tetano
Editor, Senior Moderator
J Korean Med Sci
. 2022 Oct 24;37(41):e297.
doi: 10.3346/jkms.2022.37.e297.
Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea
Youseung Chung[SUP] 1 [/SUP], Eun Jin Kim[SUP] 2 [/SUP], Hee-Sung Kim[SUP] 3 [/SUP], Kyung-Hwa Park[SUP] 4 [/SUP], Ji Hyeon Baek[SUP] 5 [/SUP], Jungok Kim[SUP] 6 7 [/SUP], Ji Yeon Lee[SUP] 8 [/SUP], Chang-Seop Lee[SUP] 9 [/SUP], Seungjin Lim[SUP] 10 [/SUP], Shin-Woo Kim[SUP] 11 [/SUP], Eu Suk Kim[SUP] 12 [/SUP], Hye Jin Shi[SUP] 13 [/SUP], Shin Hee Hong[SUP] 13 [/SUP], Jae-Bum Jun[SUP] 14 [/SUP], Kyung-Wook Hong[SUP] 15 [/SUP], Jae-Phil Choi[SUP] 16 [/SUP], Jinyeong Kim[SUP] 17 [/SUP], Kyung Sook Yang[SUP] 18 [/SUP], Young Kyung Yoon[SUP] 19 [/SUP]
Affiliations
Abstract
Background: This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19.
Methods: This multicenter observational study included consecutive pregnant women admitted because of COVID-19 confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) test at 15 hospitals in the Republic of Korea between January 2020 and December 2021.
Results: A total of 257 women with COVID-19 and 62 newborns were included in this study. Most of the patients developed this disease during the third trimester. Nine patients (7.4%) developed pregnancy-related complications. All pregnant women received inpatient treatment, of whom 9 (3.5%) required intensive care, but none of them died. The gestational age at COVID-19 diagnosis (odds ratio [OR], 1.096, 95% confidence interval [CI], 1.04-1.15) and parity (OR, 1.703, 95% CI, 1.13-2.57) were identified as significant risk factors of severe diseases. Among women who delivered, 78.5% underwent cesarean section. Preterm birth (38.5%), premature rupture of membranes (7.7%), and miscarriage (4.6%) occurred, but there was no stillbirth or neonatal death. The RT-PCR test of newborns' amniotic fluid and umbilical cord blood samples was negative for severe acute respiratory syndrome coronavirus 2.
Conclusion: At the time of COVID-19 diagnosis, gestational age and parity of pregnant women were the risk factors of disease severity. Vertical transmission of COVID-19 was not observed, and maternal severity did not significantly affect the neonatal prognosis.
Keywords: Coronavirus Disease 2019; Neonate; Pregnancy; Severe Acute Respiratory Syndrome Coronavirus 2.
. 2022 Oct 24;37(41):e297.
doi: 10.3346/jkms.2022.37.e297.
Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea
Youseung Chung[SUP] 1 [/SUP], Eun Jin Kim[SUP] 2 [/SUP], Hee-Sung Kim[SUP] 3 [/SUP], Kyung-Hwa Park[SUP] 4 [/SUP], Ji Hyeon Baek[SUP] 5 [/SUP], Jungok Kim[SUP] 6 7 [/SUP], Ji Yeon Lee[SUP] 8 [/SUP], Chang-Seop Lee[SUP] 9 [/SUP], Seungjin Lim[SUP] 10 [/SUP], Shin-Woo Kim[SUP] 11 [/SUP], Eu Suk Kim[SUP] 12 [/SUP], Hye Jin Shi[SUP] 13 [/SUP], Shin Hee Hong[SUP] 13 [/SUP], Jae-Bum Jun[SUP] 14 [/SUP], Kyung-Wook Hong[SUP] 15 [/SUP], Jae-Phil Choi[SUP] 16 [/SUP], Jinyeong Kim[SUP] 17 [/SUP], Kyung Sook Yang[SUP] 18 [/SUP], Young Kyung Yoon[SUP] 19 [/SUP]
Affiliations
- PMID: 36281486
- DOI: 10.3346/jkms.2022.37.e297
Abstract
Background: This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19.
Methods: This multicenter observational study included consecutive pregnant women admitted because of COVID-19 confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) test at 15 hospitals in the Republic of Korea between January 2020 and December 2021.
Results: A total of 257 women with COVID-19 and 62 newborns were included in this study. Most of the patients developed this disease during the third trimester. Nine patients (7.4%) developed pregnancy-related complications. All pregnant women received inpatient treatment, of whom 9 (3.5%) required intensive care, but none of them died. The gestational age at COVID-19 diagnosis (odds ratio [OR], 1.096, 95% confidence interval [CI], 1.04-1.15) and parity (OR, 1.703, 95% CI, 1.13-2.57) were identified as significant risk factors of severe diseases. Among women who delivered, 78.5% underwent cesarean section. Preterm birth (38.5%), premature rupture of membranes (7.7%), and miscarriage (4.6%) occurred, but there was no stillbirth or neonatal death. The RT-PCR test of newborns' amniotic fluid and umbilical cord blood samples was negative for severe acute respiratory syndrome coronavirus 2.
Conclusion: At the time of COVID-19 diagnosis, gestational age and parity of pregnant women were the risk factors of disease severity. Vertical transmission of COVID-19 was not observed, and maternal severity did not significantly affect the neonatal prognosis.
Keywords: Coronavirus Disease 2019; Neonate; Pregnancy; Severe Acute Respiratory Syndrome Coronavirus 2.