], Nam Hee Ryoo[SUP] 5 [/SUP], Chang-Ho Jeon[SUP] 6 [/SUP], Kyung Eun Song[SUP] 1 7 [/SUP], Jang Soo Suh[SUP] 1 [/SUP], Soon Hee Chang[SUP] 8 [/SUP]
Affiliations
Abstract
Background: In Korea, the first community outbreak of coronavirus disease 2019 (COVID-19) occurred in Daegu on February 18, 2020. This study was performed to investigate the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies in healthcare workers (HCWs) at 6 major hospitals in Daegu.
Methods: Blood specimens of 2,935 HCWs at 6 major hospitals in Daegu from January 2021 to February 2021 were collected. Every specimen was tested for antibody against SARS-CoV-2 using both Elecsys Anti-SARS-CoV-2 electrochemiluminescence immunoassay (Roche Diagnostics, Rotkreuz, Switzerland) and R-FIND COVID-19 IgG/M/A enzyme-linked immunosorbent assay kit (SG medical Inc., Seoul, Korea) as screening tests. If 1 or more of these screening test results was positive, 2 additional antibody tests were performed using Abbott Anti-SARS-CoV-2 IgG assay (Abbott, Abbott Park, IL, USA) and cPass SARS-CoV-2 Neutralization Antibody Detection Kit (GenScript USA Inc., Piscataway, NJ, USA). If 2 or more of the total 4 test results were positive, it was determined as positive for the antibody against SARS-CoV-2.
Results: According to the criteria of SARS-CoV-2 antibody positivity determination, 12 subjects were determined as positive. The overall positive rate of the SARS-CoV-2 antibody was 0.41% (12/2,935). Of the 12 subjects determined as positive, 7 were diagnosed with COVID-19, and the remaining 5 were nondiagnosed cases of COVID-19.
Conclusion: In early 2021, the overall seroprevalence of SARS-CoV-2 antibody among HCW located in Daegu was 0.41%, and 0.17% excluding COVID-19 confirmed subjects. These results were not particularly high compared with the general public and were much lower than HCWs in other countries.
Keywords: COVID-19; Healthcare Worker; Neutralizing Antibody; SARS-CoV-2 Antibody.
. 2021 Nov 8;36(43):e294.
doi: 10.3346/jkms.2021.36.e294.
Prevalence of SARS-CoV-2 Antibody in 2,935 Healthcare Workers at 6 Major Hospitals, Daegu, Korea
Yu Kyung Kim[SUP] #[/SUP][SUP] 1 [/SUP], Dohsik Minn[SUP] #[/SUP][SUP] 2 [/SUP], Do Young Song[SUP] 3 [/SUP], Chae Hoon Lee[SUP] 4 [/SUP], Nam Hee Ryoo[SUP] 5 [/SUP], Chang-Ho Jeon[SUP] 6 [/SUP], Kyung Eun Song[SUP] 1 7 [/SUP], Jang Soo Suh[SUP] 1 [/SUP], Soon Hee Chang[SUP] 8 [/SUP]
Affiliations
- PMID: 34751011
- DOI: 10.3346/jkms.2021.36.e294
Abstract
Background: In Korea, the first community outbreak of coronavirus disease 2019 (COVID-19) occurred in Daegu on February 18, 2020. This study was performed to investigate the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies in healthcare workers (HCWs) at 6 major hospitals in Daegu.
Methods: Blood specimens of 2,935 HCWs at 6 major hospitals in Daegu from January 2021 to February 2021 were collected. Every specimen was tested for antibody against SARS-CoV-2 using both Elecsys Anti-SARS-CoV-2 electrochemiluminescence immunoassay (Roche Diagnostics, Rotkreuz, Switzerland) and R-FIND COVID-19 IgG/M/A enzyme-linked immunosorbent assay kit (SG medical Inc., Seoul, Korea) as screening tests. If 1 or more of these screening test results was positive, 2 additional antibody tests were performed using Abbott Anti-SARS-CoV-2 IgG assay (Abbott, Abbott Park, IL, USA) and cPass SARS-CoV-2 Neutralization Antibody Detection Kit (GenScript USA Inc., Piscataway, NJ, USA). If 2 or more of the total 4 test results were positive, it was determined as positive for the antibody against SARS-CoV-2.
Results: According to the criteria of SARS-CoV-2 antibody positivity determination, 12 subjects were determined as positive. The overall positive rate of the SARS-CoV-2 antibody was 0.41% (12/2,935). Of the 12 subjects determined as positive, 7 were diagnosed with COVID-19, and the remaining 5 were nondiagnosed cases of COVID-19.
Conclusion: In early 2021, the overall seroprevalence of SARS-CoV-2 antibody among HCW located in Daegu was 0.41%, and 0.17% excluding COVID-19 confirmed subjects. These results were not particularly high compared with the general public and were much lower than HCWs in other countries.
Keywords: COVID-19; Healthcare Worker; Neutralizing Antibody; SARS-CoV-2 Antibody.